inorganic radical ion - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	inorganic radical ion	go back to main search page
Accession:	CHEBI:36878	browse the term
Synonyms:	related_synonym:	inorganic radical ions

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Genes (98)

superoxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

multiple interactions

ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides]

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

aconitase 1

multiple interactions
decreases activity

[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein
Superoxides results in decreased activity of ACO1 protein

NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769

G

aconitase 2

multiple interactions
decreases activity

[[[Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron] which co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Hydroxyl Radical; [Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron

NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273

G

adenosine deaminase

multiple interactions

ADA protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]

NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252

G

angiotensinogen

multiple interactions
increases abundance

1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; Propranolol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]
SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]
AGT protein modified form results in increased abundance of Superoxides; AGT protein results in increased abundance of Superoxides
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]

PMID:12606818 PMID:16531806 PMID:16864745 PMID:17272743 PMID:17391658 More...

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

angiotensin II receptor type 1

multiple interactions

[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]

NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008

G

aldo-keto reductase family 1 member C3

multiple interactions

[AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; [AKR1C3 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3,6-quinone] which results in increased chemical synthesis of Superoxides

PMID:19442656 PMID:21910479

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

aldo-keto reductase family 7 member A2

multiple interactions

[[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone] which results in increased chemical synthesis of Superoxides; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides

NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,301,991...19,312,144

G

albumin

increases chemical synthesis
multiple interactions

ALB protein modified form results in increased chemical synthesis of Superoxides
Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides]

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

aldehyde dehydrogenase 5 family member A1

multiple interactions

[ALDH5A1 gene mutant form results in increased susceptibility to 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] which results in increased abundance of Superoxides; [ALDH5A1 gene mutant form results in increased susceptibility to NCS 382] which results in increased abundance of Superoxides

NCBI chr 6:24,494,969...24,537,207
Ensembl chr 6:24,494,867...24,537,207

G

apolipoprotein E

increases chemical synthesis
increases abundance
multiple interactions

APOE gene mutant form results in increased chemical synthesis of Superoxides
APOE gene mutant form results in increased abundance of Superoxides
imisopasem manganese inhibits the reaction [APOE gene mutant form results in increased chemical synthesis of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [APOE gene mutant form results in increased abundance of Superoxides]

PMID:11397713 PMID:12871831

NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393

G

amyloid beta precursor protein

multiple interactions
increases chemical synthesis

3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; resveratrol inhibits the reaction [APP protein results in increased abundance of Superoxides]

PMID:16212921 PMID:22886847

NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128

G

androgen receptor

multiple interactions

Superoxides promotes the reaction [methylselenic acid results in decreased expression of AR protein]

NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619

G

ARF GTPase 6

multiple interactions

1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]; ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]

NCBI chr14:49,893,082...49,897,054
Ensembl chr14:49,893,079...49,897,054

G

arrestin beta 2

affects abundance

ARRB2 protein affects the abundance of Superoxides

NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499

G

antioxidant 1 copper chaperone

multiple interactions

ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]

NCBI chr 5:151,742,822...151,758,631
Ensembl chr 5:151,742,316...151,772,532

G

ATPase copper transporting alpha

increases abundance
multiple interactions

ATP7A mutant form results in increased abundance of Superoxides
[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; ATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; ATP7A protein inhibits the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]

PMID:18768397 PMID:23884884

NCBI chr X:77,910,693...78,050,395
Ensembl chr X:77,910,690...78,050,395

G

complement C5

multiple interactions
increases abundance

8-(4-sulfophenyl)theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]

NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195

G

catalase

multiple interactions

CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cystathionine beta-synthase

multiple interactions
affects abundance

SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides]

NCBI chr21:43,053,191...43,076,873
Ensembl chr21:43,053,191...43,076,943

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein]
Superoxides results in increased expression of CCL2 mRNA
1,3-dimethylthiourea inhibits the reaction [Superoxides results in increased expression of CCL2 mRNA]

PMID:8856246 PMID:19158351

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

CD38 molecule

multiple interactions
affects localization

tempol inhibits the reaction [Superoxides affects the localization of CD38 protein]

NCBI chr 4:15,778,328...15,853,232
Ensembl chr 4:15,778,275...15,853,232

G

C-reactive protein

multiple interactions

CRP protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]

NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589

G

cytochrome b-245 alpha chain

multiple interactions
increases abundance

CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides]
CYBA protein results in increased abundance of Superoxides

PMID:10720412 PMID:14871555 PMID:20523355

NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083

G

cytochrome b-245 beta chain

multiple interactions

CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein affects the reaction [Folic Acid deficiency results in increased chemical synthesis of Superoxides]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein promotes the reaction [[Doxorubicin co-treated with NADP] results in increased abundance of Superoxides]
IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides]

PMID:16354686 PMID:17275678 PMID:20116427 PMID:21647593

NCBI chr X:37,780,059...37,813,461
Ensembl chr X:37,780,018...37,813,461

G

cytochrome P450 family 1 subfamily A member 1

increases abundance

CYP1A1 protein results in increased abundance of Superoxides

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

dicarbonyl and L-xylulose reductase

increases chemical synthesis
multiple interactions

DCXR protein results in increased chemical synthesis of Superoxides
[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides]

NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709

G

DNA damage inducible transcript 3

increases abundance
increases expression
multiple interactions

DDIT3 protein results in increased abundance of Superoxides
Superoxides results in increased expression of DDIT3 mRNA; Superoxides results in increased expression of DDIT3 protein
[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein; [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

endothelin 1

multiple interactions
increases abundance

[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides; Catechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]; Polyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]
NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]

PMID:20977430 PMID:23940720

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

endothelin receptor type A

affects abundance

EDNRA protein affects the abundance of Superoxides

NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954

G

E1A binding protein p300

decreases abundance

EP300 protein results in decreased abundance of Superoxides

NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077

G

erythropoietin

multiple interactions

EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]

NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700

G

ERCC excision repair 6, chromatin remodeling factor

multiple interactions
decreases abundance
increases abundance

3-aminobenzamide inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; NU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]
ERCC6 protein results in decreased abundance of Superoxides

NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538

G

estrogen receptor 1

multiple interactions

[4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] which results in decreased abundance of Superoxides; [ESR1 protein results in increased susceptibility to Estradiol] which results in increased abundance of Superoxides; ESR1 protein affects the reaction [Estradiol results in decreased chemical synthesis of Superoxides]

PMID:18354059 PMID:23000059

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

fragile X messenger ribonucleoprotein 1

multiple interactions
increases abundance

Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Superoxides]

NCBI chr X:147,911,919...147,951,125
Ensembl chr X:147,911,919...147,951,125

G

fibronectin 1

multiple interactions

Superoxides affects the reaction [Glucose results in increased expression of FN1 mRNA]

NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA]

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]

NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374

G

growth arrest specific 5

increases expression

Superoxides results in increased expression of GAS5 mRNA; Superoxides results in increased expression of GAS5 protein

NCBI chr 1:173,863,901...173,869,045
Ensembl chr 1:173,851,424...173,868,940

G

GTP cyclohydrolase 1

affects abundance

GCH1 protein affects the abundance of Superoxides

NCBI chr14:54,842,017...54,902,826
Ensembl chr14:54,842,008...54,902,826

G

heme oxygenase 1

multiple interactions
decreases abundance
increases abundance

[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]
HMOX1 protein results in decreased abundance of Superoxides
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [cobaltous chloride results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Superoxides; [tin mesoporphyrin results in decreased activity of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]

PMID:15821039 PMID:16959961 PMID:18073186 PMID:18178725 PMID:18334666 More...

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

HRas proto-oncogene, GTPase

increases abundance
multiple interactions

HRAS protein mutant form results in increased abundance of Superoxides
[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein

NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321

G

heat shock protein family B (small) member 1

multiple interactions
decreases abundance

[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of HSPB1 protein
HSPB1 protein results in decreased abundance of Superoxides

PMID:14975446 PMID:19193722

NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,305,813

G

immediate early response 3

affects chemical synthesis

IER3 protein affects the chemical synthesis of Superoxides

NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548

G

insulin like growth factor 1

decreases abundance

IGF1 protein results in decreased abundance of Superoxides

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

interleukin 1 beta

multiple interactions
increases abundance

diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Superoxides]; IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides]

PMID:16354686 PMID:21211511

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 5

multiple interactions

1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]

NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838

G

INS-IGF2 readthrough

multiple interactions

[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]

NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209

G

integrin subunit alpha 3

multiple interactions

[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein

NCBI chr17:50,056,110...50,090,481
Ensembl chr17:50,055,968...50,090,481

G

integrin subunit beta 1

multiple interactions

[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Superoxides affects the reaction [Glucose results in increased phosphorylation of JUN protein]
Superoxides results in increased expression of JUN mRNA
SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]

PMID:9067545 PMID:16572112

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

lysine acetyltransferase 2A

decreases abundance

KAT2A protein results in decreased abundance of Superoxides

NCBI chr17:42,113,111...42,121,367
Ensembl chr17:42,113,111...42,121,367

G

lysine acetyltransferase 2B

decreases abundance

KAT2B protein results in decreased abundance of Superoxides

NCBI chr 3:20,040,446...20,154,404
Ensembl chr 3:20,040,446...20,154,404

G

kinase insert domain receptor

increases phosphorylation

Superoxides results in increased phosphorylation of KDR protein

NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595

G

leptin

multiple interactions
increases abundance

acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; BQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides]
[LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides

PMID:11342529 PMID:16380530

NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629

G

leptin receptor

multiple interactions
increases abundance

acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]; resveratrol inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]

NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559

G

lipoprotein(a)

multiple interactions

[[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein; [Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein

NCBI chr 6:160,531,482...160,664,275
Ensembl chr 6:160,531,482...160,664,275

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Superoxides results in increased phosphorylation of MAPK1 protein

PMID:16572112 PMID:19268487

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation

Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Superoxides results in increased phosphorylation of MAPK3 protein

PMID:16572112 PMID:19268487

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

increases phosphorylation

Superoxides results in increased phosphorylation of MAPK8 protein

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

increases phosphorylation

Superoxides results in increased phosphorylation of MAPK9 protein

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

myeloperoxidase

multiple interactions

[MPO protein results in increased oxidation of hydrazine] which results in increased chemical synthesis of Superoxides

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

metallothionein 3

decreases response to substance

MT3 protein results in decreased susceptibility to Superoxides

NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088

G

neutrophil cytosolic factor 1

multiple interactions

NCF1 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides]

NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315

G

neutrophil cytosolic factor 2

multiple interactions

NCF2 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides]

NCBI chr 1:183,555,562...183,601,849
Ensembl chr 1:183,554,461...183,590,905

G

nitric oxide synthase 2

multiple interactions

[Ozone results in increased expression of NOS2 protein] which results in increased abundance of Superoxides

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

nitric oxide synthase 3

multiple interactions
affects chemical synthesis
decreases abundance
increases abundance

7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; [Equol results in increased chemical synthesis of Superoxides] which results in increased activity of and results in increased phosphorylation of NOS3 protein; sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Equol results in increased chemical synthesis of Superoxides] which results in increased phosphorylation of NOS3 protein]
NOS3 protein affects the chemical synthesis of Superoxides
NOS3 protein results in decreased abundance of Superoxides
[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]
[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]

PMID:10625313 PMID:17272743 PMID:18714161 PMID:19011239 PMID:19696404 More...

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

NADPH oxidase 1

multiple interactions
increases abundance

[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mRNA promotes the reaction [Tobacco Smoke Pollution results in increased chemical synthesis of Superoxides]
diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]

PMID:23824088 PMID:23940720 PMID:24912985 PMID:27816504

NCBI chr X:100,843,324...100,874,359
Ensembl chr X:100,843,324...100,874,359

G

NADPH oxidase 3

multiple interactions

[resveratrol results in decreased expression of and results in decreased activity of NOX3 protein] which results in decreased abundance of Superoxides

NCBI chr 6:155,395,368...155,455,839
Ensembl chr 6:155,395,368...155,455,839

G

NADPH oxidase 4

multiple interactions

NOX4 promotes the reaction [sodium arsenite results in increased abundance of Superoxides]

NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187

G

Parkinsonism associated deglycase

multiple interactions

PARK7 protein affects the reaction [Paraquat results in increased abundance of Superoxides]

NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505

G

pyruvate dehydrogenase E1 subunit alpha 1

affects abundance

PDHA1 protein affects the abundance of Superoxides

NCBI chr X:19,343,927...19,361,718
Ensembl chr X:19,343,893...19,361,718

G

PTEN induced kinase 1

affects abundance

PINK1 protein affects the abundance of Superoxides

NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511

G

DNA polymerase gamma, catalytic subunit

multiple interactions
increases chemical synthesis

Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin inhibits the reaction [POLG protein results in increased chemical synthesis of Superoxides]; polyethylene glycol-superoxide dismutase inhibits the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]; Rotenone promotes the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]

NCBI chr15:89,316,320...89,334,824
Ensembl chr15:89,305,198...89,334,861

G

proopiomelanocortin

increases abundance

POMC protein results in increased abundance of Superoxides

NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903

G

paraoxonase 2

increases expression

Superoxides results in increased expression of PON2 protein

NCBI chr 7:95,404,862...95,435,028
Ensembl chr 7:95,404,862...95,435,329

G

cytochrome p450 oxidoreductase

multiple interactions

[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; [POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]

NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855

G

protein kinase C alpha

multiple interactions

[Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]

NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743

G

protein kinase C beta

multiple interactions

[Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]

NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

resveratrol inhibits the reaction [Superoxides results in increased expression of PTGS2 protein]

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

ribosomal protein S6 kinase B1

multiple interactions

[resveratrol results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

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selenoprotein H

decreases abundance

SELENOH protein results in decreased abundance of Superoxides

NCBI chr11:57,741,491...57,743,550
Ensembl chr11:57,741,491...57,743,554

G

serpin family E member 1

multiple interactions

[[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

sirtuin 1

multiple interactions

SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]]

NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390

G

solute carrier family 25 member 14

multiple interactions

SLC25A14 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Superoxides]; SLC25A14 protein inhibits the reaction [Dopamine results in increased abundance of Superoxides]

NCBI chr X:130,339,919...130,373,357
Ensembl chr X:130,339,888...130,373,361

G

sphingomyelin phosphodiesterase 1

multiple interactions

SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides]

NCBI chr11:6,390,474...6,394,996
Ensembl chr11:6,390,440...6,394,998

G

superoxide dismutase 1

increases abundance
decreases abundance
multiple interactions
decreases chemical synthesis

SOD1 protein results in increased abundance of Superoxides
SOD1 protein results in decreased abundance of Superoxides
[[Chelating Agents binds to Copper] which affects the activity of SOD1 protein] which results in increased abundance of Superoxides; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]
SOD1 protein results in decreased chemical synthesis of Superoxides
[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]

PMID:11756504 PMID:12489993 PMID:15364863 PMID:15829915 PMID:17391658 More...

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

increases metabolic processing
affects metabolic processing
decreases abundance
multiple interactions
increases expression
affects abundance
affects chemical synthesis

SOD2 protein results in increased metabolism of Superoxides
SOD2 protein polymorphism affects the metabolism of Superoxides
SOD2 protein results in decreased abundance of Superoxides
[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of SOD2 protein; SOD2 protein affects the reaction [Troglitazone results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [sodium arsenite results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]
Superoxides results in increased expression of SOD2 protein
[Rotenone results in increased abundance of Superoxides] which results in increased expression of SOD2 protein; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
[SOD2 protein results in increased metabolism of Superoxides] which results in increased chemical synthesis of Hydrogen Peroxide; Tamoxifen inhibits the reaction [SOD2 protein affects the abundance of Superoxides]
SOD2 protein affects the chemical synthesis of Superoxides

PMID:1850207 PMID:9067545 PMID:11050244 PMID:16179351 PMID:17150972 More...

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

superoxide dismutase 3

multiple interactions

[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; [Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Superoxides; SOD3 gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]

PMID:16864745 PMID:23884884

NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842

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transforming growth factor beta 1

multiple interactions
increases secretion
increases abundance

Superoxides affects the reaction [Glucose results in increased expression of TGFB1 mRNA]
Superoxides results in increased secretion of TGFB1 protein
[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein]
TGFB1 protein results in increased abundance of Superoxides

PMID:12606818 PMID:16572112 PMID:19268487

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tumor necrosis factor

multiple interactions
affects abundance
decreases abundance
increases abundance

[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein; [N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Superoxides]; cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Cyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]
TNF protein affects the abundance of Superoxides
TNF gene mutant form results in decreased abundance of Superoxides
TNF protein inhibits the reaction [Dichloroacetic Acid results in increased abundance of Superoxides]

PMID:1850207 PMID:11121130 PMID:11313892 PMID:15450858 PMID:19478208 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

thioredoxin

multiple interactions

[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]

NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507

G

thioredoxin reductase 1

multiple interactions

[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; [TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dinitrochlorobenzene promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; formic acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Oxygen deficiency inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Pentetic Acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Sodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

uncoupling protein 1

multiple interactions

UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]

NCBI chr 4:140,559,431...140,568,961
Ensembl chr 4:140,559,431...140,568,961

G

uncoupling protein 2

multiple interactions
decreases abundance

[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA
UCP2 protein results in decreased abundance of Superoxides

PMID:10860543 PMID:25440059

NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,061...73,982,843

G

vav guanine nucleotide exchange factor 2

multiple interactions
increases abundance

2-acetylphenothiazine inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]

NCBI chr 9:133,761,894...133,992,324
Ensembl chr 9:133,761,894...133,992,604

G

vitamin D receptor

decreases abundance

VDR protein results in decreased abundance of Superoxides

NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048

G

xanthine dehydrogenase

multiple interactions
increases chemical synthesis

[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides]

PMID:19268487 PMID:19555678

NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26503
chemical entity	26483
molecular entity	26465
inorganic molecular entity	25618
inorganic radical	499
inorganic radical ion	98
inorganic radical anion +	98
inorganic radical cation +	0

paths to the root