Lama2 (laminin, alpha 2) - Rat Genome Database

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Gene: Lama2 (laminin, alpha 2) Mus musculus
Analyze
Symbol: Lama2
Name: laminin, alpha 2
RGD ID: 1318919
MGI Page MGI
Description: Predicted to be an extracellular matrix structural constituent. Acts upstream of or within axon guidance and positive regulation of cholinergic synaptic transmission. Located in basement membrane and sarcolemma. Is active in neuromuscular junction and synaptic cleft. Is expressed in several structures, including alimentary system; extracellular matrix; metanephros; musculature; and nervous system. Used to study congenital merosin-deficient muscular dystrophy 1A. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5830440B04; dy; dystrophia muscularis; KIAA4087; laminin M chain; laminin subunit alpha-2; laminin-12 subunit alpha; laminin-2 subunit alpha; laminin-4 subunit alpha; me; mer; merosin; merosin heavy chain; mKIAA4087
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391026,857,281 - 27,493,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1026,856,032 - 27,495,754 (-)EnsemblGRCm39 Ensembl
GRCm381026,981,285 - 27,617,191 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1026,980,036 - 27,619,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv371026,701,091 - 27,336,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361026,670,819 - 27,306,267 (-)NCBIMGSCv36mm8
Celera1027,907,208 - 28,541,586 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1014.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP)
amphetamine  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
calcitriol  (ISO)
cantharidin  (EXP)
captan  (EXP)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
Cuprizon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
diquat  (EXP)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
folic acid  (EXP)
fonofos  (ISO)
inulin  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenytoin  (ISO)
pioglitazone  (EXP)
potassium dichromate  (EXP)
progesterone  (EXP)
propanal  (ISO)
Ptaquiloside  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
sotorasib  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
topotecan  (ISO)
trametinib  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axon radial sorting  (IAGP)
abnormal axonal transport  (IAGP)
abnormal basal lamina morphology  (IAGP)
abnormal basement membrane morphology  (IAGP)
abnormal bony labyrinth  (IAGP)
abnormal cochlear hair cell morphology  (IAGP)
abnormal cochlear nerve morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal gait  (IAGP)
abnormal galactolipid level  (IAGP)
abnormal inner ear vestibule morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal myelination  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal organ of Corti supporting cell morphology  (IAGP)
abnormal physical strength  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal reflex  (IAGP)
abnormal rostral migratory stream morphology  (IAGP)
abnormal sarcolemma morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal sexual interaction  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal testis morphology  (IAGP)
abnormal thymus corticomedullary boundary morphology  (IAGP)
abnormal thymus physiology  (IAGP)
absent cochlear hair cells  (IAGP)
absent vestibular hair cells  (IAGP)
ataxia  (IAGP)
cachexia  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
cochlear degeneration  (IAGP)
decreased aggression  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain weight  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased grip strength  (IAGP)
decreased IgM level  (IAGP)
decreased locomotor activity  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased Schwann cell number  (IAGP)
decreased skeletal muscle fiber number  (IAGP)
decreased spinal cord weight  (IAGP)
decreased T cell number  (IAGP)
decreased testis weight  (IAGP)
demyelination  (IAGP)
dystrophic muscle  (IAGP)
enhanced long-term potentiation  (IAGP)
enhanced skeletal muscle regeneration  (IAGP)
extended life span  (IAGP)
hindlimb paralysis  (IAGP)
hindlimb paresis  (IAGP)
impaired skeletal muscle regeneration  (IAGP)
increased body weight  (IAGP)
increased cholesterol level  (IAGP)
increased circulating prolactin level  (IAGP)
increased cranium width  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased skeletal muscle mass  (IAGP)
increased variability of skeletal muscle fiber size  (IAGP)
joint contracture  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
limb grasping  (IAGP)
muscle degeneration  (IAGP)
muscle spasm  (IAGP)
muscle weakness  (IAGP)
myopathy  (IAGP)
myositis  (IAGP)
opisthotonus  (IAGP)
paresis  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
progressive muscle weakness  (IAGP)
reduced long-term depression  (IAGP)
scoliosis  (IAGP)
skeletal muscle endomysial fibrosis  (IAGP)
skeletal muscle fiber necrosis  (IAGP)
skeletal muscle interstitial fibrosis  (IAGP)
stria vascularis degeneration  (IAGP)
tachypnea  (IAGP)
thymus cortex hypoplasia  (IAGP)
tremors  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy. Helbling-Leclerc A, etal., Nat Genet. 1995 Oct;11(2):216-8.
2. Correction of a splicing defect in a mouse model of congenital muscular dystrophy type 1A using a homology-directed-repair-independent mechanism. Kemaladewi DU, etal., Nat Med. 2017 Aug;23(8):984-989. doi: 10.1038/nm.4367. Epub 2017 Jul 17.
3. Expression of laminin-2 by normal and neoplastic rat C cells during the development of medullary thyroid carcinoma. Lekmine F, etal., Virchows Arch. 1999 Apr;434(4):325-32.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Expression of laminin alpha2 chain during normal and pathological growth of myocardium in rat and human. Oliviero P, etal., Cardiovasc Res. 2000 May;46(2):346-55.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. When do myopia genes have their effect? Comparison of genetic risks between children and adults. Tideman JW, etal., Genet Epidemiol. 2016 Dec;40(8):756-766. doi: 10.1002/gepi.21999. Epub 2016 Sep 9.
Additional References at PubMed
PMID:61889   PMID:73571   PMID:196056   PMID:202877   PMID:471185   PMID:563524   PMID:591440   PMID:630405   PMID:647395   PMID:894325   PMID:1139295   PMID:1161034  
PMID:1185240   PMID:1265049   PMID:1290587   PMID:1301630   PMID:1577403   PMID:1634888   PMID:1678389   PMID:1757468   PMID:1894637   PMID:2014247   PMID:2119632   PMID:2183046  
PMID:2185464   PMID:2203673   PMID:2478549   PMID:2989438   PMID:3109910   PMID:3402356   PMID:3440862   PMID:3794389   PMID:3954056   PMID:4120487   PMID:5434356   PMID:6447833  
PMID:6490723   PMID:6831246   PMID:7225891   PMID:7481760   PMID:7510707   PMID:7588220   PMID:7650451   PMID:7655459   PMID:7795883   PMID:7803849   PMID:7874173   PMID:8188645  
PMID:8202529   PMID:8225042   PMID:8276772   PMID:8294519   PMID:8345183   PMID:8540630   PMID:8568931   PMID:8568939   PMID:8601607   PMID:8613743   PMID:8663504   PMID:8684619  
PMID:8719886   PMID:8872465   PMID:8950511   PMID:9004048   PMID:9034910   PMID:9066911   PMID:9125222   PMID:9132144   PMID:9151674   PMID:9175728   PMID:9185545   PMID:9188790  
PMID:9201115   PMID:9264260   PMID:9326364   PMID:9334342   PMID:9349541   PMID:9361014   PMID:9389447   PMID:9390664   PMID:9396756   PMID:9397579   PMID:9415429   PMID:9427295  
PMID:9524190   PMID:9549731   PMID:9555049   PMID:9573353   PMID:9633519   PMID:9710454   PMID:9728058   PMID:9733105   PMID:9742403   PMID:9833687   PMID:9852162   PMID:9882526  
PMID:10022829   PMID:10024132   PMID:10102687   PMID:10349636   PMID:10364433   PMID:10381357   PMID:10461905   PMID:10505103   PMID:10574769   PMID:10575223   PMID:10601345   PMID:10616210  
PMID:10619025   PMID:10625553   PMID:10679965   PMID:10702665   PMID:10753064   PMID:10757814   PMID:10772822   PMID:10792494   PMID:10838257   PMID:11042159   PMID:11076861   PMID:11115849  
PMID:11217851   PMID:11369940   PMID:11381080   PMID:11460266   PMID:11564885   PMID:11565031   PMID:11595512   PMID:11741881   PMID:11784026   PMID:11802174   PMID:11829758   PMID:11969289  
PMID:12044978   PMID:12051813   PMID:12126936   PMID:12383920   PMID:12466851   PMID:12477932   PMID:12609502   PMID:12609503   PMID:12736195   PMID:12840158   PMID:12843252   PMID:12900932  
PMID:12921739   PMID:14581460   PMID:14638863   PMID:14681233   PMID:14729866   PMID:14730302   PMID:14734655   PMID:15056720   PMID:15184359   PMID:15213105   PMID:15578095   PMID:15681832  
PMID:15699217   PMID:15739233   PMID:15757977   PMID:15817132   PMID:15817462   PMID:15823249   PMID:15859351   PMID:15895400   PMID:15923403   PMID:16073433   PMID:16103356   PMID:16127160  
PMID:16135075   PMID:16141072   PMID:16141073   PMID:16198565   PMID:16221851   PMID:16368874   PMID:16429580   PMID:16452166   PMID:16498405   PMID:16504180   PMID:16565216   PMID:16589799  
PMID:16684813   PMID:16750824   PMID:16782317   PMID:16893907   PMID:16916601   PMID:17344408   PMID:17366632   PMID:17389231   PMID:17459142   PMID:17475492   PMID:17591965   PMID:17601529  
PMID:17948866   PMID:17963748   PMID:18345011   PMID:18430779   PMID:18434328   PMID:18590826   PMID:18611855   PMID:18757743   PMID:18817539   PMID:19086066   PMID:19240213   PMID:19295126  
PMID:19321787   PMID:19373938   PMID:19535581   PMID:19688041   PMID:19692349   PMID:19776266   PMID:19793892   PMID:19800000   PMID:20227383   PMID:20544910   PMID:20657839   PMID:20670915  
PMID:20876525   PMID:20976766   PMID:21084425   PMID:21285247   PMID:21441569   PMID:21445359   PMID:21505075   PMID:21524702   PMID:21652631   PMID:21674808   PMID:21750040   PMID:21850221  
PMID:21873635   PMID:21900571   PMID:21920942   PMID:21983115   PMID:21989910   PMID:22159717   PMID:22270369   PMID:22322301   PMID:22427904   PMID:22613833   PMID:22654118   PMID:22696295  
PMID:22706957   PMID:22759265   PMID:22767514   PMID:22906538   PMID:22911573   PMID:22925892   PMID:22943509   PMID:23274062   PMID:23472759   PMID:23762378   PMID:23773998   PMID:23948589  
PMID:24006456   PMID:24009313   PMID:24191021   PMID:24312627   PMID:24344238   PMID:24393714   PMID:24631023   PMID:24680793   PMID:24687281   PMID:24722207   PMID:24915008   PMID:25071564  
PMID:25392494   PMID:25575511   PMID:25695270   PMID:26355035   PMID:26440893   PMID:26465331   PMID:26555376   PMID:26731667   PMID:26733533   PMID:26794322   PMID:26999812   PMID:27068110  
PMID:27138650   PMID:27234308   PMID:27363389   PMID:27435623   PMID:28071719   PMID:28082118   PMID:28218617   PMID:28281577   PMID:28334989   PMID:28636612   PMID:28659438   PMID:28771630  
PMID:28880149   PMID:29335257   PMID:29544677   PMID:29566247   PMID:29763467   PMID:30139390   PMID:30389963   PMID:31308722   PMID:31348492   PMID:31371375   PMID:31586140   PMID:31882770  
PMID:32017711   PMID:32072250   PMID:32325033   PMID:32472139   PMID:32498713   PMID:33805532   PMID:34504132   PMID:35245678   PMID:36098369   PMID:36350252   PMID:36440275   PMID:36514952  
PMID:36709857   PMID:36878377  


Genomics

Comparative Map Data
Lama2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391026,857,281 - 27,493,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1026,856,032 - 27,495,754 (-)EnsemblGRCm39 Ensembl
GRCm381026,981,285 - 27,617,191 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1026,980,036 - 27,619,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv371026,701,091 - 27,336,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361026,670,819 - 27,306,267 (-)NCBIMGSCv36mm8
Celera1027,907,208 - 28,541,586 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1014.23NCBI
LAMA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386128,883,138 - 129,516,566 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6128,883,138 - 129,516,566 (+)EnsemblGRCh38hg38GRCh38
GRCh376129,204,283 - 129,837,711 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366129,245,979 - 129,879,404 (+)NCBINCBI36Build 36hg18NCBI36
Build 346129,246,034 - 129,879,401NCBI
Celera6129,950,556 - 130,583,793 (+)NCBICelera
Cytogenetic Map6q22.33NCBI
HuRef6126,785,527 - 127,418,362 (+)NCBIHuRef
CHM1_16129,468,357 - 130,101,369 (+)NCBICHM1_1
T2T-CHM13v2.06130,076,331 - 130,710,229 (+)NCBIT2T-CHM13v2.0
Lama2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8119,492,126 - 20,140,056 (+)NCBIGRCr8
mRatBN7.2117,672,675 - 18,320,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl117,672,536 - 18,320,530 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0118,491,264 - 19,143,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl118,491,384 - 19,143,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0120,002,787 - 20,647,256 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4118,203,466 - 18,885,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1118,324,930 - 18,885,310 (+)NCBI
Celera116,078,601 - 16,724,118 (+)NCBICelera
Cytogenetic Map1p12NCBI
Lama2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554369,830,030 - 10,399,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554369,829,777 - 10,400,101 (+)NCBIChiLan1.0ChiLan1.0
LAMA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25148,876,669 - 149,513,805 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16146,784,037 - 147,421,936 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06126,672,013 - 127,307,870 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16130,781,676 - 131,415,549 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6130,781,781 - 131,415,337 (+)Ensemblpanpan1.1panPan2
LAMA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,645,461 - 68,096,506 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,611,122 - 68,095,914 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,254,521 - 68,844,637 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0167,721,690 - 68,305,337 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl167,721,701 - 68,304,715 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1167,644,723 - 68,228,165 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,427,961 - 68,011,313 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0168,070,825 - 68,654,877 (+)NCBIUU_Cfam_GSD_1.0
Lama2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946117,593,991 - 118,159,491 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936639259,889 - 825,065 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936639259,662 - 825,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl133,866,850 - 34,359,698 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1133,765,412 - 34,359,741 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2137,284,919 - 37,545,503 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAMA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11344,074,128 - 44,688,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1344,073,525 - 44,531,889 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604016,239,880 - 16,874,460 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lama2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247533,336,227 - 3,793,940 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247533,194,678 - 3,794,145 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lama2
23117 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSMUST00000092639
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
1301796Mop2_mmorphine preference 2 (mouse)Not determined10928911929028424Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1558857Igan1_mIgA nephropathy 1 (mouse)Not determined101771831329704155Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
1301659Arrd2_mage-related retinal degeneration 2 (mouse)Not determined102028318526890391Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102237589951076096Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
4142209Psrs1_mpsoriasis susceptibility 1 (mouse)Not determined102689026446720483Mouse

Markers in Region
03.MMHAP11FLA3.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381027,469,900 - 27,470,099UniSTSGRCm38
MGSCv371027,189,706 - 27,189,905UniSTSGRCm37
Celera1028,394,656 - 28,394,855UniSTS
Cytogenetic Map10A4-B1UniSTS
Whitehead_YAC10 UniSTS
D10Mit126.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381027,014,424 - 27,014,545UniSTSGRCm38
MGSCv371026,734,230 - 26,734,351UniSTSGRCm37
Celera1027,943,492 - 27,943,613UniSTS
Cytogenetic Map10A4-B1UniSTS
cM Map1021.0UniSTS
cM Map10 UniSTS
Whitehead Genetic1016.4UniSTS
MT905  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381027,014,268 - 27,014,395UniSTSGRCm38
MGSCv371026,734,074 - 26,734,201UniSTSGRCm37
Celera1027,943,340 - 27,943,463UniSTS
Cytogenetic Map10A4-B1UniSTS
Cytogenetic Map10C1-C3UniSTS
cM Map1021.0UniSTS
Whitehead Genetic1016.4UniSTS
Lama2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A4-B1UniSTS
cM Map1020.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006512566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC101709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC152982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC153800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC155942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC167232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC171406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB637328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD350015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S75315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000092639   ⟹   ENSMUSP00000090304
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1026,857,281 - 27,492,839 (-)Ensembl
GRCm38.p6 Ensembl1026,981,285 - 27,616,843 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185839
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1027,140,404 - 27,492,938 (-)Ensembl
GRCm38.p6 Ensembl1027,264,408 - 27,616,942 (-)Ensembl
RefSeq Acc Id: ENSMUST00000186279
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1026,856,032 - 26,864,510 (-)Ensembl
GRCm38.p6 Ensembl1026,980,036 - 26,988,514 (-)Ensembl
RefSeq Acc Id: ENSMUST00000186965
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1027,220,247 - 27,492,862 (-)Ensembl
GRCm38.p6 Ensembl1027,344,251 - 27,616,866 (-)Ensembl
RefSeq Acc Id: ENSMUST00000187535
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1027,351,312 - 27,492,862 (-)Ensembl
GRCm38.p6 Ensembl1027,475,316 - 27,616,866 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188963
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1027,298,388 - 27,495,754 (-)Ensembl
GRCm38.p6 Ensembl1027,422,392 - 27,619,758 (-)Ensembl
RefSeq Acc Id: ENSMUST00000189575   ⟹   ENSMUSP00000140716
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1027,063,544 - 27,492,792 (-)Ensembl
GRCm38.p6 Ensembl1027,187,548 - 27,616,796 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219763   ⟹   ENSMUSP00000151741
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1026,857,491 - 26,932,641 (-)Ensembl
GRCm38.p6 Ensembl1026,981,495 - 27,056,645 (-)Ensembl
RefSeq Acc Id: ENSMUST00000239098   ⟹   ENSMUSP00000158963
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1027,080,797 - 27,088,250 (-)Ensembl
GRCm38.p6 Ensembl1027,204,801 - 27,212,254 (-)Ensembl
RefSeq Acc Id: NM_008481   ⟹   NP_032507
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391026,857,281 - 27,492,862 (-)NCBI
GRCm381026,981,285 - 27,616,942 (-)NCBI
MGSCv371026,701,091 - 27,336,748 (-)RGD
Celera1027,907,208 - 28,541,586 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512566   ⟹   XP_006512629
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391026,963,991 - 27,493,021 (-)NCBI
GRCm381027,087,951 - 27,617,191 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011243134   ⟹   XP_011241436
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391026,857,281 - 27,493,021 (-)NCBI
GRCm381026,981,285 - 27,617,025 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011243135   ⟹   XP_011241437
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391026,857,281 - 27,493,021 (-)NCBI
GRCm381026,981,285 - 27,617,025 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313815   ⟹   XP_017169304
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391026,857,281 - 27,493,021 (-)NCBI
GRCm381026,981,285 - 27,617,025 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032507   ⟸   NM_008481
- Peptide Label: precursor
- UniProtKB: Q05003 (UniProtKB/Swiss-Prot),   F8VQ43 (UniProtKB/Swiss-Prot),   Q64061 (UniProtKB/Swiss-Prot),   Q60675 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006512629   ⟸   XM_006512566
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011241436   ⟸   XM_011243134
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011241437   ⟸   XM_011243135
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017169304   ⟸   XM_017313815
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000090304   ⟸   ENSMUST00000092639
RefSeq Acc Id: ENSMUSP00000158963   ⟸   ENSMUST00000239098
RefSeq Acc Id: ENSMUSP00000151741   ⟸   ENSMUST00000219763
RefSeq Acc Id: ENSMUSP00000140716   ⟸   ENSMUST00000189575
Protein Domains
Laminin EGF-like   Laminin G   Laminin G-like   Laminin IV type A   Laminin N-terminal

Promoters
RGD ID:8671708
Promoter ID:EPDNEW_M13885
Type:single initiation site
Name:Lama2_2
Description:Mus musculus laminin, alpha 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13886  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381027,195,713 - 27,195,773EPDNEW
RGD ID:8671710
Promoter ID:EPDNEW_M13886
Type:initiation region
Name:Lama2_1
Description:Mus musculus laminin, alpha 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13885  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381027,616,865 - 27,616,925EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99912 AgrOrtholog
Ensembl Genes ENSMUSG00000019899 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000092639 ENTREZGENE
  ENSMUST00000092639.12 UniProtKB/Swiss-Prot
  ENSMUST00000189575.2 UniProtKB/TrEMBL
  ENSMUST00000219763.2 UniProtKB/TrEMBL
  ENSMUST00000239098.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyl-accepting chemotaxis protein UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_aI UniProtKB/Swiss-Prot
  Laminin_dom_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16773 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99912 ENTREZGENE
NCBI Gene 16773 ENTREZGENE
PANTHER AXOTACTIN UniProtKB/TrEMBL
  LAMININ SUBUNIT ALPHA-2 UniProtKB/TrEMBL
  LAMININ SUBUNIT ALPHA-LIKE PROTEIN UniProtKB/TrEMBL
  LAMININ SUBUNIT GAMMA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NETRIN/LAMININ-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIKACHURIN-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Laminin_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_I UniProtKB/Swiss-Prot
  Laminin_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lama2 PhenoGen
PRINTS EGFLAMININ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_LAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAMININ_IVA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAMININ_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Lam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyl-accepting chemotaxis protein (MCP) signaling domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WRP2_MOUSE UniProtKB/TrEMBL
  A0A1W2P7N3_MOUSE UniProtKB/TrEMBL
  A0A5F8MPG7_MOUSE UniProtKB/TrEMBL
  F8VQ43 ENTREZGENE
  LAMA2_MOUSE UniProtKB/Swiss-Prot
  Q05003 ENTREZGENE
  Q5DTP0_MOUSE UniProtKB/TrEMBL
  Q60675 ENTREZGENE
  Q64061 ENTREZGENE
  Q7TQI9_MOUSE UniProtKB/TrEMBL
  Q8C9J2_MOUSE UniProtKB/TrEMBL
  Q8R145_MOUSE UniProtKB/TrEMBL
  Q924X5_MOUSE UniProtKB/TrEMBL
UniProt Secondary F8VQ43 UniProtKB/Swiss-Prot
  Q05003 UniProtKB/Swiss-Prot
  Q64061 UniProtKB/Swiss-Prot