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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity  
[acetyl-CoA carboxylase]-phosphatase activity 
[glycogen-synthase-D] phosphatase activity 
[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity 
[isocitrate dehydrogenase (NADP+)] phosphatase activity 
[phosphorylase] phosphatase activity  
[pyruvate kinase]-phosphatase activity 
histone phosphatase activity +   
MAP kinase phosphatase activity +   
myosin-light-chain-phosphatase activity  
protein arginine phosphatase activity 
protein histidine phosphatase activity  
protein serine/threonine phosphatase activity +   
protein tyrosine phosphatase activity +   
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
protein tyrosine/serine/threonine phosphatase activity +   
protein tyrosine/threonine phosphatase activity  
transmembrane receptor protein phosphatase activity +   

Synonyms
Related Synonyms: PPT-phosphatase activity ;   PTP-phosphatase activity ;   PTPase activity ;   phosphoprotein phosphatase (phosphotyrosine) activity ;   phosphotyrosine histone phosphatase activity ;   phosphotyrosine phosphatase activity ;   phosphotyrosine protein phosphatase activity ;   phosphotyrosylprotein phosphatase activity ;   protein-tyrosine-phosphate phosphohydrolase activity ;   tyrosine O-phosphate phosphatase activity ;   tyrosylprotein phosphatase activity
Xrefs: EC:3.1.3.48 ;   MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN ;   RHEA:10684 ;   Reactome:R-HSA-8867658 "PTPN3 dephosphorylates MAPK12" ;   Reactome:R-HSA-9635461 "PtpA dephosphorylates GSK3A" ;   Reactome:R-HSA-9636439 "PtpA:Ub dephosphorylates p-Y133-VPS33B" ;   Reactome:R-HSA-9674816 "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS" ;   Reactome:R-HSA-9698408 "PTPRJ dephosphorylates active FLT3" ;   Reactome:R-HSA-9700200 "PTPRZ dephosphorylates ligand-bound ALK dimers" ;   Reactome:R-HSA-9701507 "PTPN6 dephosphorylates JAK3" ;   reactome:R-HSA-1169188 "SHP1 (PTPN6) dephosphorylates JAK2" ;   reactome:R-HSA-1169192 "PTP1B dephosphorylates GHR" ;   reactome:R-HSA-1169210 "PTP1B dephosphorylates JAK2" ;   reactome:R-HSA-1549564 "PPTN11 dephosphorylates SPRY2" ;   reactome:R-HSA-202214 "Dephosphorylation of Lck-pY505 by CD45" ;   reactome:R-HSA-203797 "ERKs are inactivated by dual-specific phosphatases (DUSPs)" ;   reactome:R-HSA-377643 "Dephosphorylation of inactive SRC by PTPB1" ;   reactome:R-HSA-389758 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases" ;   reactome:R-HSA-391868 "Dephosphorylation of NCAM1 bound pFyn" ;   reactome:R-HSA-445089 "Dephosphorylation of pL1 (Y1176)" ;   reactome:R-HSA-5683967 "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX" ;   reactome:R-HSA-6807008 "PTPRJ dephosphorylates MET" ;   reactome:R-HSA-6807027 "PTPN1 and PTPN2 dephosphorylate MET" ;   reactome:R-HSA-74733 "Insulin receptor de-phosphorylation" ;   reactome:R-HSA-74747 "Dephosphorylation of p-Y-IRS1,p-Y-IRS2" ;   reactome:R-HSA-74748 "De-phosphorylation of p-Y427-SHC1" ;   reactome:R-HSA-877308 "Dephosphorylation of JAKs by PTPs" ;   reactome:R-HSA-8849435 "PTPN1 dephosphorylates PTK6" ;   reactome:R-HSA-8852200 "Inactivation of LCK by PTPN22" ;   reactome:R-HSA-8855381 "PTPN22 dephosphorylates ZAP70" ;   reactome:R-HSA-8863804 "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248" ;   reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1148 (Y1172)" ;   reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021" ;   reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248" ;   reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15" ;   reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1" ;   reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB" ;   reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3" ;   reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2" ;   reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B" ;   reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1" ;   reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP"
Definition Sources: EC:3.1.3.48

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