Ptpn21 (protein tyrosine phosphatase, non-receptor type 21) - Rat Genome Database

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Gene: Ptpn21 (protein tyrosine phosphatase, non-receptor type 21) Rattus norvegicus
Analyze
Symbol: Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
RGD ID: 620216
Description: Enables protein tyrosine phosphatase activity. Predicted to be involved in cytoskeleton organization. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human PTPN21 (protein tyrosine phosphatase non-receptor type 21); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: protein tyrosine phosphatase 2E; protein-tyrosine phosphatase 2E; Ptp2E; tyrosine-protein phosphatase non-receptor type 21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,662,783 - 123,727,809 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6123,662,783 - 123,727,809 (-)EnsemblGRCr8
mRatBN7.26117,933,066 - 117,998,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,933,066 - 117,998,095 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6118,083,639 - 118,148,672 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06118,380,435 - 118,445,473 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,715,307 - 117,780,330 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,656,500 - 122,721,496 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,656,500 - 122,721,496 (-)Ensemblrn6Rnor6.0
Rnor_5.06131,870,742 - 131,942,655 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46122,840,062 - 122,910,939 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6115,494,945 - 115,557,718 (-)NCBICelera
RGSC_v3.16122,843,808 - 122,914,686 (-)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
lead diacetate  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methylphenidate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phorone  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (EXP)
undecane  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytoskeleton  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Identification of a novel protein tyrosine phosphatase with sequence homology to the cytoskeletal proteins of the band 4.1 family. L'Abbe D, etal., FEBS Lett 1994 Dec 19;356(2-3):351-6.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15143158   PMID:19103603   PMID:28843827  


Genomics

Comparative Map Data
Ptpn21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,662,783 - 123,727,809 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6123,662,783 - 123,727,809 (-)EnsemblGRCr8
mRatBN7.26117,933,066 - 117,998,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,933,066 - 117,998,095 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6118,083,639 - 118,148,672 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06118,380,435 - 118,445,473 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,715,307 - 117,780,330 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,656,500 - 122,721,496 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,656,500 - 122,721,496 (-)Ensemblrn6Rnor6.0
Rnor_5.06131,870,742 - 131,942,655 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46122,840,062 - 122,910,939 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6115,494,945 - 115,557,718 (-)NCBICelera
RGSC_v3.16122,843,808 - 122,914,686 (-)NCBI
Cytogenetic Map6q32NCBI
PTPN21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381488,465,778 - 88,555,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1488,465,778 - 88,555,007 (-)Ensemblhg38GRCh38
GRCh371488,932,122 - 89,021,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361488,001,875 - 88,090,876 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341488,003,869 - 88,090,876NCBI
Celera1468,977,718 - 69,066,716 (-)NCBICelera
Cytogenetic Map14q31.3NCBI
HuRef1469,102,423 - 69,191,405 (-)NCBIHuRef
CHM1_11488,869,992 - 88,958,966 (-)NCBICHM1_1
T2T-CHM13v2.01482,686,590 - 82,775,829 (-)NCBIT2T-CHM13v2.0
Ptpn21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391298,643,000 - 98,703,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1298,643,000 - 98,703,664 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381298,676,741 - 98,737,613 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1298,676,741 - 98,737,405 (-)Ensemblmm10GRCm38
MGSCv371299,914,951 - 99,975,615 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361299,077,792 - 99,135,644 (-)NCBIMGSCv36mm8
Celera1299,901,870 - 99,962,936 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1249.88NCBI
Ptpn21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543811,090,044 - 11,153,310 (-)Ensembl
ChiLan1.0NW_00495543811,087,906 - 11,162,592 (-)NCBIChiLan1.0ChiLan1.0
PTPN21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21589,612,293 - 89,706,427 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11488,828,800 - 88,917,631 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01469,085,843 - 69,174,659 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11488,444,261 - 88,528,980 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1488,444,261 - 88,528,951 (-)EnsemblpanPan2panpan1.1
PTPN21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1859,707,192 - 59,783,185 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl859,708,972 - 59,782,459 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha859,285,172 - 59,364,633 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0859,976,521 - 60,056,056 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl859,976,546 - 60,051,844 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1859,655,290 - 59,735,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0859,701,218 - 59,780,673 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0860,034,791 - 60,114,624 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptpn21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864016,072,021 - 16,147,382 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648815,923,833 - 15,995,142 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648815,922,624 - 15,996,997 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7110,373,530 - 110,453,812 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17110,374,915 - 110,453,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27116,869,832 - 116,952,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12466,102,081 - 66,191,918 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2466,101,788 - 66,187,987 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605353,464,502 - 53,552,903 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473413,802,165 - 13,863,058 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473413,801,739 - 13,866,825 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptpn21
458 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:619
Count of miRNA genes:289
Interacting mature miRNAs:374
Transcripts:ENSRNOT00000065091
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat

Markers in Region
D6Rat160  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86123,706,755 - 123,707,119 (+)Marker Load Pipeline
mRatBN7.26117,977,041 - 117,977,405 (+)MAPPERmRatBN7.2
Rnor_6.06122,700,475 - 122,700,838NCBIRnor6.0
Celera6115,536,875 - 115,537,130UniSTS
RH 3.4 Map6870.09RGD
RH 3.4 Map6870.09UniSTS
RH 2.0 Map61015.8RGD
SHRSP x BN Map676.0298RGD
Cytogenetic Map6q32UniSTS
RH133445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26117,933,224 - 117,933,442 (+)MAPPERmRatBN7.2
Rnor_6.06122,656,659 - 122,656,876NCBIRnor6.0
Rnor_5.06131,870,901 - 131,871,118UniSTSRnor5.0
RGSC_v3.46122,840,221 - 122,840,438UniSTSRGSC3.4
Celera6115,495,104 - 115,495,321UniSTS
RH 3.4 Map6870.0UniSTS
Cytogenetic Map6q32UniSTS
BF389154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26117,983,970 - 117,984,165 (+)MAPPERmRatBN7.2
Rnor_6.06122,707,404 - 122,707,598NCBIRnor6.0
Rnor_5.06131,928,560 - 131,928,754UniSTSRnor5.0
RGSC_v3.46122,896,844 - 122,897,038UniSTSRGSC3.4
Celera6115,543,696 - 115,543,890UniSTS
RH 3.4 Map6884.9UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 83 59 6 347 183 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000079697   ⟹   ENSRNOP00000068645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,662,783 - 123,727,809 (-)Ensembl
mRatBN7.2 Ensembl6117,933,066 - 117,998,095 (-)Ensembl
Rnor_6.0 Ensembl6122,656,500 - 122,721,496 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096034   ⟹   ENSRNOP00000091190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,662,783 - 123,727,809 (-)Ensembl
mRatBN7.2 Ensembl6117,933,066 - 117,998,095 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000124426   ⟹   ENSRNOP00000099494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,662,783 - 123,704,781 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160230   ⟹   ENSRNOP00000104682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,662,783 - 123,727,809 (-)Ensembl
RefSeq Acc Id: NM_133545   ⟹   NP_598229
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,662,783 - 123,727,809 (-)NCBI
mRatBN7.26117,933,066 - 117,998,095 (-)NCBI
Rnor_6.06122,656,500 - 122,721,496 (-)NCBI
Rnor_5.06131,870,742 - 131,942,655 (-)NCBI
RGSC_v3.46122,840,062 - 122,910,939 (-)RGD
Celera6115,494,945 - 115,557,718 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594023   ⟹   XP_017449512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,662,783 - 123,724,972 (-)NCBI
mRatBN7.26117,934,416 - 117,995,221 (-)NCBI
Rnor_6.06122,657,850 - 122,718,758 (-)NCBI
Sequence:
RefSeq Acc Id: NP_598229   ⟸   NM_133545
- UniProtKB: Q62732 (UniProtKB/Swiss-Prot),   Q62728 (UniProtKB/Swiss-Prot),   A0A0G2JTB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449512   ⟸   XM_017594023
- Peptide Label: isoform X1
- UniProtKB: Q62732 (UniProtKB/Swiss-Prot),   Q62728 (UniProtKB/Swiss-Prot),   A0A0G2JTB7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068645   ⟸   ENSRNOT00000079697
Ensembl Acc Id: ENSRNOP00000091190   ⟸   ENSRNOT00000096034
Ensembl Acc Id: ENSRNOP00000104682   ⟸   ENSRNOT00000160230
Ensembl Acc Id: ENSRNOP00000099494   ⟸   ENSRNOT00000124426
Protein Domains
FERM   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62728-F1-model_v2 AlphaFold Q62728 1-1175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694769
Promoter ID:EPDNEW_R5293
Type:multiple initiation site
Name:Ptpn21_1
Description:protein tyrosine phosphatase, non-receptor type 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06122,721,565 - 122,721,625EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620216 AgrOrtholog
BioCyc Gene G2FUF-36535 BioCyc
Ensembl Genes ENSRNOG00000060568 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000079697 ENTREZGENE
Gene3D-CATH 1.20.80.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro Band_41_domain UniProtKB/Swiss-Prot
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot
  FERM_2 UniProtKB/Swiss-Prot
  FERM_central UniProtKB/Swiss-Prot
  FERM_CS UniProtKB/Swiss-Prot
  FERM_domain UniProtKB/Swiss-Prot
  FERM_N UniProtKB/Swiss-Prot
  FERM_PH-like_C UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  PTP_non-rcpt_14/21 UniProtKB/Swiss-Prot
  PTPase_domain UniProtKB/Swiss-Prot
  PTPN14/21_FERM_C UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:171070 UniProtKB/Swiss-Prot
NCBI Gene 171070 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21 UniProtKB/Swiss-Prot
Pfam FERM_C UniProtKB/Swiss-Prot
  FERM_M UniProtKB/Swiss-Prot
  FERM_N UniProtKB/Swiss-Prot
  Y_phosphatase UniProtKB/Swiss-Prot
PhenoGen Ptpn21 PhenoGen
PIRSF Tyr-Ptase_nr14 UniProtKB/Swiss-Prot
PRINTS BAND41 UniProtKB/Swiss-Prot
  PRTYPHPHTASE UniProtKB/Swiss-Prot
PROSITE FERM_1 UniProtKB/Swiss-Prot
  FERM_2 UniProtKB/Swiss-Prot
  FERM_3 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060568 RatGTEx
SMART B41 UniProtKB/Swiss-Prot
  FERM_C UniProtKB/Swiss-Prot
  PTPc UniProtKB/Swiss-Prot
  PTPc_motif UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47031 UniProtKB/Swiss-Prot
  SSF52799 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt A0A0G2JTB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIT8_RAT UniProtKB/TrEMBL
  A6JEE6_RAT UniProtKB/TrEMBL
  A6JEE7_RAT UniProtKB/TrEMBL
  A6JEE8_RAT UniProtKB/TrEMBL
  PTN21_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62732 ENTREZGENE
UniProt Secondary Q62732 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Ptpn21  protein tyrosine phosphatase, non-receptor type 21    protein tyrosine phosphatase 2E  Name updated 1299863 APPROVED
2004-09-10 Ptpn21  protein tyrosine phosphatase 2E  Ptp2E    Symbol and Name updated 1299863 APPROVED
2002-08-07 Ptp2E  protein tyrosine phosphatase 2E      Symbol and Name status set to provisional 70820 PROVISIONAL