RGD Reference Report - A neuronal protein tyrosine phosphatase induced by nerve growth factor. - Rat Genome Database

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A neuronal protein tyrosine phosphatase induced by nerve growth factor.

Authors: Sharma, E  Lombroso, PJ 
Citation: Sharma E and Lombroso PJ, J Biol Chem 1995 Jan 6;270(1):49-53.
RGD ID: 729713
Pubmed: PMID:7814416   (View Abstract at PubMed)

A new protein tyrosine phosphatase (PC12-PTP1) was identified in nerve growth factor (NGF)-treated PC12 cells. The mRNA level of PC12-PTP1 is increased 9-fold over the initial 8 h of NGF treatment and then decreases dramatically after 24 h of treatment. In rat brain, three transcripts corresponding to 1.5, 2.6, and 3.0 kilobases (kb) in size are detected by Northern blot analysis. Although the 1.5- and 2.6-kb transcripts are present in brain and other tissues, the 3-kb transcript is exclusively expressed in brain and the expression of this transcript alone increases following NGF treatment. PC12-PTP1 is a non-receptor protein tyrosine phosphatase (PTP) with a 50% sequence homology in the phosphatase domain with several other non-receptor PTPs. PC12-PTP1 fusion protein exhibits tyrosine phosphatase activity, and in vitro translation of the PC12-PTP1 transcript produces a major protein of 39 kDa. The data presented suggest that NGF regulates the expression of PC12-PTP1 during periods of neuronal growth and differentiation.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PtprrRatnervous system development  IEP  RGD 
PtprrRatneuron differentiation  IEP  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PtprrRatprotein tyrosine phosphatase activity  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptprr  (protein tyrosine phosphatase, receptor type, R)


Additional Information