Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:protein tyrosine phosphatase activity
go back to main search page
Accession:GO:0004725 term browser browse the term
Definition:Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Synonyms:related_synonym: PPT-phosphatase activity;   PTP-phosphatase activity;   PTPase activity;   phosphoprotein phosphatase (phosphotyrosine) activity;   phosphotyrosine histone phosphatase activity;   phosphotyrosine phosphatase activity;   phosphotyrosine protein phosphatase activity;   phosphotyrosylprotein phosphatase activity;   protein-tyrosine-phosphate phosphohydrolase activity;   tyrosine O-phosphate phosphatase activity;   tyrosylprotein phosphatase activity
 xref: EC:3.1.3.48;   MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN;   RHEA:10684;   Reactome:R-HSA-8867658 "PTPN3 dephosphorylates MAPK12";   Reactome:R-HSA-9635461 "PtpA dephosphorylates GSK3A";   Reactome:R-HSA-9636439 "PtpA:Ub dephosphorylates p-Y133-VPS33B";   Reactome:R-HSA-9674816 "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS";   Reactome:R-HSA-9698408 "PTPRJ dephosphorylates active FLT3";   Reactome:R-HSA-9700200 "PTPRZ dephosphorylates ligand-bound ALK dimers";   Reactome:R-HSA-9701507 "PTPN6 dephosphorylates JAK3";   reactome:R-HSA-1169188 "SHP1 (PTPN6) dephosphorylates JAK2";   reactome:R-HSA-1169192 "PTP1B dephosphorylates GHR";   reactome:R-HSA-1169210 "PTP1B dephosphorylates JAK2";   reactome:R-HSA-1549564 "PPTN11 dephosphorylates SPRY2";   reactome:R-HSA-202214 "Dephosphorylation of Lck-pY505 by CD45";   reactome:R-HSA-203797 "ERKs are inactivated by dual-specific phosphatases (DUSPs)";   reactome:R-HSA-377643 "Dephosphorylation of inactive SRC by PTPB1";   reactome:R-HSA-389758 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases";   reactome:R-HSA-391868 "Dephosphorylation of NCAM1 bound pFyn";   reactome:R-HSA-445089 "Dephosphorylation of pL1 (Y1176)";   reactome:R-HSA-5683967 "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX";   reactome:R-HSA-6807008 "PTPRJ dephosphorylates MET";   reactome:R-HSA-6807027 "PTPN1 and PTPN2 dephosphorylate MET";   reactome:R-HSA-74733 "Insulin receptor de-phosphorylation";   reactome:R-HSA-74747 "Dephosphorylation of p-Y-IRS1,p-Y-IRS2";   reactome:R-HSA-74748 "De-phosphorylation of p-Y427-SHC1";   reactome:R-HSA-877308 "Dephosphorylation of JAKs by PTPs";   reactome:R-HSA-8849435 "PTPN1 dephosphorylates PTK6";   reactome:R-HSA-8852200 "Inactivation of LCK by PTPN22";   reactome:R-HSA-8855381 "PTPN22 dephosphorylates ZAP70";   reactome:R-HSA-8863804 "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248";   reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1148 (Y1172)";   reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021";   reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248";   reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15";   reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1";   reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB";   reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3";   reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2";   reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B";   reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1";   reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP"


show annotations for term's descendants           Sort by:
protein tyrosine phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07041247.1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002
G Acp1 acid phosphatase 1 enables IDA
IBA
ISO		 GO_REF:0000033
(PMID:9705307)		 GO_Central
RGD		 PMID:9705307 PMID:7686862 GO_REF:0000033, RGD:1598713 NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021 		JBrowse link
G Acp3 acid phosphatase 3 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Acp4 acid phosphatase 4 enables ISO
IBA		 (PMID:15219672)
GO_REF:0000033		 RGD
GO_Central		 PMID:15219672 GO_REF:0000033 NCBI chr 1:94,736,376...94,751,871
Ensembl chr 1:94,735,514...94,744,623 		JBrowse link
G Cdc14a cell division cycle 14A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:204,225,540...204,380,927
Ensembl chr 2:204,225,540...204,380,927 		JBrowse link
G Cdc14b cell division cycle 14B enables ISO
IBA		 (PMID:9367992)
GO_REF:0000033		 RGD
GO_Central		 PMID:9367992 GO_REF:0000033 NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235 		JBrowse link
G Cdc25a cell division cycle 25A enables IEA
ISO
IBA		 GO_REF:0000003
(PMID:20360007)
GO_REF:0000033
GO_REF:0000104		 UniProt
RGD
GO_Central		 PMID:20360007 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdc25b cell division cycle 25B enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000104		 UniProt
GO_Central		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272 		JBrowse link
G Cdc25c cell division cycle 25C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 enables ISO
IBA
IEA		 (PMID:8242750)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:8242750 GO_REF:0000033 GO_REF:0000107 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945 		JBrowse link
G Dusp1 dual specificity phosphatase 1 enables ISO
ISS		 (PMID:1406996)
(MGI:62859|PMID:8355678)
GO_REF:0000024		 RGD
UniProt		 PMID:1406996 PMID:8355678 GO_REF:0000024 MGI:62859 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp11 dual specificity phosphatase 11 enables ISO (PMID:9685386) RGD PMID:9685386 NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181 		JBrowse link
G Dusp12 dual specificity phosphatase 12 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr13:83,122,192...83,131,800
Ensembl chr13:83,122,193...83,131,285 		JBrowse link
G Dusp13a dual specificity phosphatase 13A enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr15:2,559,763...2,562,379 JBrowse link
G Dusp14 dual specificity phosphatase 14 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329 		JBrowse link
G Dusp14l1 dual specificity phosphatase 14-like 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:138,738,130...138,739,473
Ensembl chr 2:138,738,101...138,739,486 		JBrowse link
G Dusp15 dual specificity phosphatase 15 enables ISO
IBA
IEA		 (PMID:22792334)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:22792334 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:141,408,495...141,419,137
Ensembl chr 3:141,408,498...141,418,999 		JBrowse link
G Dusp18 dual specificity phosphatase 18 enables ISO
IBA
IEA		 (PMID:12408986)
GO_REF:0000033
GO_REF:0000003		 RGD
GO_Central
UniProt		 PMID:12408986 GO_REF:0000003 GO_REF:0000033 NCBI chr14:78,790,183...78,811,576
Ensembl chr14:78,787,505...78,811,576 		JBrowse link
G Dusp21 dual specificity phosphatase 21 enables ISO
IBA		 (PMID:12408986)
GO_REF:0000033		 RGD
GO_Central		 PMID:12408986 GO_REF:0000033 NCBI chr  X:4,488,021...4,488,877
Ensembl chr  X:4,488,021...4,488,877 		JBrowse link
G Dusp22 dual specificity phosphatase 22 enables ISO
IBA		 (PMID:24714587)
GO_REF:0000033		 RGD
GO_Central		 PMID:24714587 GO_REF:0000033 NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321 		JBrowse link
G Dusp23 dual specificity phosphatase 23 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:85,097,899...85,100,054
Ensembl chr13:85,097,899...85,100,093 		JBrowse link
G Dusp26 dual specificity phosphatase 26 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr16:61,041,784...61,049,319
Ensembl chr16:61,041,792...61,049,051 		JBrowse link
G Dusp29 dual specificity phosphatase 29 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr15:2,593,473...2,634,019
Ensembl chr15:2,593,578...2,633,503 		JBrowse link
G Dusp3 dual specificity phosphatase 3 enables ISO (PMID:11863439), (PMID:28759036) RGD PMID:11863439 PMID:28759036 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Dusp4 dual specificity phosphatase 4 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000003
(PMID:7535768)		 UniProt
RGD		 PMID:7535768 GO_REF:0000003 GO_REF:0000024 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138 		JBrowse link
G Dusp5 dual specificity phosphatase 5 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G ENSRNOG00000065158 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 1:70,917,514...70,918,195 JBrowse link
G Epm2a EPM2A glucan phosphatase, laforin enables ISO
IBA
IEA		 (PMID:11001928), (PMID:11739371), (PMID:12915448)
(PMID:15541350)
GO_REF:0000033
GO_REF:0000117		 RGD
GO_Central
UniProt		 PMID:11001928 PMID:11739371 PMID:12915448 PMID:15541350 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:5,727,111...5,845,338
Ensembl chr 1:5,727,066...5,920,555 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 enables IBA
ISO		 GO_REF:0000033
(PMID:14628052), (PMID:21385765)		 GO_Central
RGD		 PMID:14628052 PMID:21385765 GO_REF:0000033 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 enables IBA
ISO		 GO_REF:0000033
(PMID:14628052)		 GO_Central
RGD		 PMID:14628052 GO_REF:0000033 NCBI chr 3:154,335,598...154,519,006
Ensembl chr 3:154,335,400...154,518,793 		JBrowse link
G Eya3 EYA transcriptional coactivator and phosphatase 3 enables ISO
IBA		 (PMID:19234442), (PMID:19351884)
(PMID:14628052)
GO_REF:0000033		 RGD
GO_Central		 PMID:14628052 PMID:19234442 PMID:19351884 GO_REF:0000033 NCBI chr 5:144,806,523...144,934,522
Ensembl chr 5:144,806,577...144,934,518 		JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:22,172,275...22,415,978
Ensembl chr 1:22,172,275...22,415,976 		JBrowse link
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 NOT|enables ISO (PMID:15024066) RGD PMID:15024066 NCBI chr11:65,667,671...65,762,903
Ensembl chr11:65,670,281...65,762,889 		JBrowse link
G Mtmr3 myotubularin related protein 3 enables ISO
IEA		 (PMID:10733931)
GO_REF:0000107
GO_REF:0000003		 RGD
Ensembl
UniProt		 PMID:10733931 GO_REF:0000003 GO_REF:0000107 NCBI chr14:79,340,523...79,460,947
Ensembl chr14:79,340,513...79,461,041 		JBrowse link
G Mtmr4 myotubularin related protein 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:72,393,411...72,416,342
Ensembl chr10:72,392,551...72,416,342 		JBrowse link
G Pald1 phosphatase domain containing, paladin 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:29,269,814...29,334,850
Ensembl chr20:29,270,193...29,334,858 		JBrowse link
G Pgp phosphoglycolate phosphatase enables ISO (MGI:5545857|PMID:24338473) RGD PMID:24338473 MGI:5545857 NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha enables ISO (PMID:15525651) RGD PMID:15525651 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Pten phosphatase and tensin homolog enables ISO
IBA
IEA		 (PMID:9256433)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:9256433 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptk2 protein tyrosine kinase 2 enables ISO (PMID:9360983) RGD PMID:9360983 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 enables IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro
RGD		 PMID:8196618 GO_REF:0000002 GO_REF:0000033, RGD:61722 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964 		JBrowse link
G Ptp4a1l1 protein tyrosine phosphatase 4A1 like 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:116,789,584...116,790,544
Ensembl chr  X:116,789,935...116,790,456 		JBrowse link
G Ptp4a1l3 protein tyrosine phosphatase 4A1 like 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:137,876,096...137,876,672
Ensembl chr  X:137,876,160...137,876,672 		JBrowse link
G Ptp4a2 protein tyrosine phosphatase 4A2 enables IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:142,165,405...142,192,412
Ensembl chr 5:142,165,700...142,191,899 		JBrowse link
G Ptp4a2l1 protein tyrosine phosphatase 4A2 like 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:17,530,517...17,532,146
Ensembl chr 5:17,530,395...17,532,150 		JBrowse link
G Ptp4a3 protein tyrosine phosphatase 4A3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:105,650,640...105,660,921
Ensembl chr 7:105,628,029...105,660,919 		JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 3:76,889,922...76,899,427
Ensembl chr 3:76,889,922...76,899,427 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 enables IMP
IEA
ISO
IDA		 GO_REF:0000002
MGI:2384135 (PMID:15632081), (PMID:17068137)
(PMID:18074158), (PMID:21707536), (PMID:22169477)		 InterPro
RGD		 PMID:15632081 PMID:17068137 PMID:18074158 PMID:21707536 PMID:22169477 More... GO_REF:0000002, RGD:2289367, RGD:2293185 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 enables IDA
IEA
ISO		 GO_REF:0000002
(PMID:18827006)
(PMID:10206955), (PMID:15133037), (PMID:17562706), (PMID:22759635), (PMID:23029125), (PMID:26617336), (PMID:26742426), (PMID:28074573)		 InterPro
RGD		 PMID:10206955 PMID:15133037 PMID:17562706 PMID:18827006 PMID:22759635 More... GO_REF:0000002, RGD:729786, RGD:2293185, RGD:1601573, RGD:1581313 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 enables IDA
IBA
ISO		 GO_REF:0000033
(PMID:21376233)		 GO_Central
RGD		 PMID:21376233 PMID:7957881 GO_REF:0000033, RGD:633766 NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 enables ISO
IBA		 (PMID:14516276), (PMID:15611135), (PMID:19307596), (PMID:23604317)
GO_REF:0000033		 RGD
GO_Central		 PMID:14516276 PMID:15611135 PMID:19307596 PMID:23604317 GO_REF:0000033 NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563 		JBrowse link
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 enables ISO
IBA		 (PMID:22525271)
GO_REF:0000033		 RGD
GO_Central		 PMID:22525271 GO_REF:0000033 NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088 		JBrowse link
G Ptpn18 protein tyrosine phosphatase, non-receptor type 18 enables ISO
IBA		 (PMID:25081058)
GO_REF:0000033		 RGD
GO_Central		 PMID:25081058 GO_REF:0000033 NCBI chr 9:36,672,325...36,689,963
Ensembl chr 9:36,672,362...36,690,995 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000002
GO_REF:0000107
(PMID:17210636)
(MGI:3029644|PMID:14966296), (PMID:15632081)
(PMID:12138178)
(PMID:11909529), (PMID:12612081), (PMID:14966296)
(PMID:23006999)		 UniProt
InterPro
Ensembl
RGD		 PMID:11909529 PMID:12138178 PMID:12612081 PMID:14966296 PMID:15632081 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 MGI:3029644 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptpn20 protein tyrosine phosphatase, non-receptor type 20 NOT|enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:8,885,585...8,949,805
Ensembl chr16:8,893,324...8,949,783 		JBrowse link
G Ptpn21 protein tyrosine phosphatase, non-receptor type 21 enables IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000104
GO_REF:0000116
GO_REF:0000003		 GO_Central
UniProt
RHEA
RGD		 PMID:7805871 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116, RGD:633837 NCBI chr 6:117,933,066...117,998,095
Ensembl chr 6:117,933,066...117,998,095 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:5792478|PMID:27043286)
(PMID:10068674), (PMID:16461343), (PMID:18056643), (PMID:27043286)		 BHF-UCL
GO_Central
RGD		 PMID:10068674 PMID:16461343 PMID:18056643 PMID:27043286 GO_REF:0000024 GO_REF:0000033 MGI:5792478 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Ptpn23 protein tyrosine phosphatase, non-receptor type 23 enables ISO
IEA		 (PMID:21724833)
GO_REF:0000107		 RGD
Ensembl		 PMID:21724833 GO_REF:0000107 NCBI chr 8:110,360,804...110,383,271
Ensembl chr 8:110,360,804...110,383,271 		JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 enables ISO
IBA		 (PMID:19167335)
GO_REF:0000033		 RGD
GO_Central		 PMID:19167335 GO_REF:0000033 NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443 		JBrowse link
G Ptpn4 protein tyrosine phosphatase, non-receptor type 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 enables IDA
ISO
IBA
IEA		 (PMID:16025111)
GO_REF:0000033
GO_REF:0000003		 RGD
GO_Central
UniProt		 PMID:16025111 PMID:19625523 GO_REF:0000003 GO_REF:0000033, RGD:9835004 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 enables TAS
IEA
ISO		 GO_REF:0000002
GO_REF:0000003
(MGI:6294631|PMID:10556798), (PMID:10585470), (PMID:11266449), (PMID:27830702), (PMID:8632004), (PMID:8943354), (PMID:9064344)
(PMID:10206955), (PMID:17562706)		 InterPro
UniProt
RGD		 PMID:8632004 PMID:8943354 PMID:9064344 PMID:10206955 PMID:10556798 More... GO_REF:0000002 GO_REF:0000003 MGI:6294631, RGD:1302222 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Ptpn7 protein tyrosine phosphatase, non-receptor type 7 enables IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr13:46,570,904...46,584,048
Ensembl chr13:46,571,712...46,583,308 		JBrowse link
G Ptpn9 protein tyrosine phosphatase, non-receptor type 9 enables IDA
IBA
IEA
ISO
ISS		 GO_REF:0000033
GO_REF:0000002
(PMID:19167335), (PMID:27655914)
GO_REF:0000024		 GO_Central
InterPro
RGD
UniProt		 PMID:19167335 PMID:27655914 PMID:11971009 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033, RGD:708311 NCBI chr 8:57,391,290...57,472,352
Ensembl chr 8:57,391,259...57,470,952 		JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A enables IDA
IBA
IEA
ISO
ISS		 GO_REF:0000033
GO_REF:0000107
(MGI:5442237|PMID:22801373)
GO_REF:0000024
GO_REF:0000116
GO_REF:0000003		 GO_Central
Ensembl
RGD
UniProt
RHEA		 PMID:22801373 PMID:19812040 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 MGI:5442237, RGD:2314625 NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728 		JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B enables IEA GO_REF:0000003
GO_REF:0000117		 UniProt GO_REF:0000003 GO_REF:0000117 NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C enables ISO
IBA
IEA
ISS
IGI		 (PMID:2853967)
UniProtKB:P01830|UniProtKB:P04157|UniProtKB:P08921|UniProtKB:P13838 (MGI:6201809|PMID:12496963), (PMID:25074919), (PMID:7743522), (PMID:8566025)
GO_REF:0000033
GO_REF:0000117
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:2853967 PMID:7743522 PMID:8566025 PMID:12496963 PMID:25074919 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 MGI:6201809, RGD:1358565 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396 		JBrowse link
G Ptpre protein tyrosine phosphatase, receptor type, E enables NAS
ISO
IBA
IEA		 (PMID:12861030)
GO_REF:0000033
GO_REF:0000002		 RGD
GO_Central
InterPro		 PMID:12861030 PMID:8579581 GO_REF:0000002 GO_REF:0000033, RGD:633852 NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F enables IDA
IBA
IEA
ISS
ISO		 GO_REF:0000033
GO_REF:0000117
GO_REF:0000024
GO_REF:0000003
(PMID:10338209), (PMID:23358419)		 GO_Central
UniProt
RGD		 PMID:10338209 PMID:23358419 PMID:8068021 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000117, RGD:69951 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Ptprg protein tyrosine phosphatase, receptor type, G enables NAS
IBA
ISO		 GO_REF:0000033
(PMID:19167335)		 GO_Central
RGD		 PMID:19167335 PMID:9016795 GO_REF:0000033, RGD:633859 NCBI chr15:12,871,706...13,552,186
Ensembl chr15:12,871,721...13,554,094 		JBrowse link
G Ptprh protein tyrosine phosphatase, receptor type, H enables IEA
IBA		 GO_REF:0000117
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:69,243,704...69,276,294
Ensembl chr 1:69,242,321...69,285,077 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J enables ISO
IBA		 (PMID:10821867), (PMID:12475979), (PMID:12913111), (PMID:18348712), (PMID:18936167), (PMID:19332538), (PMID:9531590), (PMID:9780142)
GO_REF:0000033
(MGI:4942251|PMID:12771128)		 RGD
GO_Central		 PMID:9531590 PMID:9780142 PMID:10821867 PMID:12475979 PMID:12771128 More... GO_REF:0000033 MGI:4942251 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Ptprk protein tyrosine phosphatase, receptor type, K enables TAS
ISO
IBA		 (PMID:8474452)
GO_REF:0000033
(PMID:16263724), (PMID:16849327), (PMID:8663237)		 RGD
GO_Central		 PMID:8474452 PMID:8663237 PMID:16263724 PMID:16849327 PMID:10383829 GO_REF:0000033, RGD:634006 NCBI chr 1:16,738,896...17,236,687
Ensembl chr 1:16,850,576...17,103,605 		JBrowse link
G Ptprm protein tyrosine phosphatase, receptor type, M enables ISO
IBA		 (PMID:17965016), (PMID:18566238), (PMID:8393854)
GO_REF:0000033		 RGD
GO_Central		 PMID:8393854 PMID:17965016 PMID:18566238 GO_REF:0000033 NCBI chr 9:106,639,573...107,343,698
Ensembl chr 9:106,639,573...107,343,698 		JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N NOT|enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:8878556)
GO_REF:0000002		 UniProt
RGD
InterPro		 PMID:8878556 GO_REF:0000002 GO_REF:0000024 NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190 		JBrowse link
G Ptprn2 protein tyrosine phosphatase, receptor type N2 enables IEA GO_REF:0000003
GO_REF:0000002
GO_REF:0000116		 UniProt
InterPro
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr 6:137,439,572...138,191,575
Ensembl chr 6:137,439,540...138,191,575 		JBrowse link
G Ptpro protein tyrosine phosphatase, receptor type, O enables IDA
IBA
ISO
ISS		 GO_REF:0000033
(MGI:3577156|PMID:15673668)
GO_REF:0000024
(PMID:19167335), (PMID:19233845)		 GO_Central
RGD
UniProt		 PMID:15673668 PMID:19167335 PMID:19233845 PMID:9032477 GO_REF:0000024 GO_REF:0000033 MGI:3577156, RGD:61725 NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771 		JBrowse link
G Ptprq protein tyrosine phosphatase, receptor type, Q enables IEA GO_REF:0000003
GO_REF:0000117
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr 7:42,834,455...43,016,807
Ensembl chr 7:42,837,109...43,016,917 		JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R enables TAS
ISO
IBA
IEA		 (PMID:7832766)
GO_REF:0000033
GO_REF:0000003		 RGD
GO_Central
UniProt		 PMID:7832766 PMID:7814416 GO_REF:0000003 GO_REF:0000033, RGD:729713 NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603 		JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S enables IDA
ISO
IBA
IEA		 (MGI:70512|PMID:7529177), (PMID:24385580)
GO_REF:0000033
GO_REF:0000117
GO_REF:0000003		 RGD
GO_Central
UniProt		 PMID:7529177 PMID:24385580 PMID:8068021 GO_REF:0000003 GO_REF:0000033 GO_REF:0000117 MGI:70512, RGD:69951 NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947 		JBrowse link
G Ptprt protein tyrosine phosphatase, receptor type, T enables ISO
IBA		 (PMID:16973135), (PMID:17360477)
GO_REF:0000033		 RGD
GO_Central		 PMID:16973135 PMID:17360477 GO_REF:0000033 NCBI chr 3:150,189,343...151,288,145
Ensembl chr 3:150,194,859...151,288,124 		JBrowse link
G Ptpru protein tyrosine phosphatase, receptor type, U enables ISO
IBA		 (PMID:12501215), (PMID:16574648)
GO_REF:0000033		 RGD
GO_Central		 PMID:12501215 PMID:16574648 GO_REF:0000033 NCBI chr 5:143,950,542...144,024,791
Ensembl chr 5:143,950,965...144,024,768 		JBrowse link
G Ptprv protein tyrosine phosphatase, receptor type, V enables IEA
IBA
IMP		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000117		 UniProt
GO_Central
RGD		 PMID:7527035 GO_REF:0000003 GO_REF:0000033 GO_REF:0000117, RGD:632779 NCBI chr13:46,548,125...46,569,148
Ensembl chr13:46,548,128...46,568,329 		JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 enables IDA
IBA
IEA
ISO
ISS		 GO_REF:0000033
GO_REF:0000117
(MGI:3622611|PMID:16513268)
PMID:16814777
GO_REF:0000003
GO_REF:0000024
(PMID:10706604)		 GO_Central
UniProt
RGD		 PMID:10706604 PMID:16513268 PMID:11381105 PMID:16814777 PMID:21890632 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 MGI:3622611, RGD:9589125, RGD:11344935, RGD:9590130 NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218 		JBrowse link
G Ssh3 slingshot protein phosphatase 3 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:201,557,167...201,565,577
Ensembl chr 1:201,557,169...201,564,753 		JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 enables ISO (PMID:15044455) RGD PMID:15044455 NCBI chr 1:83,574,872...83,582,748
Ensembl chr 1:83,556,757...83,582,793 		JBrowse link
G Tns2 tensin 2 enables ISO
IBA		 (PMID:23401856)
GO_REF:0000033		 RGD
GO_Central		 PMID:23401856 GO_REF:0000033 NCBI chr 7:133,229,746...133,247,889
Ensembl chr 7:133,206,364...133,247,888 		JBrowse link
G Tpte2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:69,658,874...69,756,571
Ensembl chr16:69,658,875...69,752,949 		JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B enables IBA
ISO		 GO_REF:0000033
(PMID:23149425), (PMID:27609517)		 GO_Central
RGD		 PMID:23149425 PMID:27609517 GO_REF:0000033 NCBI chr 8:41,385,419...41,532,248
Ensembl chr 8:41,388,341...41,532,201 		JBrowse link
MAP kinase tyrosine phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp1 dual specificity phosphatase 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp10 dual specificity phosphatase 10 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp16 dual specificity phosphatase 16 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980 		JBrowse link
G Dusp2 dual specificity phosphatase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499 		JBrowse link
G Dusp4 dual specificity phosphatase 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138 		JBrowse link
G Dusp5 dual specificity phosphatase 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Dusp6 dual specificity phosphatase 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Dusp7 dual specificity phosphatase 7 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:107,009,369...107,016,404
Ensembl chr 8:107,008,528...107,016,404 		JBrowse link
G Dusp8 dual specificity phosphatase 8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921 		JBrowse link
G Dusp9 dual specificity phosphatase 9 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:151,351,897...151,355,822
Ensembl chr  X:151,351,897...151,355,821 		JBrowse link
non-membrane spanning protein tyrosine phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp1 acid phosphatase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021 		JBrowse link
G Acp1l1 acid phosphatase 1 like 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:7,871,574...7,872,173 JBrowse link
G Dusp22 dual specificity phosphatase 22 enables ISO (PMID:20018849) RGD PMID:20018849 NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:10655584), (PMID:16481357)
GO_REF:0000107
GO_REF:0000033
MGI:3050284 (PMID:15273746)		 UniProt
RGD
Ensembl
GO_Central		 PMID:10655584 PMID:15273746 PMID:16481357 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927 		JBrowse link
G Ptpn18 protein tyrosine phosphatase, non-receptor type 18 enables ISO (PMID:8875997) RGD PMID:8875997 NCBI chr 9:36,672,325...36,689,963
Ensembl chr 9:36,672,362...36,690,995 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:8534367 GO_REF:0000033, RGD:729799 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Ptpn4 protein tyrosine phosphatase, non-receptor type 4 enables ISO (PMID:11054567) RGD PMID:11054567 NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
transmembrane receptor protein tyrosine phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:11266449)		 UniProt
Ensembl
RGD		 PMID:11266449 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C TAS RGD PMID:12496963 RGD:1358565 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IDA RGD PMID:7711057 RGD:2293185 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Ptprm protein tyrosine phosphatase, receptor type, M enables ISO
ISS		 (PMID:10809770)
GO_REF:0000024		 RGD
UniProt		 PMID:10809770 GO_REF:0000024 NCBI chr 9:106,639,573...107,343,698
Ensembl chr 9:106,639,573...107,343,698 		JBrowse link
G Ptprt protein tyrosine phosphatase, receptor type, T enables ISO (PMID:24846175) RGD PMID:24846175 NCBI chr 3:150,189,343...151,288,145
Ensembl chr 3:150,194,859...151,288,124 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      catalytic activity, acting on a protein 2444
        phosphoprotein phosphatase activity 177
          protein tyrosine phosphatase activity 98
            MAP kinase tyrosine phosphatase activity 10
            non-membrane spanning protein tyrosine phosphatase activity 11
            prenylated protein tyrosine phosphatase activity 0
            protein tyrosine phosphatase activity, metal-dependent 0
            protein tyrosine phosphatase activity, via thiol-phosphate intermediate 0
            transmembrane receptor protein tyrosine phosphatase activity 5
Path 2
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      hydrolase activity 2592
        hydrolase activity, acting on ester bonds 815
          phosphoric ester hydrolase activity 374
            phosphatase activity 283
              phosphoprotein phosphatase activity 177
                protein tyrosine phosphatase activity 98
                  MAP kinase tyrosine phosphatase activity 10
                  non-membrane spanning protein tyrosine phosphatase activity 11
                  prenylated protein tyrosine phosphatase activity 0
                  protein tyrosine phosphatase activity, metal-dependent 0
                  protein tyrosine phosphatase activity, via thiol-phosphate intermediate 0
                  transmembrane receptor protein tyrosine phosphatase activity 5
paths to the root