POLG (DNA polymerase gamma, catalytic subunit)

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Gene: POLG (DNA polymerase gamma, catalytic subunit) Homo sapiens

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Symbol:

POLG

Name:

DNA polymerase gamma, catalytic subunit

RGD ID:

732179

HGNC Page

HGNC:9179

Description:

Enables several functions, including 3'-5' exonuclease activity; DNA-directed DNA polymerase activity; and protease binding activity. Involved in mitochondrial DNA replication. Acts upstream of or within base-excision repair, gap-filling. Located in extracellular space; mitochondrial nucleoid; and nucleolus. Part of gamma DNA polymerase complex. Implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

dna polymerase gamma; DNA polymerase subunit gamma-1; FLJ27114; MDP1; MIRAS; mitochondrial DNA polymerase catalytic subunit; mitochondrial DNA polymerase gamma catalytic subunit; mitochondrial polymerase gamma catalytic subunit; MTDPS4A; MTDPS4B; ORF-Y; PEO; PolG, catalytic subunit; PolG-alpha; POLG1; POLGA; POLGARF; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit; SANDO; SCAE; truncated mitochondrial DNA polymerase gamma catalytic subunit; truncated mitochondrial polymerase gamma catalytic subunit

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Polg (polymerase (DNA directed), gamma)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Rattus norvegicus (Norway rat):	Polg (DNA polymerase gamma, catalytic subunit)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Chinchilla lanigera (long-tailed chinchilla):	Polg (DNA polymerase gamma, catalytic subunit)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	POLG (DNA polymerase gamma, catalytic subunit)	NCBI	Ortholog
Canis lupus familiaris (dog):	POLG (DNA polymerase gamma, catalytic subunit)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Polg (DNA polymerase gamma, catalytic subunit)	NCBI	Ortholog
Sus scrofa (pig):	POLG (DNA polymerase gamma, catalytic subunit)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther
Chlorocebus sabaeus (green monkey):	POLG (DNA polymerase gamma, catalytic subunit)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Polg (DNA polymerase gamma, catalytic subunit)	NCBI	Ortholog
Other homologs ²
Rattus norvegicus (Norway rat):	Baalc (BAALC binder of MAP3K1 and KLF4)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Polg (DNA polymerase gamma, catalytic subunit)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Polg (polymerase (DNA directed), gamma)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	polg (polymerase (DNA directed), gamma)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	MIP1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	polg-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	tam	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	polg.L	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	polg	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	89,316,320 - 89,334,824 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	15	89,305,198 - 89,334,861 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	89,859,551 - 89,878,055 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	87,660,554 - 87,679,030 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	87,660,552 - 87,679,030	NCBI
Celera	15	66,260,895 - 66,279,201 (-)	NCBI		Celera
Cytogenetic Map	15	q26.1	NCBI
HuRef	15	65,971,419 - 65,989,730 (-)	NCBI		HuRef
CHM1_1	15	89,700,576 - 89,719,066 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	87,071,147 - 87,089,647 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar