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alloxan - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alloxan
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Accession:CHEBI:76451 term browser browse the term
Definition:A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Synonyms:exact_synonym: pyrimidine-2,4,5,6(1H,3H)-tetrone
 related_synonym: 2,4,5,6(1H,3H)-Pyrimidinetetrone;   2,4,5,6-Tetraoxohexahydropyrimidine;   2,4,5,6-pyrimidinetetrone;   5,6-dioxouracil;   5-oxobarbituric acid;   Alloxane;   Formula=C4H2N2O4;   InChI=1S/C4H2N2O4/c7-1-2(8)5-4(10)6-3(1)9/h(H2,5,6,8,9,10);   InChIKey=HIMXGTXNXJYFGB-UHFFFAOYSA-N;   Mesoxalylcarbamide;   Mesoxalylurea;   NSC 7169;   Pyrimidinetetrone;   SMILES=O=C1NC(=O)C(=O)C(=O)N1
 xref: CAS:50-71-5;   HMDB:HMDB0002818
 xref_mesh: MESH:D000496
 xref: MetaCyc:CPD-3684;   PDBeChem:LXN;   PMID:21344938;   PMID:23408741;   PMID:23473942;   PMID:23658878;   PMID:23667864;   PMID:23762986;   PMID:24129090;   PMID:24374440;   Reaxys:132451;   Wikipedia:Alloxan

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alloxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity
multiple interactions 		EXP Alloxan results in increased activity of ACHE protein
higenamine inhibits the reaction [Alloxan results in increased activity of ACHE protein]; nuciferine inhibits the reaction [Alloxan results in increased activity of ACHE protein] 		CTD PMID:36297317 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases activity 		EXP Chromium inhibits the reaction [Alloxan results in increased activity of ACOX1 protein]; chromium tripicolinate inhibits the reaction [Alloxan results in increased activity of ACOX1 protein] CTD PMID:19693677 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Actb actin, beta decreases expression ISO Alloxan results in decreased expression of ACTB mRNA CTD PMID:12137914 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP [Alloxan co-treated with Niacinamide] affects the expression of ADIPOQ protein CTD PMID:26429928 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions 		ISO
EXP 		Alloxan results in decreased phosphorylation of AKT1 protein
Phycocyanin inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein] 		CTD PMID:26827782 PMID:33359794 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression
multiple interactions
increases expression 		EXP Alloxan results in decreased expression of APAF1 protein
Taurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein] 		CTD PMID:21982801 PMID:23092809 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions
decreases expression 		EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of ATP2A1 protein] CTD PMID:28483572 NCBI chr 1:190,457,198...190,475,410
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression EXP Alloxan results in decreased expression of ATP2A2 protein CTD PMID:28483572 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions 		EXP Alloxan results in increased expression of BAD protein
Taurine inhibits the reaction [Alloxan results in increased expression of BAD protein] 		CTD PMID:22138235 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		EXP Taurine inhibits the reaction [Alloxan results in increased expression of BAX protein] CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		EXP Alloxan results in decreased expression of BCL2 protein
Taurine inhibits the reaction [Alloxan results in decreased expression of BCL2 protein] 		CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions 		EXP Alloxan results in decreased expression of BCL2L1 protein
Taurine inhibits the reaction [Alloxan results in decreased expression of BCL2L1 protein] 		CTD PMID:22138235 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression 		EXP D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP3 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP3 protein modified form] CTD PMID:21982801 PMID:22138235 PMID:23092809 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions 		EXP Alloxan results in increased activity of CASP9 protein
Alloxan results in increased expression of CASP9 protein; Alloxan results in increased expression of CASP9 protein modified form
D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased activity of CASP9 protein]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP9 protein modified form]; Taurine inhibits the reaction [Alloxan results in increased expression of CASP9 protein] 		CTD PMID:21982801 PMID:22138235 PMID:23092809 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity 		EXP
ISO 		3,4-dihydroxyphenylethanol inhibits the reaction [Alloxan results in decreased expression of CAT protein]; Chromium inhibits the reaction [Alloxan results in decreased activity of CAT protein]; chromium tripicolinate inhibits the reaction [Alloxan results in decreased activity of CAT protein]; D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of CAT protein]; higenamine inhibits the reaction [Alloxan results in decreased activity of CAT protein]; nuciferine inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Alloxan results in decreased expression of CAT protein]
Plant Oils inhibits the reaction [Alloxan results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Alloxan results in decreased activity of CAT protein] 		CTD PMID:10871429 PMID:19393637 PMID:19693677 PMID:21982801 PMID:24946265 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [Cathelicidins results in increased expression of CCL2 protein]] CTD PMID:18949387 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions
decreases expression 		EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of COX4I1 protein] CTD PMID:28483572 NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization 		EXP Taurine inhibits the reaction [Alloxan affects the localization of CYCS protein] CTD PMID:22138235 PMID:23092809 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Alloxan results in increased expression of DDIT3 mRNA; Alloxan results in increased expression of DDIT3 protein CTD PMID:30076216 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Foxp3 forkhead box P3 decreases expression
multiple interactions 		ISO Alloxan results in decreased expression of FOXP3 protein
platycodin D inhibits the reaction [Alloxan results in decreased expression of FOXP3 protein] 		CTD PMID:25887267 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases activity
multiple interactions 		EXP Alloxan results in increased activity of G6PC1 protein
Sodium Selenite inhibits the reaction [Alloxan results in increased activity of G6PC1 protein] 		CTD PMID:25779343 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gck glucokinase multiple interactions
decreases expression 		ISO
EXP 		Glucose inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCK protein]
Alloxan results in decreased expression of GCK mRNA; Alloxan results in decreased expression of GCK protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCK mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCK protein] 		CTD PMID:12137914 PMID:26827782 PMID:33359794 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gckr glucokinase regulator decreases expression
multiple interactions 		ISO Alloxan results in decreased expression of GCKR protein
Phycocyanin inhibits the reaction [Alloxan results in decreased expression of GCKR protein] 		CTD PMID:26827782 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
multiple interactions 		EXP Alloxan results in decreased expression of GCLC mRNA; Alloxan results in decreased expression of GCLC protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]] 		CTD PMID:33359794 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gip gastric inhibitory polypeptide increases secretion EXP Alloxan results in increased secretion of GIP protein CTD PMID:6753106 NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [Alloxan results in increased susceptibility to titanium dioxide] which results in increased activity of GPT protein CTD PMID:23873220 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity 		EXP D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased activity of GSR protein] CTD PMID:21982801 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions 		EXP Alloxan results in decreased expression of HMOX1 mRNA; Alloxan results in decreased expression of HMOX1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]] 		CTD PMID:33359794 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Alloxan results in increased expression of HSPA5 mRNA CTD PMID:30076216 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Alloxan inhibits the reaction [Glucosamine inhibits the reaction [Cathelicidins results in increased expression of ICAM1 protein]] CTD PMID:18949387 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Alloxan results in decreased expression of and results in decreased secretion of IL10 protein; platycodin D inhibits the reaction [Alloxan results in decreased expression of and results in decreased secretion of IL10 protein] CTD PMID:25887267 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B decreases expression ISO Alloxan results in decreased expression of IL12B protein CTD PMID:16249388 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Alloxan results in increased expression of and results in increased secretion of IL17A protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL17A protein] CTD PMID:25887267 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Alloxan results in increased expression of and results in increased secretion of IL1B protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL1B protein] CTD PMID:25887267 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		EXP
ISO 		Taurine inhibits the reaction [Alloxan results in increased expression of IL6 protein]
Alloxan results in increased expression of and results in increased secretion of IL6 protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of IL6 protein] 		CTD PMID:22138235 PMID:25887267 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions
decreases expression
decreases secretion 		ISO
EXP 		Plant Oils inhibits the reaction [Alloxan results in decreased expression of INS1 protein]
[Alloxan co-treated with Homocysteine] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [Sertraline binds to 2-Hydroxypropyl-beta-cyclodextrin] inhibits the reaction [Alloxan results in decreased expression of INS1 protein]; Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]; D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in decreased expression of INS1 protein]; ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; Plant Preparations inhibits the reaction [Alloxan results in decreased secretion of INS1 protein]; Sertraline inhibits the reaction [Alloxan results in decreased expression of INS1 protein] 		CTD PMID:19393637 PMID:21050842 PMID:21982801 PMID:26593071 PMID:27317948 More... NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Insr insulin receptor decreases phosphorylation
multiple interactions 		EXP Alloxan results in decreased phosphorylation of INSR protein
Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of INSR protein] 		CTD PMID:22138235 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation
multiple interactions
affects phosphorylation 		EXP
ISO 		Alloxan results in decreased phosphorylation of IRS1 protein
Taurine inhibits the reaction [Alloxan results in decreased phosphorylation of IRS1 protein]
Alloxan affects the phosphorylation of IRS1 protein
Phycocyanin inhibits the reaction [Alloxan affects the phosphorylation of IRS1 protein] 		CTD PMID:22138235 PMID:26827782 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		EXP Alloxan results in increased phosphorylation of MAPK1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in increased phosphorylation of MAPK1 protein] 		CTD PMID:33359794 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		EXP ginsenoside Rh4 inhibits the reaction [Alloxan results in increased phosphorylation of MAPK3 protein] CTD PMID:33359794 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions 		EXP Alloxan results in decreased expression of MFN2 protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of MFN2 protein] 		CTD PMID:28483572 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions 		EXP Alloxan results in increased activity of MPO protein
Taurine inhibits the reaction [Alloxan results in increased activity of MPO protein] 		CTD PMID:22138235 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions
decreases expression 		EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of NDUFA9 protein] CTD PMID:28483572 NCBI chr 4:161,345,398...161,374,188
Ensembl chr 4:159,659,242...159,688,018 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
affects localization
multiple interactions 		EXP Alloxan results in decreased expression of NFE2L2 mRNA
Alloxan affects the localization of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan affects the localization of NFE2L2 protein]]; ginsenoside Rh4 inhibits the reaction [Alloxan affects the localization of NFE2L2 protein]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of GCLC protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]] 		CTD PMID:33359794 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression ISO Alloxan results in decreased expression of NOS1 mRNA CTD PMID:30076216 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Alloxan results in increased expression of NOS2 mRNA CTD PMID:30076216 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions 		EXP Alloxan results in decreased expression of NQO1 mRNA; Alloxan results in decreased expression of NQO1 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of NQO1 protein]] 		CTD PMID:33359794 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP Alloxan affects the reaction [imisopasem manganese results in increased expression of NRF1 protein] CTD PMID:28483572 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation
multiple interactions 		EXP Alloxan results in increased degradation of PARP1 protein
D-Glucaric acid, 1,4-lactone inhibits the reaction [Alloxan results in increased degradation of PARP1 protein] 		CTD PMID:21982801 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions
decreases expression 		EXP ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of PDX1 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of PDX1 protein]
Alloxan results in decreased expression of PDX1 mRNA; Alloxan results in decreased expression of PDX1 protein 		CTD PMID:33359794 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression 		EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of PPARGC1A protein] CTD PMID:28483572 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression 		ISO
EXP 		Alloxan inhibits the reaction [Glucosamine inhibits the reaction [TNF results in increased phosphorylation of RELA protein]]
Alloxan results in increased expression of RELA protein
Taurine inhibits the reaction [Alloxan results in increased expression of RELA protein] 		CTD PMID:19020780 PMID:22138235 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions 		ISO Alloxan results in increased expression of RORC protein
platycodin D inhibits the reaction [Alloxan results in increased expression of RORC protein] 		CTD PMID:25887267 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions
decreases expression 		EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SDHA protein] CTD PMID:28483572 NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression
multiple interactions 		ISO
EXP 		Alloxan results in decreased expression of SLC2A2 mRNA
Glucose inhibits the reaction [Alloxan results in decreased expression of SLC2A2 mRNA]
Alloxan results in decreased expression of SLC2A2 mRNA; Alloxan results in decreased expression of SLC2A2 protein
ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of SLC2A2 mRNA]; ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased expression of SLC2A2 protein] 		CTD PMID:12137914 PMID:33359794 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization
multiple interactions
decreases expression 		EXP
ISO 		Alloxan affects the localization of SLC2A4 protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein]; Taurine inhibits the reaction [Alloxan affects the localization of SLC2A4 protein]
Quercetin inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein] 		CTD PMID:22138235 PMID:24946265 PMID:28483572 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Sod1 superoxide dismutase 1 affects response to substance
multiple interactions
decreases activity 		ISO
EXP 		SOD1 protein affects the susceptibility to Alloxan
Sulfur Dioxide inhibits the reaction [Alloxan results in decreased activity of SOD1 protein] 		CTD PMID:10871429 PMID:18502742 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO
EXP 		Alloxan inhibits the reaction [Glucosamine inhibits the reaction [TNF results in increased phosphorylation of RELA protein]]
Taurine inhibits the reaction [Alloxan results in increased expression of TNF protein]
Alloxan results in increased expression of and results in increased secretion of TNF protein; platycodin D inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein]; Rosiglitazone inhibits the reaction [Alloxan results in increased expression of and results in increased secretion of TNF protein] 		CTD PMID:19020780 PMID:22138235 PMID:25887267 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases expression ISO Alloxan results in increased expression of TRPM7 mRNA; Alloxan results in increased expression of TRPM7 protein CTD PMID:30076216 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 increases expression
multiple interactions 		EXP Alloxan results in increased expression of UQCRC2 protein
imisopasem manganese promotes the reaction [Alloxan results in increased expression of UQCRC2 protein] 		CTD PMID:28483572 NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:175,167,894...175,199,453 		JBrowse link
G Xdh xanthine dehydrogenase increases activity
multiple interactions 		EXP Alloxan results in increased activity of XDH protein
Taurine inhibits the reaction [Alloxan results in increased activity of XDH protein] 		CTD PMID:22138235 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        xenobiotic 19523
          barbituric acid 70
            alloxan 61
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                organic heterocyclic compound 19383
                                  organic heteromonocyclic compound 18207
                                    diazines 13845
                                      pyrimidines 13733
                                        pyrimidone 10694
                                          barbiturates 4666
                                            barbituric acid 70
                                              alloxan 61
paths to the root