POLG (DNA polymerase gamma, catalytic subunit) - Rat Genome Database

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Gene: POLG (DNA polymerase gamma, catalytic subunit) Homo sapiens
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Symbol: POLG
Name: DNA polymerase gamma, catalytic subunit
RGD ID: 732179
HGNC Page HGNC:9179
Description: Enables several functions, including catalytic activity, acting on DNA; chromatin binding activity; and protease binding activity. Involved in DNA replication proofreading; base-excision repair; and mitochondrial DNA replication. Acts upstream of or within base-excision repair, gap-filling. Located in mitochondrial nucleoid. Part of gamma DNA polymerase complex. Implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 3'-5' exodeoxyribonuclease; 5'-deoxyribose-phosphate lyase; dna polymerase gamma; DNA polymerase subunit gamma-1; FLJ27114; MDP1; MIRAS; mitochondrial DNA polymerase catalytic subunit; mitochondrial DNA polymerase gamma catalytic subunit; mitochondrial polymerase gamma catalytic subunit; MTDPS4A; MTDPS4B; ORF-Y; PEO; PolG, catalytic subunit; PolG-alpha; POLG1; POLGA; POLGARF; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit; SANDO; SCAE; truncated mitochondrial DNA polymerase gamma catalytic subunit; truncated mitochondrial polymerase gamma catalytic subunit
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381589,316,320 - 89,334,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1589,305,198 - 89,334,861 (-)EnsemblGRCh38hg38GRCh38
GRCh371589,859,551 - 89,878,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,660,554 - 87,679,030 (-)NCBINCBI36Build 36hg18NCBI36
Build 341587,660,552 - 87,679,030NCBI
Celera1566,260,895 - 66,279,201 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1565,971,419 - 65,989,730 (-)NCBIHuRef
CHM1_11589,700,576 - 89,719,066 (-)NCBICHM1_1
T2T-CHM13v2.01587,071,147 - 87,089,647 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model