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cDNA cloning of a cytosolic protein tyrosine phosphatase (RKPTP) from rat kidney.

Authors: Moriyama, T  Kawanishi, S  Inoue, T  Imai, E  Kaneko, T  Xia, C  Takenaka, M  Noguchi, T  Kamada, T  Ueda, N 
Citation: Moriyama T, etal., FEBS Lett 1994 Oct 24;353(3):305-8.
Pubmed: (View Article at PubMed) PMID:7957881

A rat cDNA encoding a non-receptor type phosphotyrosine phosphatase (PTPase; EC was identified. The 1608 bp cDNA contains a single open reading frame that predicts a 382 amino acid protein with M(r) 44,438. The predicted protein has no apparent signal or transmembrane sequences, suggesting that it is a cytosolic protein. The C-terminal region has a PTPase catalytic domain that has 40-50% nucleic acid homology to other known PTPases. The N-terminal region has little amino acid sequence homology to any other known sequences. The recombinant protein of the cloned cDNA expressed in Escherichia coli was shown to possess PTPase activity using myelin basic protein, tyrosine phosphorylated by p43v-abl tyrosine kinase, as a substrate.


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RGD Object Information
RGD ID: 633766
Created: 2003-08-29
Species: All species
Last Modified: 2004-05-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.