Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:all-trans-4-oxoretinoic acid
go back to main search page
Accession:CHEBI:80656 term browser browse the term
Definition:A retinoid that consists of all-trans-retinoic acid bearing an oxo substituent at position 4 on the cyclohexenyl ring.
Synonyms:exact_synonym: 4-oxoretinoic acid
 related_synonym: 4-oxo-all-trans-retinoic acid;   4-oxo-atRA;   Formula=C20H26O3;   InChI=1S/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13+;   InChIKey=GGCUJPCCTQNTJF-FRCNGJHJSA-N;   SMILES=C\\C(\\C=C\\C1=C(C)C(=O)CCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
 xref: CAS:38030-57-8;   HMDB:HMDB0006285;   KEGG:C16678
 xref_mesh: MESH:C002202
 xref: PMID:2051220;   PMID:25492813;   PMID:2772923;   PMID:435468;   Reaxys:2878846


show annotations for term's descendants           Sort by:
all-trans-4-oxoretinoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein decreases expression ISO 4-oxoretinoic acid results in decreased expression of AIP mRNA CTD PMID:15982314 NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
G Anxa1 annexin A1 increases expression ISO 4-oxoretinoic acid results in increased expression of ANXA1 mRNA CTD PMID:15982314 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
G Apod apolipoprotein D increases expression ISO 4-oxoretinoic acid results in increased expression of APOD mRNA CTD PMID:15982314 NCBI chr16:31,115,010...31,133,626
Ensembl chr16:31,115,010...31,133,626 		JBrowse link
G Cbx3 chromobox 3 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CBX3 mRNA CTD PMID:15982314 NCBI chr 6:51,447,596...51,460,684
Ensembl chr 6:51,447,340...51,460,684 		JBrowse link
G Cdh1 cadherin 1 affects expression ISO 4-oxoretinoic acid affects the expression of CDH1 mRNA CTD PMID:17034753 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdkn1c cyclin dependent kinase inhibitor 1C increases expression ISO 4-oxoretinoic acid results in increased expression of CDKN1C mRNA CTD PMID:15982314 NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787 		JBrowse link
G Ckb creatine kinase, brain decreases expression ISO 4-oxoretinoic acid results in decreased expression of CKB mRNA CTD PMID:15982314 NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772 		JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression ISO 4-oxoretinoic acid results in increased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col4a2 collagen, type IV, alpha 2 increases expression ISO 4-oxoretinoic acid results in increased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr 8:11,362,878...11,499,287
Ensembl chr 8:11,362,805...11,499,287 		JBrowse link
G Col6a1 collagen, type VI, alpha 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of COL6A1 mRNA CTD PMID:15982314 NCBI chr10:76,544,626...76,561,869
Ensembl chr10:76,544,626...76,562,002 		JBrowse link
G Col8a2 collagen, type VIII, alpha 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of COL8A2 mRNA CTD PMID:15982314 NCBI chr 4:126,180,613...126,208,123
Ensembl chr 4:126,180,586...126,208,123 		JBrowse link
G Crabp2 cellular retinoic acid binding protein II increases expression ISO 4-oxoretinoic acid results in increased expression of CRABP2 mRNA CTD PMID:17034753 NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CXCL1 mRNA CTD PMID:15982314 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CXCL1 mRNA CTD PMID:15982314 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases chemical synthesis ISO CYP1A1 protein results in increased chemical synthesis of 4-oxoretinoic acid CTD PMID:10874126 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression
multiple interactions
increases metabolic processing
increases chemical synthesis		 ISO 4-oxoretinoic acid results in increased expression of CYP26A1 mRNA
[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [R 115866 results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]
CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid; CYP26A1 protein results in increased metabolism of 4-oxoretinoic acid
CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid; CYP26A1 protein results in increased chemical synthesis of 4-oxoretinoic acid		 CTD PMID:12091498 PMID:17460545 PMID:25492813 NCBI chr19:37,686,186...37,689,984
Ensembl chr19:37,686,246...37,689,984 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CYP27A1 mRNA CTD PMID:15982314 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of 4-oxoretinoic acid CTD PMID:10874126 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases chemical synthesis ISO CYP2C9 protein results in increased chemical synthesis of 4-oxoretinoic acid CTD PMID:10874126 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CYP3A7 mRNA CTD PMID:15982314 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Dsc1 desmocollin 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of DSC1 mRNA CTD PMID:15982314 NCBI chr18:20,216,528...20,247,830
Ensembl chr18:20,217,241...20,247,928 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO 4-oxoretinoic acid results in increased expression of DUSP10 mRNA CTD PMID:15982314 NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833 		JBrowse link
G Dusp11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) decreases expression ISO 4-oxoretinoic acid results in decreased expression of DUSP11 mRNA CTD PMID:15982314 NCBI chr 6:85,919,250...85,938,950
Ensembl chr 6:85,919,250...85,938,649 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of E2F1 mRNA CTD PMID:15982314 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO 4-oxoretinoic acid results in decreased expression of EGFR mRNA CTD PMID:15982314 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of EIF4EBP2 mRNA CTD PMID:15982314 NCBI chr10:61,268,276...61,288,448
Ensembl chr10:61,264,270...61,288,440 		JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO 4-oxoretinoic acid results in increased expression of EMP1 mRNA CTD PMID:15982314 NCBI chr 6:135,339,548...135,360,171
Ensembl chr 6:135,339,543...135,360,171 		JBrowse link
G Fabp5 fatty acid binding protein 5, epidermal decreases expression ISO 4-oxoretinoic acid results in decreased expression of FABP5 mRNA CTD PMID:15982314 NCBI chr 3:10,077,645...10,081,670
Ensembl chr 3:10,077,608...10,081,667 		JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C increases expression ISO 4-oxoretinoic acid results in increased expression of FAM3C mRNA CTD PMID:15982314 NCBI chr 6:22,306,519...22,356,080
Ensembl chr 6:22,306,519...22,356,242 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO 4-oxoretinoic acid results in decreased expression of FAS mRNA CTD PMID:17034753 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasn fatty acid synthase increases expression ISO 4-oxoretinoic acid results in increased expression of FASN mRNA CTD PMID:15982314 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fastk Fas-activated serine/threonine kinase decreases expression ISO 4-oxoretinoic acid results in decreased expression of FASTK mRNA CTD PMID:15982314 NCBI chr 5:24,646,036...24,650,280
Ensembl chr 5:24,643,438...24,650,285 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of FGF1 mRNA CTD PMID:15982314 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525 		JBrowse link
G Fkbp8 FK506 binding protein 8 increases expression ISO 4-oxoretinoic acid results in increased expression of FKBP8 mRNA CTD PMID:15982314 NCBI chr 8:70,980,371...70,987,978
Ensembl chr 8:70,980,374...70,987,978 		JBrowse link
G Flg filaggrin decreases expression ISO 4-oxoretinoic acid results in decreased expression of FLG mRNA CTD PMID:15982314 NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993 		JBrowse link
G Foxa1 forkhead box A1 increases expression ISO 4-oxoretinoic acid results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr12:57,585,750...57,594,815
Ensembl chr12:57,587,414...57,593,702 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases expression ISO 4-oxoretinoic acid results in increased expression of G6PD mRNA CTD PMID:15982314 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO 4-oxoretinoic acid results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635 		JBrowse link
G Gba1 glucosylceramidase beta 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of GBA1 mRNA CTD PMID:15982314 NCBI chr 3:89,110,235...89,119,944
Ensembl chr 3:89,110,235...89,116,273 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO 4-oxoretinoic acid results in increased expression of GDF15 mRNA CTD PMID:15982314 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106 		JBrowse link
G Gdf2 growth differentiation factor 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of GDF2 mRNA CTD PMID:15982314 NCBI chr14:33,662,996...33,669,155
Ensembl chr14:33,662,996...33,669,155 		JBrowse link
G Glul glutamate-ammonia ligase increases expression ISO 4-oxoretinoic acid results in increased expression of GLUL mRNA CTD PMID:15982314 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469 		JBrowse link
G Grb7 growth factor receptor bound protein 7 decreases expression ISO 4-oxoretinoic acid results in decreased expression of GRB7 mRNA CTD PMID:15982314 NCBI chr11:98,337,660...98,346,199
Ensembl chr11:98,337,220...98,346,199 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of GSTM1 mRNA CTD PMID:15982314 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO 4-oxoretinoic acid results in increased expression of HBEGF mRNA CTD PMID:15982314 NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO 4-oxoretinoic acid results in increased expression of IGF1 mRNA CTD PMID:15982314 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igf2 insulin-like growth factor 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of IGF2 mRNA CTD PMID:15982314 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO 4-oxoretinoic acid results in increased expression of IGFBP3 mRNA CTD PMID:15982314 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923 		JBrowse link
G Il10ra interleukin 10 receptor, alpha decreases expression ISO 4-oxoretinoic acid results in decreased expression of IL10RA mRNA CTD PMID:15982314 NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO 4-oxoretinoic acid results in increased expression of IL1B mRNA CTD PMID:15982314 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il24 interleukin 24 decreases expression ISO 4-oxoretinoic acid results in decreased expression of IL24 mRNA CTD PMID:15982314 NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191 		JBrowse link
G Itga4 integrin alpha 4 increases expression ISO 4-oxoretinoic acid results in increased expression of ITGA4 mRNA CTD PMID:15982314 NCBI chr 2:79,084,767...79,163,458
Ensembl chr 2:79,085,770...79,163,467 		JBrowse link
G Ivl involucrin increases expression ISO 4-oxoretinoic acid results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 3:92,478,206...92,481,097
Ensembl chr 3:92,478,209...92,481,042 		JBrowse link
G Krt1 keratin 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT1 mRNA CTD PMID:15982314 NCBI chr15:101,753,861...101,759,221
Ensembl chr15:101,753,861...101,759,229 		JBrowse link
G Krt10 keratin 10 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT10 mRNA CTD PMID:15982314 NCBI chr11:99,276,080...99,288,631
Ensembl chr11:99,276,080...99,280,190 		JBrowse link
G Krt14 keratin 14 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT14 mRNA CTD PMID:15982314 NCBI chr11:100,093,988...100,098,336
Ensembl chr11:100,093,988...100,098,374 		JBrowse link
G Krt15 keratin 15 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT15 mRNA CTD PMID:15982314 NCBI chr11:100,022,585...100,026,775
Ensembl chr11:100,022,584...100,026,754 		JBrowse link
G Krt17 keratin 17 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT17 mRNA CTD PMID:15982314 NCBI chr11:100,147,041...100,151,855
Ensembl chr11:100,147,043...100,151,855 		JBrowse link
G Krt18 keratin 18 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462 		JBrowse link
G Krt19 keratin 19 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT19 mRNA; 4-oxoretinoic acid results in increased expression of KRT19 protein CTD PMID:15982314 PMID:17034753 NCBI chr11:100,031,636...100,036,752
Ensembl chr11:100,031,636...100,039,491 		JBrowse link
G Krt5 keratin 5 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT5 mRNA CTD PMID:15982314 NCBI chr15:101,615,504...101,621,340
Ensembl chr15:101,615,505...101,621,333 		JBrowse link
G Krt6a keratin 6A decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT6A mRNA CTD PMID:15982314 NCBI chr15:101,598,363...101,602,746
Ensembl chr15:101,598,345...101,602,742 		JBrowse link
G Krt7 keratin 7 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT7 mRNA; 4-oxoretinoic acid results in increased expression of KRT7 protein CTD PMID:15982314 PMID:17034753 NCBI chr15:101,310,284...101,325,687
Ensembl chr15:101,308,924...101,328,194 		JBrowse link
G Krt75 keratin 75 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT75 mRNA CTD PMID:15982314 NCBI chr15:101,471,778...101,482,339
Ensembl chr15:101,471,780...101,482,339 		JBrowse link
G Krt8 keratin 8 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917 		JBrowse link
G Lama2 laminin, alpha 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of LAMA2 mRNA CTD PMID:15982314 NCBI chr10:26,857,281...27,493,021
Ensembl chr10:26,856,032...27,495,754 		JBrowse link
G Lama3 laminin, alpha 3 decreases expression ISO 4-oxoretinoic acid results in decreased expression of LAMA3 mRNA CTD PMID:15982314 NCBI chr18:12,466,806...12,716,070
Ensembl chr18:12,466,876...12,716,070 		JBrowse link
G Lamc3 laminin gamma 3 increases expression ISO 4-oxoretinoic acid results in increased expression of LAMC3 mRNA CTD PMID:15982314 NCBI chr 2:31,777,293...31,839,095
Ensembl chr 2:31,777,303...31,836,551 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO 4-oxoretinoic acid results in increased expression of LCN2 mRNA CTD PMID:15982314 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Meis1 Meis homeobox 1 increases expression ISO 4-oxoretinoic acid results in increased expression of MEIS1 mRNA CTD PMID:17034753 NCBI chr11:18,830,428...18,968,992
Ensembl chr11:18,829,817...18,968,985 		JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO 4-oxoretinoic acid results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 2:115,691,745...115,897,925
Ensembl chr 2:115,693,545...115,896,320 		JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO 4-oxoretinoic acid results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr11:101,768,336...101,785,309
Ensembl chr11:101,768,336...101,785,200 		JBrowse link
G Mfap2 microfibrillar-associated protein 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of MFAP2 mRNA CTD PMID:15982314 NCBI chr 4:140,737,735...140,743,284
Ensembl chr 4:140,737,729...140,743,295 		JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO 4-oxoretinoic acid results in decreased expression of MMP10 mRNA CTD PMID:15982314 NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric increases expression ISO 4-oxoretinoic acid results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated gene 9 increases expression ISO 4-oxoretinoic acid results in increased expression of NEDD9 mRNA CTD PMID:15982314 NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838 		JBrowse link
G Nefl neurofilament, light polypeptide decreases expression ISO 4-oxoretinoic acid results in decreased expression of NEFL mRNA CTD PMID:15982314 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of ODC1 mRNA CTD PMID:15982314 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression ISO 4-oxoretinoic acid results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128 		JBrowse link
G Pir pirin increases expression ISO 4-oxoretinoic acid results in increased expression of PIR mRNA CTD PMID:15982314 NCBI chr  X:163,052,427...163,156,009
Ensembl chr  X:163,052,367...163,156,007 		JBrowse link
G Plat plasminogen activator, tissue increases expression ISO 4-oxoretinoic acid results in increased expression of PLAT mRNA CTD PMID:15982314 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of PTGS1 mRNA CTD PMID:15982314 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of PTGS2 mRNA CTD PMID:15982314 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rara retinoic acid receptor, alpha increases expression
increases activity		 ISO 4-oxoretinoic acid results in increased expression of RARA mRNA
4-oxoretinoic acid results in increased activity of RARA protein		 CTD PMID:17034753 PMID:25492813 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Rarb retinoic acid receptor, beta increases activity
increases expression		 ISO 4-oxoretinoic acid results in increased activity of RARB protein
4-oxoretinoic acid results in increased expression of RARB mRNA		 CTD PMID:17034753 PMID:25492813 NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924 		JBrowse link
G Rarg retinoic acid receptor, gamma increases activity
multiple interactions		 ISO 4-oxoretinoic acid results in increased activity of RARG protein
4-oxoretinoic acid results in increased activity of [RARG protein binds to RXRA protein]		 CTD PMID:25492813 PMID:30639747 NCBI chr15:102,143,373...102,165,891
Ensembl chr15:102,143,373...102,165,952 		JBrowse link
G Rarres1 retinoic acid receptor responder (tazarotene induced) 1 increases expression ISO 4-oxoretinoic acid results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 3:67,386,219...67,422,856
Ensembl chr 3:67,386,305...67,422,856 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO 4-oxoretinoic acid results in decreased expression of RHOA mRNA CTD PMID:15982314 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rhob ras homolog family member B decreases expression ISO 4-oxoretinoic acid results in decreased expression of RHOB mRNA CTD PMID:15982314 NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009 		JBrowse link
G Rnf5 ring finger protein 5 decreases expression ISO 4-oxoretinoic acid results in decreased expression of RNF5 mRNA CTD PMID:15982314 NCBI chr17:34,820,073...34,822,535
Ensembl chr17:34,820,065...34,822,664 		JBrowse link
G Rps13 ribosomal protein S13 increases expression ISO 4-oxoretinoic acid results in increased expression of RPS13 mRNA CTD PMID:15982314 NCBI chr 7:115,930,742...115,933,425
Ensembl chr 7:115,930,740...115,933,430 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO 4-oxoretinoic acid results in increased activity of [RARG protein binds to RXRA protein] CTD PMID:30639747 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G S100a1 S100 calcium binding protein A1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of S100A1 mRNA CTD PMID:15982314 NCBI chr 3:90,418,341...90,421,637
Ensembl chr 3:90,418,341...90,421,699 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) increases expression ISO 4-oxoretinoic acid results in increased expression of S100A8 mRNA CTD PMID:15982314 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression ISO 4-oxoretinoic acid results in increased expression of S100A9 mRNA CTD PMID:15982314 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028 		JBrowse link
G Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO 4-oxoretinoic acid results in increased expression of SERPINA3 mRNA CTD PMID:15982314 NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804 		JBrowse link
G Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SERPINB2 mRNA CTD PMID:15982314 NCBI chr 1:107,439,153...107,453,330
Ensembl chr 1:107,439,153...107,463,208 		JBrowse link
G Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SERPINB9 mRNA CTD PMID:15982314 NCBI chr13:33,181,044...33,201,938
Ensembl chr13:33,187,233...33,201,940 		JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SLC16A1 mRNA CTD PMID:15982314 NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SOCS1 mRNA CTD PMID:15982314 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression ISO 4-oxoretinoic acid results in increased expression of SOCS2 mRNA CTD PMID:15982314 NCBI chr10:95,219,765...95,253,176
Ensembl chr10:95,221,224...95,253,042 		JBrowse link
G Sprr1b small proline-rich protein 1B decreases expression ISO 4-oxoretinoic acid results in decreased expression of SPRR1B mRNA CTD PMID:15982314 NCBI chr 3:92,344,115...92,346,124
Ensembl chr 3:92,344,116...92,346,096 		JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SULT2A1 mRNA CTD PMID:15982314 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334 		JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 increases expression ISO 4-oxoretinoic acid results in increased expression of TGFB1I1 mRNA CTD PMID:15982314 NCBI chr 7:127,845,963...127,852,884
Ensembl chr 7:127,845,984...127,854,871 		JBrowse link
G Tgm1 transglutaminase 1, K polypeptide decreases expression ISO 4-oxoretinoic acid results in decreased expression of TGM1 mRNA CTD PMID:15982314 NCBI chr14:55,937,466...55,951,378
Ensembl chr14:55,937,466...55,951,383 		JBrowse link
G Tgm2 transglutaminase 2, C polypeptide increases expression ISO 4-oxoretinoic acid results in increased expression of TGM2 mRNA CTD PMID:17034753 NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356 		JBrowse link
G Thbs1 thrombospondin 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of THBS1 mRNA CTD PMID:15982314 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Tmsb4x thymosin, beta 4, X chromosome increases expression ISO 4-oxoretinoic acid results in increased expression of TMSB4X mRNA CTD PMID:15982314 NCBI chr  X:165,990,089...165,996,475
Ensembl chr  X:165,990,089...165,992,311 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO 4-oxoretinoic acid results in decreased expression of VEGFC mRNA CTD PMID:15982314 NCBI chr 8:54,530,567...54,639,489
Ensembl chr 8:54,530,641...54,640,131 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      chemical role 21425
        antioxidant 16416
          all-trans-retinoic acid 10184
            all-trans-4-oxoretinoic acid 110
              1-O-(4-oxoretinoyl)-beta-D-glucuronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    main group molecular entity 22120
                      s-block molecular entity 21721
                        hydrogen molecular entity 21639
                          hydrides 20777
                            organic hydride 20336
                              organic fundamental parent 20336
                                hydrocarbon 19917
                                  terpene 14787
                                    terpenoid 14480
                                      diterpenoid 13724
                                        retinoid 10520
                                          vitamin A 10222
                                            all-trans-retinoic acid 10184
                                              all-trans-4-oxoretinoic acid 110
                                                1-O-(4-oxoretinoyl)-beta-D-glucuronic acid 0
paths to the root