Casp3 (caspase 3) - Rat Genome Database

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Gene: Casp3 (caspase 3) Rattus norvegicus
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Symbol: Casp3
Name: caspase 3
RGD ID: 2275
Description: Enables several functions, including death receptor binding activity; phospholipase A2 activator activity; and protease binding activity. Involved in several processes, including nervous system development; positive regulation of amyloid-beta formation; and response to anesthetic. Located in cytoplasm and neuronal cell body. Part of death-inducing signaling complex. Used to study artery disease (multiple); brain disease (multiple); and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach cancer. Orthologous to human CASP3 (caspase 3); PARTICIPATES IN apoptotic cell death pathway; intrinsic apoptotic pathway; extrinsic apoptotic pathway; INTERACTS WITH (+)-artemisinin; (+)-catechin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apopain; CASP-3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase-3; CPP-32; CPP32-beta; CPP32beta; cysteine protease CPP32; cysteine protease p32-beta; IRP; Lice; MGC93645; SCA-1; SREBP cleavage activity 1; Yama
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   F344-Tg(NC1-269B17)2Nkg   F344-Tg(NC1-269B17)3Nkg   F344-Tg(NC1-269B17)4Nkg   F344-Tg(NC1-269B17)1Nkg  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,395,539 - 52,413,794 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1652,395,540 - 52,413,732 (-)EnsemblGRCr8
mRatBN7.21645,662,910 - 45,681,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1645,662,910 - 45,684,648 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1651,061,544 - 51,079,742 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01654,429,112 - 54,447,305 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01649,700,916 - 49,719,114 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01648,845,011 - 48,863,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,845,012 - 48,863,204 (-)Ensemblrn6Rnor6.0
Rnor_5.01648,560,090 - 48,578,325 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41648,944,226 - 48,962,420 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1643,665,975 - 43,684,168 (-)NCBICelera
RGSC_v3.11648,944,301 - 48,962,495 (-)NCBI
Cytogenetic Map16q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
Acute Liver Failure  (IEP)
Acute Lung Injury  (IEP,ISO)
acute myocardial infarction  (IEP)
acute necrotizing pancreatitis  (IEP)
alcohol use disorder  (IEP)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (IEP)
atherosclerosis  (IEP)
bacterial infectious disease  (ISO)
Binge Drinking  (IEP)
Brain Contusion  (IEP)
brain glioma  (IDA)
Brain Hypoxia-Ischemia  (IDA,IEP)
Brain Injuries  (IEP)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
bronchopulmonary dysplasia  (IEP)
Burns  (IEP)
calcinosis  (ISO)
cataract  (IEP)
Cerebral Hemorrhage  (IEP,ISO)
cervical cancer  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
chemical colitis  (ISO)
Chronic Hepatitis  (ISO)
chronic obstructive pulmonary disease  (IEP)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (IEP)
Contrast-Induced Nephropathy  (IDA)
Copper-Overload Cirrhosis  (ISO)
cryptorchidism  (IEP,ISO)
diabetes mellitus  (IEP)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IEP)
diabetic neuropathy  (IEP,ISO)
diabetic retinopathy  (IEP,ISO)
dilated cardiomyopathy  (IEP)
Edema  (ISO)
endometritis  (IEP)
Endotoxemia  (IEP)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Myocarditis  (IEP,ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Mammary Neoplasms  (IDA,IEP)
Experimental Radiation Injuries  (IEP)
Fetal Growth Retardation  (IEP)
gastric ulcer  (IEP)
heart disease  (IEP)
heart valve disease  (ISO)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (IEP)
Huntington's disease  (ISO)
Hypercholesterolemia  (IEP)
hypertension  (IDA,IEP)
hyperthyroidism  (IEP)
hypertrophic cardiomyopathy  (IEP)
Hypoxia  (IEP)
impotence  (IEP)
Insulin Resistance  (IEP)
intermittent claudication  (IDA)
intestinal disease  (IEP)
Intestinal Reperfusion Injury  (IEP)
kidney disease  (IEP)
Kidney Reperfusion Injury  (IEP)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP)
middle cerebral artery infarction  (IDA,IEP)
Mycoplasma Infections  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP,IMP,ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
osteoarthritis  (IEP)
Osteoarthritis, Experimental  (IEP)
Oxygen-Induced Retinopathy  (ISO)
pancreatitis  (IEP)
Parkinson's disease  (ISO)
Parkinsonism  (IDA,IEP,ISO)
Postoperative Cognitive Dysfunction  (IEP)
pre-malignant neoplasm  (IDA)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IDA,IMP,ISO)
retinal detachment  (ISO)
retinal disease  (IEP)
salivary gland disease  (ISO)
sciatic neuropathy  (IEP)
scrapie  (ISO)
Sepsis  (IEP,ISO)
severe acute respiratory syndrome  (ISO)
spermatic cord torsion  (IEP)
Spinal Cord Injuries  (IDA,IEP,IMP,ISO)
status epilepticus  (IEP,ISO)
stomach cancer  (ISO)
stroke  (IEP)
Subarachnoid Hemorrhage  (IDA,ISO)
Testis Reperfusion Injury  (IEP)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (IDA)
transitional cell carcinoma  (ISO)
Transplant Rejection  (IEP)
traumatic brain injury  (IEP)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (IEP)
urinary bladder cancer  (ISO)
Ventricular Remodeling  (ISO)
Viral Myocarditis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (ISO)
(+)-albicanol  (ISO)
(+)-alpha-viniferin  (ISO)
(+)-artemisinin  (EXP,ISO)
(+)-catechin  (EXP,ISO)
(+)-conocarpan  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-sesamin  (EXP,ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-bornyl-caffeate  (EXP)
(-)-citrinin  (EXP,ISO)
(-)-cotinine  (ISO)
(-)-demecolcine  (ISO)
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-gambogic acid  (ISO)
(-)-matairesinol  (ISO)
(-)-noscapine  (ISO)
(-)-selegiline  (ISO)
(-)-voacangine  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (ISO)
(aminomethyl)phosphonic acid  (ISO)
(E)-thiamethoxam  (ISO)
(E,E)-germacrone  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-carnitine  (EXP,ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-salsolinol  (EXP,ISO)
(R,R)-tramadol  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-AMPA  (EXP)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (EXP,ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-dinitrobenzene  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1,4-naphthoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP,ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP,ISO)
1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol  (ISO)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-hydroxy-1-norresistomycin  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-monopalmitoylglycerol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
10-Hydroxycamptothecin  (ISO)
12-methyltetradecanoic acid  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP,ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2'-deoxycytidine  (ISO)
2'-deoxyguanosine  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP,ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,5-trichlorophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-diaminobutyric acid  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2,4-Dihydroxychalcone  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-dimethylcelecoxib  (ISO)
2,5-hexanedione  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-aminobiphenyl  (ISO)
2-aminoethoxydiphenylborane  (EXP)
2-arachidonoylglycerol  (ISO)
2-cyclopenten-1-one  (ISO)
2-deoxy-D-glucose  (EXP,ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methoxyethanol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-methylcholine  (ISO)
2-nitropropane  (ISO)
2-pyridylethylamine  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP,ISO)
2-trans,6-trans-farnesyl diphosphate  (EXP,ISO)
20-hydroxyecdysone  (ISO)
25-hydroxycholesterol  (EXP,ISO)
28-deoxonimbolide  (ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3',4'-dimethoxyflavone  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-Dichlorobenzidine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,7-dihydropurine-6-thione  (EXP)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-aminobenzamide  (EXP,ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP,ISO)
3-phenoxybenzoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-amino-1,8-naphthalimide  (ISO)
4-aminopyridine  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxyhexenal  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
4-nitro-m-cresol  (ISO)
4-nitroaniline  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-tert-Octylphenol  (ISO)
4-Vinylcyclohexene  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-aminolevulinic acid  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (EXP,ISO)
5-formyltetrahydrofolic acid  (ISO)
5-Geranyloxy-7-methoxycoumarin  (ISO)
5-Hydroxycapric acid  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxypsoralen  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-decylubiquinone  (EXP)
6-formylpterin  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7,8-dihydroxycoumarin  (ISO)
7-ketocholesterol  (EXP,ISO)
7alpha-hydroxycholesterol  (ISO)
7H-xanthine  (EXP,ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
8-OH-DPAT  (ISO)
9'-cis-neoxanthin  (ISO)
9,10-anthraquinone  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
9-hydroxycanthin-6-one  (ISO)
9-Methoxycamptothecin  (ISO)
9H-xanthine  (EXP,ISO)
[6]-Shogaol  (ISO)
AB-Fubinaca  (ISO)
abamectin  (EXP,ISO)
Abemaciclib  (ISO)
abexinostat  (ISO)
ABT-737  (ISO)
acadesine  (EXP,ISO)
acetaldehyde  (ISO)
acetamiprid  (EXP)
acetazolamide  (ISO)
acetic acid  (EXP)
acetochlor  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP,ISO)
aclacinomycin A  (ISO)
aconitine  (EXP,ISO)
acridines  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (EXP,ISO)
adenosine  (EXP,ISO)
Aeroplysinin 1  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
aflatoxin M1  (ISO)
afzelechin  (EXP)
agathisflavone  (EXP)
AH23848  (ISO)
AICA ribonucleotide  (EXP,ISO)
ajmalicine  (ISO)
Alamandine  (EXP)
alantolactone  (ISO)
alborixin  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (EXP)
aldicarb  (EXP)
aldosterone  (EXP)
aldrithiol  (EXP)
alendronic acid  (ISO)
alginic acid  (ISO)
aliskiren  (EXP)
all-trans-acitretin  (ISO)
all-trans-neoxanthin  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allethrin  (EXP,ISO)
allopurinol  (EXP)
alloxan  (EXP)
Allyl chloride  (EXP)
allyl isothiocyanate  (ISO)
Aloe emodin  (ISO)
alogliptin  (EXP)
Aloperine  (EXP)
aloxistatin  (EXP,ISO)
alpha-amanitin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-ergocryptine  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-Solamarine  (ISO)
alpidem  (ISO)
Alpinetin  (ISO)
alpinumisoflavone  (ISO)
alprazolam  (ISO)
alsterpaullone  (EXP)
alternariol  (ISO)
aluminium atom  (EXP,ISO)
aluminium oxide  (EXP,ISO)
aluminium(0)  (EXP,ISO)
alvocidib  (EXP,ISO)
amarogentin  (ISO)
ambrisentan  (ISO)
amentoflavone  (ISO)
amidotrizoic acid  (EXP,ISO)
amifostine  (ISO)
amiloride  (EXP,ISO)
amino acid  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (EXP,ISO)
amitriptyline  (EXP)
amitrole  (EXP,ISO)
amlexanox  (ISO)
amlodipine  (EXP,ISO)
ammonia  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amosite asbestos  (ISO)
amoxicillin  (ISO)
amphetamine  (EXP,ISO)
amphotericin B  (ISO)
anandamide  (ISO)
andrographolide  (EXP,ISO)
Anemoside B4  (ISO)
anethole  (EXP)
anilines  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene  (ISO)
antimony trichloride  (ISO)
antimony(0)  (EXP,ISO)
ANTIMYCIN  (ISO)
antimycin A  (EXP,ISO)
Antrocin  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
apremilast  (EXP)
aprepitant  (ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arecoline  (EXP,ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (EXP,ISO)
arjunolic acid  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsanilic acid  (EXP)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
Arsenobetaine  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
ARV-825  (ISO)
asiatic acid  (EXP,ISO)
Asimicin  (ISO)
aspartame  (EXP,ISO)
Aspidin  (ISO)
astaxanthin  (EXP,ISO)
astilbin  (ISO)
astragaloside IV  (EXP,ISO)
atenolol  (ISO)
Atipamezole  (EXP)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
Atractylenolide III  (ISO)
Atranorin  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
aucubin  (ISO)
Augmentin  (EXP)
auranofin  (EXP,ISO)
aurantio-obtusin  (ISO)
aureusidin  (ISO)
Auriculasin  (ISO)
azadirachtin A  (ISO)
azadiradione  (ISO)
Azaspiracid  (ISO)
azithromycin  (EXP,ISO)
Azoxymethane  (EXP,ISO)
azoxystrobin  (ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
BAPTA  (ISO)
bathocuproine disulfonic acid  (EXP)
Bay-K-8644  (ISO)
bazedoxifene  (ISO)
beauvericin  (EXP,ISO)
belinostat  (ISO)
bellidifolin  (ISO)
benidipine  (EXP)
benzalkonium chloride  (ISO)
benzamide  (ISO)
benzbromarone  (EXP)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (EXP,ISO)
benzoates  (ISO)
benzophenanthridine  (ISO)
benzyl isothiocyanate  (ISO)
beraprost  (ISO)
Berbamine  (ISO)
berberine  (EXP,ISO)
Berberrubine  (ISO)
Bergenin  (ISO)
beta-amyrin  (EXP)
beta-carboline  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
beta-Elemonic acid  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-ionone  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-patchoulene  (EXP)
Beta-Solamarine  (ISO)
beta-tocopherol  (EXP,ISO)
betaxolol  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bicuculline  (ISO)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (EXP,ISO)
biliverdin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bleomycin A5  (ISO)
boric acid  (ISO)
boron atom  (ISO)
borrelidin  (ISO)
bortezomib  (ISO)
bosentan  (EXP)
BQ 123  (EXP)
brassinin  (ISO)
brassinolide  (ISO)
brazilin  (ISO)
brefeldin A  (ISO)
brilliant green  (ISO)
bromodichloromethane  (ISO)
bromuconazole  (EXP)
brucine  (ISO)
Brusatol  (EXP,ISO)
bucladesine  (ISO)
budesonide  (ISO)
bufalin  (ISO)
Bufotalin  (ISO)
bupivacaine  (EXP,ISO)
buprofezin  (ISO)
bupropion  (ISO)
buserelin  (ISO)
buspirone  (EXP)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butachlor  (ISO)
butan-1-ol  (EXP)
butane-2,3-dione  (ISO)
butein  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP,ISO)
C60 fullerene  (ISO)
cabazitaxel  (ISO)
Cacalol  (ISO)
cadmium acetate  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cadmium telluride  (ISO)
cafestol  (ISO)
caffeine  (EXP,ISO)
cajanol  (ISO)
Calcimycin  (EXP,ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium carbonate  (ISO)
calcium dichloride  (EXP)
calcium oxalate  (ISO)
calcium(0)  (EXP,ISO)
calmidazolium  (ISO)
Calpeptin  (EXP,ISO)
calycosin  (EXP)
calycosin-7-O-beta-D-glucoside  (ISO)
camphene  (EXP)
camptothecin  (EXP,ISO)
canagliflozin  (ISO)
candesartan  (EXP)
cannabidiol  (EXP,ISO)
cantharidic acid  (ISO)
cantharidin  (EXP,ISO)
capillarisin  (ISO)
capivasertib  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captan  (ISO)
captopril  (EXP,ISO)
carbachol  (EXP,ISO)
carbamate ester  (ISO)
carbamazepine  (EXP,ISO)
carbaryl  (EXP)
carbendazim  (EXP,ISO)
CARBENOXOLONE  (EXP,ISO)
carbidopa  (ISO)
carbimazole  (EXP)
carbofuran  (EXP,ISO)
carbon atom  (ISO)
carbon disulfide  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP,ISO)
carboxy-PTIO  (ISO)
Cardamonin  (ISO)
carfilzomib  (EXP,ISO)
carmustine  (EXP,ISO)
carnosic acid  (EXP,ISO)
carnosine  (EXP,ISO)
Carnosol  (ISO)
carvacrol  (EXP,ISO)
carvedilol  (EXP,ISO)
casticin  (EXP,ISO)
catalpol  (ISO)
catechol  (ISO)
CCCP  (EXP,ISO)
CDP-choline  (ISO)
CEDRELONE  (ISO)
cefalotin  (ISO)
celastrol  (EXP,ISO)
celecoxib  (EXP,ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
cerivastatin  (ISO)
cerulenin  (ISO)
ceruletide  (EXP)
cetrorelix  (EXP,ISO)
cetylpyridinium  (ISO)
CGP 52608  (ISO)
chalcone  (ISO)
chalcones  (ISO)
chelerythrine  (EXP,ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chitosan  (EXP,ISO)
chlorambucil  (ISO)
chloramphenicol  (ISO)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
Chloroacetonitrile  (ISO)
chlorogenic acid  (EXP,ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chondroitin sulfate  (ISO)
chromium atom  (EXP,ISO)
chromium trioxide  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (EXP,ISO)
chromone  (ISO)
chrysazin  (ISO)
chrysene  (ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (EXP)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cilnidipine  (EXP,ISO)
cilostazol  (EXP,ISO)
cimetidine  (EXP,ISO)
cinchocaine  (EXP)
Cinobufotalin  (ISO)
ciprofloxacin  (EXP,ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP,ISO)
citric acid  (ISO)
cladribine  (ISO)
clavulone II  (ISO)
Clivoline  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
clofarabine  (ISO)
clofibrate  (EXP)
clomipramine  (ISO)
clonidine  (EXP,ISO)
clonidine (amino form)  (EXP,ISO)
clonidine (imino form)  (EXP,ISO)
clorgyline  (ISO)
clotrimazole  (ISO)
cloxacillin  (ISO)
clozapine  (EXP,ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (EXP)
cocaine  (EXP,ISO)
codeinone  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
colistin  (EXP,ISO)
concanamycin A  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
coptisine  (ISO)
cordycepin  (EXP,ISO)
corilagin  (EXP,ISO)
corosolic acid  (EXP,ISO)
corticosterone  (EXP)
cortisol  (EXP,ISO)
cortisone  (EXP)
coumarin  (ISO)
coumestrol  (EXP,ISO)
creatine  (EXP)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP,ISO)
crotonaldehyde  (EXP)
Cryptotanshinone  (ISO)
crystal violet  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (ISO)
cucurbitacin E  (EXP,ISO)
cucurbitacin I  (ISO)
cudraflavone B  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cyclizine  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyprodinil  (ISO)
cyproheptadine  (EXP)
cytarabine  (EXP,ISO)
cytochalasin B  (ISO)
D-aspartic acid  (EXP)
D-glucitol  (EXP,ISO)
D-gluconic acid  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
D-penicillamine  (EXP,ISO)
D-ribofuranose  (EXP)
dacarbazine  (ISO)
dactolisib  (ISO)
daidzein  (EXP,ISO)
dantrolene  (EXP,ISO)
dapagliflozin  (EXP)
dapoxetine  (EXP)
DAPT  (EXP)
daunorubicin  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deferasirox  (ISO)
deferiprone  (ISO)
deguelin  (ISO)
dehydrocostus lactone  (ISO)
delphinidin  (ISO)
delta-hexachlorocyclohexane  (ISO)
delta-tocopherol  (EXP)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
Dendrobine  (ISO)
deoxycholic acid  (EXP,ISO)
deoxynivalenol  (EXP,ISO)
Deoxyschizandrin  (ISO)
Deoxyshikonin  (ISO)
desferrioxamine B  (EXP,ISO)
desipramine  (EXP,ISO)
desloratadine  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (EXP,ISO)
dexmedetomidine  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diacetylmonoxime  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
diazoxide  (EXP)
dibenz[a,h]anthracene  (EXP)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibromoacetic acid  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dichloroacetyl chloride  (ISO)
dichloromethane  (ISO)
dichlorvos  (EXP,ISO)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
Didecyldimethylammonium  (ISO)
dideuterium oxide  (ISO)
Didymin  (ISO)
dieckol  (ISO)
dieldrin  (EXP,ISO)
diepoxybutane  (ISO)
diethanolamine  (EXP,ISO)
diethyl fumarate  (ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethyl sulfate  (ISO)
diethyldithiocarbamic acid  (EXP,ISO)
diethylstilbestrol  (ISO)
difenoconazole  (EXP)
digitoxin  (ISO)
dihydroactinidiolide  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydrogen  (ISO)
dihydrolipoic acid  (ISO)
dihydrosanguinarine  (ISO)
dihydroxyacetone  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
diminazene diaceturate  (ISO)
dinaciclib  (ISO)
dioscin  (EXP,ISO)
diosgenin  (EXP,ISO)
diosmetin  (EXP)
diosmin  (EXP,ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diprotium  (ISO)
diprotium oxide  (EXP)
dipyridamole  (ISO)
diquat  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP,ISO)
dithionite(2-)  (EXP,ISO)
divanadium pentaoxide  (EXP)
dizocilpine maleate  (EXP,ISO)
docebenone  (ISO)
dodecanoic acid  (ISO)
Dodecyl gallate  (ISO)
domoic acid  (ISO)
donepezil hydrochloride  (EXP,ISO)
dopamine  (EXP,ISO)
dopaminechrome (enol form)  (EXP)
doramapimod  (ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
drimenol  (ISO)
dronedarone  (ISO)
duvoglustat  (EXP)
ebselen  (EXP,ISO)
Echimidine  (ISO)
echinacoside  (ISO)
Echinocystic acid  (ISO)
edaravone  (EXP,ISO)
efavirenz  (EXP,ISO)
EHT 1864  (ISO)
elaidic acid  (EXP)
elemental boron  (ISO)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
ellipticine  (ISO)
emamectin benzoate  (ISO)
embelin  (ISO)
emetine  (ISO)
emodin  (EXP,ISO)
empagliflozin  (EXP)
enalapril  (EXP)
endosulfan  (EXP,ISO)
enniatin  (EXP)
entacapone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
epalrestat  (ISO)
epothilone A  (ISO)
epoxomicin  (ISO)
equol  (ISO)
erastin  (ISO)
erdosteine  (EXP,ISO)
ergocristine  (ISO)
ergosine  (ISO)
ergosterol peroxide  (ISO)
ergotamine  (ISO)
ergothioneine  (EXP)
eritoran  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
escitalopram  (EXP)
esculetin  (ISO)
esketamine  (ISO)
estragole  (EXP)
estrone  (ISO)
etacrynic acid  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
Ethyl icosapentate  (EXP,ISO)
ethylbenzene  (EXP)
ethylene glycol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etodolac  (ISO)
etomidate  (ISO)
etoposide  (EXP,ISO)
eugenol  (EXP,ISO)
EUK-134  (ISO)
eumelanin  (ISO)
euscaphic acid  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP,ISO)
fangchinoline  (ISO)
farnesol  (EXP,ISO)
farnesyl diphosphate  (EXP,ISO)
farrerol  (ISO)
fasudil  (EXP)
favipiravir  (EXP)
febuxostat  (EXP)
fenbendazole  (ISO)
fenitrothion  (EXP)
fenofibrate  (EXP,ISO)
fenpropathrin  (EXP)
fenpyroximate  (ISO)
fenvalerate  (EXP,ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
ferrosoferric oxide  (ISO)
ferrostatin-1  (EXP,ISO)
ferrous oxide  (ISO)
ferruginol  (ISO)
ferulic acid  (EXP)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
fipronil  (EXP,ISO)
fisetin  (EXP,ISO)
flavanone  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
flavone  (ISO)
flavones  (ISO)
flavonoids  (ISO)
flavonols  (ISO)
flecainide  (ISO)
fluazinam  (ISO)
flubendazole  (ISO)
flucloxacillin  (ISO)
fludioxonil  (ISO)
flufenamic acid  (ISO)
flunitrazepam  (ISO)
fluorometholone  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
flutriafol  (EXP)
fluvastatin  (EXP,ISO)
fluvoxamine  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
formononetin  (EXP,ISO)
Forsythiaside  (ISO)
fostriecin  (ISO)
fraxetin  (ISO)
friedelin  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furazolidone  (ISO)
furosemide  (EXP)
Fusaric acid  (EXP)
gadolinium atom  (EXP,ISO)
gadolinium trichloride  (ISO)
galactose  (EXP,ISO)
galangin  (ISO)
galanthamine  (EXP)
galanthamine Trifluoroacetic acid  (EXP)
Galbanic acid  (ISO)
gallic acid  (EXP,ISO)
gallium atom  (ISO)
gallium nitrate  (ISO)
gamma-aminobutyric acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (EXP,ISO)
Ganoderic acid A  (ISO)
Ganoderic acid T  (ISO)
Garcinol  (ISO)
gardenin B  (ISO)
Gastrodin  (EXP,ISO)
gedunin  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
geneticin  (ISO)
Genipin  (ISO)
Geniposide  (EXP,ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP,ISO)
genkwanin  (ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
geranylgeraniol  (ISO)
gibberellin A3  (EXP)
gingerol  (EXP,ISO)
ginkgetin  (ISO)
Ginkgoic acid  (ISO)
ginkgolide B  (EXP,ISO)
Ginkgolide C  (EXP)
ginsenoside Rb1  (ISO)
ginsenoside Rd  (EXP)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (EXP)
Ginsenoside Rg5  (ISO)
glabridin  (ISO)
gliclazide  (EXP,ISO)
glimepiride  (ISO)
gliotoxin  (EXP,ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutinol  (ISO)
glyburide  (EXP,ISO)
glycerol  (EXP)
glycidol  (EXP)
glycine betaine  (EXP)
glycochenodeoxycholic acid  (EXP,ISO)
glycodeoxycholic acid  (EXP)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glycyrrhizinic acid  (EXP,ISO)
glyoxylic acid  (ISO)
glyphosate  (EXP,ISO)
Goe 6976  (EXP)
gold atom  (EXP,ISO)
gold(0)  (EXP,ISO)
gossypetin  (ISO)
gossypin  (ISO)
gossypol  (EXP,ISO)
graphite  (ISO)
Grifolin  (ISO)
griseofulvin  (ISO)
GSK690693  (ISO)
guaiazulene  (ISO)
guanidines  (ISO)
guanosine  (EXP)
guggulsterone  (ISO)
GW 1929  (ISO)
GW 3965  (EXP)
GW 6471  (ISO)
Gyrophoric acid  (ISO)
haloperidol  (EXP)
harmalol  (ISO)
harman  (ISO)
Harpagoside  (ISO)
helenalin  (ISO)
Heliotrine  (ISO)
hemin  (EXP,ISO)
heparin  (EXP,ISO)
herbacetin  (EXP)
herbicide  (ISO)
heroin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexaflumuron  (EXP)
hexane  (EXP)
hinokiflavone  (ISO)
histamine  (EXP)
homocysteine  (EXP,ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
HT-2 toxin  (ISO)
hyaluronic acid  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP,ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
hydroxytyrosol  (EXP,ISO)
hydroxyurea  (ISO)
hymexazol  (EXP)
hyperforin  (EXP,ISO)
hypoxanthine  (ISO)
ibuprofen  (EXP)
icariin  (EXP)
icariside II  (ISO)
icosanoid  (EXP)
idarubicin  (ISO)
idelalisib  (ISO)
ifosfamide  (EXP)
Ilimaquinone  (ISO)
imidacloprid  (EXP)
imipramine  (ISO)
imiquimod  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP)
inositol  (ISO)
Inostamycin  (ISO)
insulin  (EXP)
inulin  (ISO)
inuviscolide  (ISO)
iohexol  (EXP,ISO)
ionomycin  (ISO)
Ioversol  (EXP)
ipratropium  (EXP)
iprodione  (EXP)
irbesartan  (EXP,ISO)
irigenin  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
iron(III) nitrilotriacetate  (EXP)
isatin  (ISO)
isoalantolactone  (ISO)
Isoangustone A  (ISO)
isocarbophos  (EXP)
isoflavones  (EXP)
isoflurane  (EXP,ISO)
Isoliensinine  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
jaceosidin  (ISO)
JBIR-99  (ISO)
juglone  (ISO)
Jujuboside A  (ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
kainic acid  (EXP,ISO)
kenpaullone  (ISO)
ketamine  (EXP,ISO)
ketoconazole  (ISO)
KN-93  (EXP,ISO)
KT 5720  (EXP,ISO)
KT 5823  (ISO)
Kukoamine B  (ISO)
kurarinol  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cystathionine  (ISO)
L-dehydroascorbic acid  (ISO)
L-ethionine  (EXP)
L-gamma-glutamyl-L-cysteine  (EXP)
L-glutamic acid  (EXP,ISO)
L-leucine  (ISO)
L-methionine  (EXP,ISO)
L-mimosine  (ISO)
lactacystin  (EXP,ISO)
lactucin  (ISO)
lactulose  (EXP)
lamivudine  (EXP)
lanreotide  (EXP)
lansoprazole  (EXP,ISO)
lanthanum trichloride  (EXP)
lapatinib  (ISO)
latrunculin A  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (EXP,ISO)
Leonurine  (EXP,ISO)
letrozole  (EXP)
leuprolide  (ISO)
levetiracetam  (EXP)
levocabastine  (ISO)
levofloxacin  (ISO)
LGK974  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
licoricidin  (ISO)
lidocaine  (EXP,ISO)
Liensinine  (ISO)
limonin  (ISO)
linagliptin  (ISO)
linalool  (ISO)
linderalactone  (ISO)
linsidomine  (EXP,ISO)
linuron  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
liraglutide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium carbonate  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (ISO)
litreol  (ISO)
LM-1685  (ISO)
Lobetyolin  (ISO)
loganin  (ISO)
lonafarnib  (ISO)
Longikaurin A  (ISO)
lonidamine  (ISO)
loratadine  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
lupeol  (EXP,ISO)
Lupiwighteone  (ISO)
luteolin  (EXP,ISO)
Luteolin 7-methyl ether  (EXP)
luteolin 7-O-beta-D-glucoside  (ISO)
LY 379268  (EXP)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
lysophosphatidylcholine  (ISO)
lysophosphatidylethanolamine  (ISO)
maculosin  (ISO)
madecassoside  (ISO)
Maduramicin  (EXP,ISO)
magnesium dichloride  (EXP,ISO)
magnesium oxide  (ISO)
Magnolol  (ISO)
malathion  (EXP,ISO)
malic acid  (ISO)
malonic acid  (EXP)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manumycin A  (ISO)
Maprotiline  (ISO)
masoprocol  (EXP,ISO)
MC1568  (EXP,ISO)
mebendazole  (ISO)
mechlorethamine  (ISO)
meglumine amidotrizoate  (EXP,ISO)
MeIQx  (ISO)
melamine  (ISO)
Melarsoprol  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (EXP,ISO)
melphalan  (ISO)
memantine  (EXP,ISO)
menadione  (EXP,ISO)
menaquinone  (ISO)
mephedrone  (ISO)
mercaptopurine  (EXP)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methapyrilene  (EXP)
methimazole  (EXP,ISO)
methomyl  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl beta-cyclodextrin  (ISO)
methyl caffeate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP,ISO)
methylcobalamin  (ISO)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (EXP)
Methylone  (EXP)
methylparaben  (ISO)
methylphenidate  (EXP,ISO)
methylseleninic acid  (ISO)
methyltestosterone  (EXP)
metipranolol  (EXP,ISO)
metiram  (ISO)
metoclopramide  (ISO)
metoprolol  (ISO)
mevalonic acid  (EXP,ISO)
mevinphos  (EXP)
micafungin  (EXP,ISO)
miconazole  (ISO)
microcystin-LR  (EXP,ISO)
midostaurin  (ISO)
mifepristone  (EXP,ISO)
Miltirone  (ISO)
minocycline  (EXP,ISO)
mirabegron  (EXP)
mirtazapine  (ISO)
misoprostol  (EXP)
mitomycin C  (ISO)
Mitoquinone  (EXP,ISO)
Mitotane  (EXP,ISO)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
MK 571  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
molibresib  (ISO)
molybdenum atom  (ISO)
monensin A  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
montelukast  (EXP,ISO)
morin  (EXP,ISO)
morphine  (EXP,ISO)
morphinone  (ISO)
Morroniside  (EXP,ISO)
morusin  (ISO)
motexafin gadolinium  (ISO)
Muconic dialdehyde  (ISO)
muscimol  (ISO)
mycophenolic acid  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
myricitrin  (ISO)
myriocin  (ISO)
myristicin  (ISO)
Myrtucommulone A  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (EXP,ISO)
N,N-dimethylsphingosine  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP,ISO)
N-(3-oxododecanoyl)homoserine lactone  (ISO)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (ISO)
N-(p-amylcinnamoyl)anthranilic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetyl-L-tryptophan  (ISO)
N-acetylsphingosine  (ISO)
N-acylsphinganine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-phosphocreatine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nafcillin  (ISO)
naloxone  (ISO)
Nandrolone decanoate  (EXP)
naphthalene  (ISO)
naringin  (EXP,ISO)
navitoclax  (ISO)
NCX-4040  (ISO)
nectandrin B  (ISO)
nefazodone  (EXP,ISO)
Neferine  (EXP,ISO)
nelfinavir  (ISO)
neoastilbin  (ISO)
neocuproine  (EXP,ISO)
neohesperidin dihydrochalcone  (ISO)
Neoisoliquiritin  (ISO)
neomycin  (ISO)
Neosolaniol  (ISO)
nerolidol  (ISO)
nevadensin  (ISO)
nevirapine  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel ferrite  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP,ISO)
nicorandil  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (EXP,ISO)
Niflumic acid  (ISO)
nifuroxazide  (EXP)
nigericin  (ISO)
nilotinib  (EXP,ISO)
nimesulide  (EXP,ISO)
nimetazepam  (ISO)
nimodipine  (EXP,ISO)
nimustine  (ISO)
Nitidine  (ISO)
nitrazepam  (ISO)
nitric oxide  (EXP,ISO)
nitrofen  (ISO)
nitroglycerin  (ISO)
nitroprusside  (EXP,ISO)
nitroxyl  (ISO)
Nivalenol  (ISO)
NMS-873  (ISO)
nobiletin  (EXP,ISO)
nocodazole  (ISO)
Nonylphenol  (EXP,ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
nortriptyline  (ISO)
norwogonin  (EXP)
notoginsenoside R1  (EXP,ISO)
NS-398  (EXP,ISO)
NSC 23766  (ISO)
Nutlin-3  (ISO)
O-acetyl-L-carnitine  (EXP)
O-methyleugenol  (EXP,ISO)
Obacunone  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP,ISO)
Octachlorostyrene  (ISO)
octadecanoic acid  (EXP)
octhilinone  (ISO)
octreotide  (ISO)
octyl gallate  (ISO)
okadaic acid  (EXP,ISO)
olaparib  (ISO)
oleamide  (ISO)
oleandrigenin  (ISO)
oleandrin  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
olesoxime  (ISO)
oleuropein  (ISO)
oligopeptide  (EXP,ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (EXP)
oltipraz  (ISO)
omacetaxine mepesuccinate  (ISO)
omeprazole  (EXP,ISO)
omipalisib  (ISO)
Ondansetron  (EXP,ISO)
organoselenium compound  (ISO)
oridonin  (EXP,ISO)
orlistat  (EXP,ISO)
oroxylin A  (ISO)
Ortho-topolin riboside  (ISO)
osimertinib  (ISO)
osthole  (EXP,ISO)
ouabain  (EXP,ISO)
oxalic acid  (ISO)
oxaliplatin  (EXP,ISO)
oxcarbazepine  (EXP)
oxfendazole  (EXP)
oxidopamine  (EXP,ISO)
oxirane  (ISO)
oxybenzone  (EXP)
oxybuprocaine  (ISO)
ozone  (EXP,ISO)
P(1),P(4)-bis(5'-adenosyl) tetraphosphate  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP,ISO)
palbociclib  (ISO)
pamidronate  (ISO)
panaxydol  (EXP)
Panaxynol  (EXP)
Pancratistatin  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (EXP)
paroxetine  (ISO)
Parthenin  (ISO)
parthenolide  (EXP)
patulin  (ISO)
PCB138  (ISO)
PD 168393  (ISO)
pefloxacin  (ISO)
pendimethalin  (EXP)
Pendulone  (ISO)
pentachlorophenol  (EXP,ISO)
pentetic acid  (ISO)
pentetrazol  (EXP)
Pentoxifylline  (EXP,ISO)
pepstatin A  (EXP,ISO)
perchlorate  (EXP)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perifosine  (ISO)
permethrin  (EXP)
peroxynitrous acid  (EXP,ISO)
pevonedistat  (ISO)
pexidartinib  (ISO)
PF-4708671  (EXP)
PHA-665752  (ISO)
phenanthrene  (ISO)
phencyclidine  (EXP)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phentolamine  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
phenylmethanesulfonyl fluoride  (ISO)
PhIP  (EXP,ISO)
phloretin  (ISO)
phloroglucinol  (ISO)
phorate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phosphoramide mustard  (EXP)
phylloquinone  (ISO)
phytol  (ISO)
Phytolaccoside E  (ISO)
phytosphingosine  (ISO)
piclamilast  (EXP)
picolinic acid  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
Pinacidil  (EXP)
pinostrobin  (EXP,ISO)
pioglitazone  (EXP,ISO)
piperazine  (ISO)
piperidine  (ISO)
piperine  (ISO)
piperonyl butoxide  (EXP)
pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
PK-11195  (ISO)
Plantamajoside  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (ISO)
plumbagin  (EXP,ISO)
pluronic P-123  (EXP)
podophyllotoxin  (ISO)
polaprezinc  (EXP)
Poloxamer  (EXP)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (ISO)
Polygodial  (ISO)
polymyxin B2  (ISO)
pomalidomide  (ISO)
ponasterone A  (EXP)
ponatinib  (ISO)
Ponicidin  (ISO)
porphyrins  (ISO)
potassium atom  (EXP)
potassium bromate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
Pramanicin  (ISO)
pramipexole  (EXP)
Pranoprofen  (ISO)
pravastatin  (EXP,ISO)
prednisolone  (EXP)
pregabalin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
proanthocyanidin  (ISO)
procaine  (ISO)
procyanidin B1  (ISO)
procyanidin B2  (EXP,ISO)
procymidone  (ISO)
prodigiosin  (EXP,ISO)
profenofos  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propacetamol  (ISO)
propafenone  (ISO)
propan-2-ol  (EXP)
propiconazole  (EXP)
propionic acid  (EXP)
propofol  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin D2  (EXP,ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (EXP,ISO)
prostaglandin J2  (EXP,ISO)
protein kinase inhibitor  (EXP,ISO)
Protolichesterinic acid  (ISO)
protoporphyrin  (EXP,ISO)
protosappanin A  (EXP)
Pseudolaric acid B  (ISO)
psoralen  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
Pulsatilla saponin D  (ISO)
punicalagin  (EXP,ISO)
purine-6-thiol  (EXP)
purmorphamine  (EXP)
puromycin  (ISO)
putrescine  (EXP)
pyrazinecarboxamide  (EXP,ISO)
pyrene  (EXP,ISO)
pyrethrins  (EXP,ISO)
pyridaben  (EXP)
Pyridostigmine bromide  (ISO)
pyrimethamine  (ISO)
pyrimethanil  (ISO)
pyriproxyfen  (ISO)
pyrogallol  (ISO)
pyrroles  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrroloquinoline quinone  (EXP,ISO)
pyruvic acid  (EXP)
pyrvinium  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP,ISO)
quercetin 3-O-beta-D-glucopyranoside  (EXP,ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quercitrin  (EXP,ISO)
quinacrine  (ISO)
quinoline  (ISO)
quinolines  (ISO)
quinolinic acid  (EXP)
quizartinib  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
rac-lactic acid  (ISO)
radicicol  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP,ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
regorafenib  (ISO)
remdesivir  (ISO)
remifentanil  (EXP)
Repaglinide  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
RGFP966  (ISO)
Rhein  (ISO)
Rhynchophylline  (EXP)
ribavirin  (ISO)
riboflavin  (ISO)
ricolinostat  (ISO)
rifampicin  (EXP,ISO)
Riluzole  (ISO)
rimonabant  (ISO)
Risedronate sodium  (EXP)
risperidone  (ISO)
ritonavir  (ISO)
rivastigmine  (EXP)
Ro 31-8220  (EXP,ISO)
robinin  (EXP)
roflumilast  (EXP,ISO)
rolipram  (EXP)
romidepsin  (ISO)
ropinirole  (ISO)
rosmarinic acid  (EXP,ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
royal jelly  (EXP,ISO)
rubimaillin  (ISO)
rubitecan  (ISO)
rucaparib  (ISO)
Rutecarpine  (ISO)
ruthenium atom  (ISO)
ruthenium red  (ISO)
rutin  (EXP,ISO)
ryanodine  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (EXP,ISO)
S-adenosyl-L-methionine  (EXP,ISO)
S-allylcysteine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-methylglutathione  (ISO)
S-nitroso-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP,ISO)
S-nitrosoglutathione  (ISO)
S63845  (ISO)
saccharin  (EXP)
safrole  (ISO)
Salidroside  (EXP,ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (EXP)
Sanggenon C  (EXP,ISO)
sanguinarine  (ISO)
sapanisertib  (ISO)
sappanchalcone  (ISO)
sarpogrelate  (ISO)
Satratoxin H  (EXP)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 415286  (EXP)
SB 431542  (EXP,ISO)
SB-239063  (ISO)
SCH 23390  (ISO)
Schizandrin  (EXP)
sclareol  (ISO)
scoparone  (ISO)
scopolamine  (EXP,ISO)
scopoletin  (EXP,ISO)
scullcapflavone II  (ISO)
scutellarin  (EXP,ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenic acid  (ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
selumetinib  (ISO)
semaglutide  (EXP,ISO)
semilicoisoflavone B  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sepantronium  (ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
sertraline  (ISO)
Sesamol  (EXP,ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP,ISO)
Shikonin  (EXP,ISO)
sibutramine  (ISO)
sildenafil citrate  (EXP,ISO)
silibinin  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (EXP,ISO)
sirtinol  (EXP,ISO)
SKF 38393  (ISO)
SKF-96365 hydrochloride  (EXP)
SM-164  (ISO)
SNX-2112  (ISO)
sodium acetate trihydrate  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP)
sodium benzoate  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium cholate  (ISO)
sodium chromate  (ISO)
sodium cyanate  (ISO)
sodium dichromate  (EXP,ISO)
sodium disulfite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium hydrogensulfite  (EXP)
sodium hydroxide  (EXP)
sodium iodide  (EXP)
sodium nitrite  (EXP)
sodium propionate  (ISO)
Sodium salicylate  (EXP,ISO)
sodium sulfite  (EXP)
sodium thiosulfate pentahydrate  (EXP)
solanesol  (ISO)
solasodine  (ISO)
Soman  (EXP)
Sophoricoside  (ISO)
sorafenib  (EXP,ISO)
sotorasib  (ISO)
SP2509  (ISO)
spermidine  (ISO)
spermine  (EXP,ISO)
spironolactone  (EXP,ISO)
Spiroquinazoline  (ISO)
Spiruchostatin A  (ISO)
spiruchostatin B  (ISO)
splitomicin  (ISO)
squalene  (EXP)
Squamocin  (ISO)
SR 144528  (ISO)
starch  (ISO)
staurosporine  (EXP,ISO)
stavudine  (ISO)
sterigmatocystin  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
strychnine  (EXP)
styrene oxide  (EXP,ISO)
succimer  (EXP)
sucrose  (ISO)
Suillin  (ISO)
sulfadimethoxine  (EXP)
sulfaphenazole  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sulpiride  (ISO)
sumatriptan  (EXP)
sunitinib  (EXP,ISO)
suramin  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
swainsonine  (EXP)
Swertiamarin  (ISO)
syringic acid  (EXP,ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (EXP)
taiwanin C  (ISO)
talazoparib  (ISO)
Talc  (ISO)
tamarixetin  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP,ISO)
tangeretin  (EXP,ISO)
tannic acid  (EXP)
Tanshinone I  (EXP,ISO)
tapentadol  (ISO)
taraxasterol  (ISO)
tartrazine  (EXP)
Tartrolon D  (ISO)
taurine  (EXP)
taurocholic acid  (EXP)
taurodeoxycholic acid  (ISO)
taurolithocholic acid sulfate  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
Tautomycin  (ISO)
tazarotene  (ISO)
tebuconazole  (EXP)
tellurium atom  (EXP)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
TEMPO  (EXP,ISO)
Temsirolimus  (EXP,ISO)
tenofovir disoproxil fumarate  (EXP)
teprenone  (ISO)
terbutaline  (ISO)
Terfenadine  (EXP,ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
tetracaine  (EXP)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachlorocatechol  (ISO)
tetrachloroethene  (ISO)
tetrachlorohydroquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrahydrocurcumin  (ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (EXP,ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
tetrazolium violet  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (EXP,ISO)
theaflavin  (EXP)
Theaflavin 3,3'-digallate  (EXP,ISO)
theophylline  (ISO)
thiabendazole  (EXP)
thiamethoxam  (ISO)
thiamine(1+) chloride  (EXP)
thiazoles  (ISO)
thimerosal  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiopental  (ISO)
thioridazine  (ISO)
thiosalicylic acid  (EXP)
Thiotepa  (ISO)
thiourea  (EXP,ISO)
Thrombin  (EXP)
thymidine  (ISO)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (EXP,ISO)
ticlopidine  (ISO)
tigecycline  (EXP)
tipifarnib  (ISO)
Tiron  (EXP,ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topiramate  (EXP)
topotecan  (ISO)
torin 1  (ISO)
Tormentic acid  (ISO)
Torularhodin  (ISO)
torulene  (ISO)
tramadol  (EXP,ISO)
trametinib  (ISO)
tranexamic acid  (ISO)
trans-anethole  (EXP)
trans-caffeic acid  (EXP,ISO)
trans-chalcone  (ISO)
trans-cinnamic acid  (EXP)
tranylcypromine  (EXP)
trenbolone  (EXP)
triacetin  (ISO)
triacsin C  (ISO)
triadimefon  (ISO)
triazoles  (ISO)
tributyl phosphate  (EXP)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (ISO)
tricetin  (ISO)
trichlorfon  (ISO)
trichloroacetic acid  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triciribine  (ISO)
triclosan  (ISO)
trifluoperazine  (EXP,ISO)
trifluridine  (ISO)
trilostane  (EXP)
trimellitic anhydride  (ISO)
trimethylamine N-oxide  (ISO)
trimethylarsine oxide  (EXP)
trimethylenediamine  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(picolinato)chromium  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tropisetron  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (EXP,ISO)
tyrphostin B42  (ISO)
U-73122  (ISO)
ubiquinones  (EXP,ISO)
umbelliferone  (EXP,ISO)
uranium atom  (EXP)
uridine  (ISO)
Urolithin A  (EXP,ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (EXP,ISO)
usnic acid  (ISO)
valinomycin  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
Valtratum  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
vandetanib  (ISO)
vanillic acid  (EXP)
vanillin  (EXP)
vemurafenib  (ISO)
venetoclax  (ISO)
venlafaxine hydrochloride  (EXP)
venom  (ISO)
verapamil  (EXP,ISO)
Vernodalin  (ISO)
Vernodalol  (ISO)
Vicanicin  (ISO)
vincaleukoblastine  (EXP,ISO)
vincristine  (EXP,ISO)
vinorelbine  (ISO)
Vinpocetine  (EXP)
vinyl carbamate  (ISO)
violacein  (ISO)
vismodegib  (ISO)
vitamin D  (ISO)
vitamin E  (EXP,ISO)
vitexin  (ISO)
vorinostat  (EXP,ISO)
vosaroxin  (ISO)
VX nerve agent  (EXP,ISO)
warfarin  (EXP,ISO)
water  (EXP)
wedelolactone  (EXP,ISO)
WIN 55212-2  (ISO)
withaferin A  (EXP,ISO)
wogonin  (EXP,ISO)
wortmannin  (EXP,ISO)
WP1066  (ISO)
xanthohumol  (EXP,ISO)
Xanthorrhizol  (ISO)
XAV939  (ISO)
XMU-MP-1  (ISO)
xylitol  (ISO)
Y-27632  (EXP,ISO)
yttrium chloride  (EXP)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc acetate  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc molecular entity  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zineb  (ISO)
zingerone  (EXP)
zingiberene  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
anterior neural tube closure  (ISO)
apoptotic process  (IBA,IEA,ISO)
axonal fasciculation  (IEA,IMP)
B cell homeostasis  (ISO)
cell fate commitment  (ISO)
cellular response to staurosporine  (IEA,ISO)
DNA damage response  (ISO)
erythrocyte differentiation  (IBA,IEA,ISO)
execution phase of apoptosis  (IBA,IEA,ISO)
glial cell apoptotic process  (IEP,ISO)
heart development  (ISO)
hippocampus development  (IEP)
intracellular signal transduction  (IMP)
intrinsic apoptotic signaling pathway  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to osmotic stress  (IEA,ISO)
keratinocyte differentiation  (IBA,ISO)
learning or memory  (IMP)
leukocyte apoptotic process  (IEP)
luteolysis  (IEP)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of cytokine production  (IEA,ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (IBA,IEP)
neurotrophin TRK receptor signaling pathway  (ISO)
positive regulation of amyloid-beta formation  (IDA,IEA,ISO)
positive regulation of apoptotic DNA fragmentation  (ISO)
positive regulation of apoptotic process  (IEA,IMP,ISO)
positive regulation of neuron apoptotic process  (IBA,IMP)
positive regulation of pyroptotic inflammatory response  (IEA,ISO)
protein catabolic process  (IDA,IEA,ISO)
protein maturation  (IEA,ISO)
protein processing  (IEA,ISO)
proteolysis  (IBA,IDA,IEA,ISO)
pyroptotic inflammatory response  (IEA,ISO)
regulation of neuron apoptotic process  (IEP)
regulation of protein stability  (IDA,IEA,ISO)
regulation of synaptic vesicle cycle  (IEA,ISO)
response to amino acid  (IEP)
response to anesthetic  (IEP)
response to auditory stimulus  (ISO)
response to cobalt ion  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to glucocorticoid  (IEP)
response to glucose  (IDA)
response to hydrogen peroxide  (IDA,IEA)
response to hypoxia  (IEP)
response to insulin-like growth factor stimulus  (IEP)
response to ionizing radiation  (IEA)
response to lipopolysaccharide  (IEP)
response to metal ion  (IEP)
response to nicotine  (IEP)
response to UV  (ISO)
response to wounding  (ISO)
response to X-ray  (IEP)
response to xenobiotic stimulus  (IEP)
sensory perception of sound  (ISO)
striated muscle cell differentiation  (IEP)
swimming behavior  (IEP)
T cell homeostasis  (ISO)

Cellular Component

References

References - curated
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4. Neutrophil gelatinase-associated lipocalin (NGAL) may play a protective role against rats ischemia/reperfusion renal injury via inhibiting tubular epithelial cell apoptosis. An S, etal., Ren Fail. 2013;35(1):143-9. doi: 10.3109/0886022X.2012.741877. Epub 2012 Nov 15.
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8. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
9. Inhibition of HtrA2/Omi ameliorates heart dysfunction following ischemia/reperfusion injury in rat heart in vivo. Bhuiyan MS and Fukunaga K, Eur J Pharmacol. 2007 Feb 28;557(2-3):168-77. Epub 2006 Nov 14.
10. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Bishayee A, etal., Int J Cancer. 2013 Sep 1;133(5):1054-63. doi: 10.1002/ijc.28108. Epub 2013 Mar 29.
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35. Leptin protects H9c2 rat cardiomyocytes from H(2)O(2)-induced apoptosis. Eguchi M, etal., FEBS J. 2008 Jun;275(12):3136-44. Epub 2008 May 8.
36. Effect of maternal diabetes and hypercholesterolemia on fetal liver of albino Wistar rats. El-Sayyad HI, etal., Nutrition. 2014 Mar;30(3):326-36. doi: 10.1016/j.nut.2013.08.016.
37. Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NF¿B, oxidative stress, and apoptosis. Elsherbiny NM, etal., Toxicol Mech Methods. 2018 Jul;28(6):467-473. doi: 10.1080/15376516.2018.1459995. Epub 2018 Apr 16.
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42. Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Flaws JA, etal., Endocrinology 1995 Nov;136(11):5042-53.
43. Histomorphometry and expression of Cdc47 and caspase-3 in hyperthyroid rat uteri and placentas during gestation and postpartum associated with fetal development. Freitas ES, etal., Reprod Fertil Dev. 2007;19(3):498-509.
44. Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease. Gaballah HH, etal., Chem Biol Interact. 2016 May 5;251:10-6. doi: 10.1016/j.cbi.2016.03.023. Epub 2016 Mar 22.
45. Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. Gali-Muhtasib H, etal., J Cell Mol Med. 2008 Jan-Feb;12(1):330-42. doi: 10.1111/j.1582-4934.2007.00095.x.
46. [Expression of VCAM-1 and caspase-3 in myocardium of persons who died from viral myocarditis]. Gao D, etal., Fa Yi Xue Za Zhi. 2013 Jun;29(3):161-3, 167.
47. Death of hypothalamic astrocytes in poorly controlled diabetic rats is associated with nuclear translocation of apoptosis inducing factor. Garcia-Caceres C, etal., J Neuroendocrinol. 2008 Dec;20(12):1348-60.
48. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
49. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Gervais FG, etal., Cell 1999 Apr 30;97(3):395-406.
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182. Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. Wei Y, etal., Mol Med Rep. 2018 Jan;17(1):1493-1498. doi: 10.3892/mmr.2017.8036. Epub 2017 Nov 13.
183. Testicular developmental impairment caused by flutamide-induced and DEHP-induced cryptorchid rat models is mediated by excessive apoptosis and deficient autophagy. Wei Y, etal., Toxicol Mech Methods. 2018 Sep;28(7):507-519. doi: 10.1080/15376516.2018.1459994. Epub 2018 Jun 5.
184. Evaluation of apoptotic pathways in dorsal root ganglion neurons following peripheral nerve injury. Wiberg R, etal., Neuroreport. 2018 Jun 13;29(9):779-785. doi: 10.1097/WNR.0000000000001031.
185. The protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with SAP. Xiping Z, etal., Mediators Inflamm. 2007;2007:19469.
186. Protecting effects of dexamethasone on thymus of rats with severe acute pancreatitis. Xiping Z, etal., Mediators Inflamm. 2007;2007:72361.
187. XZ-1 regulates cell apoptosis of gastric epithelial dysplasia via NF-¿B/p53/Ki67 signaling pathway. Xu B, etal., Biosci Rep. 2018 Jun 12;38(3). pii: BSR20171529. doi: 10.1042/BSR20171529. Print 2018 Jun 29.
188. Glutamate-induced losses of oligodendrocytes and neurons and activation of caspase-3 in the rat spinal cord. Xu GY, etal., Neuroscience. 2008 Mar 7;.
189. Bajijiasu Ameliorates ß-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. Xu TT, etal., Cell Physiol Biochem. 2018;46(1):107-117. doi: 10.1159/000488414. Epub 2018 Mar 20.
190. Neuroprotective Effects of Loganin on MPTP-Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies. Xu YD, etal., J Cell Biochem. 2017 Oct;118(10):3495-3510. doi: 10.1002/jcb.26010. Epub 2017 May 16.
191. Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis. Yacobi K, etal., Endocrinology. 2007 Apr;148(4):1717-26. Epub 2007 Jan 11.
192. Potential neuroprotective effect of gamma-glutamylcysteine ethyl ester on rat brain against kainic acid-induced excitotoxicity. Yalcin A, etal., Free Radic Res. 2010 May;44(5):513-21. doi: 10.3109/10715761003645964.
193. Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs. Yan X, etal., J Ethnopharmacol. 2018 May 8;227:105-112. doi: 10.1016/j.jep.2018.05.006.
194. Activation of caspase-12 at early stage contributes to cardiomyocyte apoptosis in trauma-induced secondary cardiac injury. Yan Z, etal., Sheng Li Xue Bao. 2017 Aug 25;69(4):367-377.
195. Effects of Lignans from Schisandra chinensis Rattan Stems against Aß1-42-Induced Memory Impairment in Rats and Neurotoxicity in Primary Neuronal Cells. Yang BY, etal., Molecules. 2018 Apr 10;23(4). pii: molecules23040870. doi: 10.3390/molecules23040870.
196. Protection effect of survivin protein overexpression on acute myocardial infarction in rats. Yang M, etal., Int J Clin Exp Med. 2015 Aug 15;8(8):12995-3000. eCollection 2015.
197. Tumor necrosis factor-a mediates JNK activation response to intestinal ischemia-reperfusion injury. Yang Q, etal., World J Gastroenterol. 2013 Aug 14;19(30):4925-34. doi: 10.3748/wjg.v19.i30.4925.
198. MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1. Yang S, etal., J Cell Biochem. 2019 Mar;120(3):3813-3821. doi: 10.1002/jcb.27663. Epub 2018 Sep 27.
199. Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents. Yang X-, etal., J Mol Neurosci. 2017 Mar;61(3):368-378. doi: 10.1007/s12031-016-0866-9. Epub 2016 Dec 6.
200. Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats. Yang Y, etal., Reprod Sci. 2015 May;22(5):572-84. doi: 10.1177/1933719114553445. Epub 2014 Oct 20.
201. Protective effect of curcumin on chemotherapy-induced intestinal dysfunction. Yao Q, etal., Int J Clin Exp Pathol. 2013 Oct 15;6(11):2342-9. eCollection 2013.
202. Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer. Ye Y, etal., Tumour Biol. 2016 Mar;37(3):3185-95. doi: 10.1007/s13277-015-4100-0. Epub 2015 Oct 2.
203. Time course of apoptosis induced by photodynamic therapy with PsD007 in LT12 acute myeloid leukemia cells. Yin H, etal., Lasers Med Sci. 2016 Jul;31(5):817-24. doi: 10.1007/s10103-016-1887-x. Epub 2016 Feb 9.
204. Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1alpha and p53 pathways. Yin R, etal., Respir Physiol Neurobiol. 2016 Jan;220:81-7. doi: 10.1016/j.resp.2015.09.011. Epub 2015 Sep 30.
205. The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia. Yip KK, etal., Neuroscience. 2011 Sep 8;190:301-6. doi: 10.1016/j.neuroscience.2011.06.022. Epub 2011 Jun 17.
206. Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation. Yoo KC, etal., Int J Nanomedicine. 2012;7:1203-14. doi: 10.2147/IJN.S28647. Epub 2012 Mar 5.
207. Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer. Yu X, etal., J Exp Clin Cancer Res. 2020 Apr 10;39(1):62. doi: 10.1186/s13046-020-01566-2.
208. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
209. Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage: an experimental and immunohistochemical study. Yumusak N, etal., Nucl Med Commun. 2018 Feb;39(2):131-139. doi: 10.1097/MNM.0000000000000788.
210. Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. Zeng C, etal., PLoS One. 2018 Mar 14;13(3):e0193845. doi: 10.1371/journal.pone.0193845. eCollection 2018.
211. Inhibiting caspase-3 activity blocks beta-catenin degradation after focal ischemia in rat. Zhang H, etal., Neuroreport. 2008 May 28;19(8):821-4.
212. Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways. Zhang HB, etal., Brain Inj. 2017;31(3):406-415. doi: 10.1080/02699052.2016.1225984. Epub 2017 Jan 31.
213. H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation. Zhang X, etal., Cell Physiol Biochem. 2017;43(4):1311-1324. doi: 10.1159/000481843. Epub 2017 Oct 9.
214. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. Zhang X, etal., J Biol Chem 2003 Jan 10;278(2):1248-58.
215. Astragalus mongholicus (Fisch.) Bge Improves Peripheral Treg Cell Immunity Imbalance in the Children With Viral Myocarditis by Reducing the Levels of miR-146b and miR-155. Zhang Z, etal., Front Pediatr. 2018 Jun 21;6:139. doi: 10.3389/fped.2018.00139. eCollection 2018.
216. Amyloid oligomers in diabetic and nondiabetic human pancreas. Zhao HL, etal., Transl Res. 2009 Jan;153(1):24-32. Epub 2008 Nov 19.
217. Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. Zhong C, etal., Oncotarget. 2017 Apr 10;8(33):54187-54198. doi: 10.18632/oncotarget.17018. eCollection 2017 Aug 15.
Additional References at PubMed
PMID:8689682   PMID:8761296   PMID:9030616   PMID:9353287   PMID:9512515   PMID:9796814   PMID:10479688   PMID:10618441   PMID:10921886   PMID:11092819   PMID:11350920   PMID:11374883  
PMID:11549719   PMID:11913980   PMID:11919513   PMID:12112012   PMID:12124386   PMID:12393932   PMID:12427836   PMID:12435619   PMID:12477715   PMID:12491792   PMID:12535938   PMID:12606450  
PMID:12689601   PMID:12724284   PMID:12775421   PMID:12847083   PMID:12888622   PMID:12949912   PMID:12954857   PMID:12970760   PMID:12975376   PMID:13679151   PMID:14507967   PMID:14561754  
PMID:14602082   PMID:14657025   PMID:14732288   PMID:14739302   PMID:15024023   PMID:15068794   PMID:15075310   PMID:15093730   PMID:15149850   PMID:15231831   PMID:15316934   PMID:15351510  
PMID:15456877   PMID:15456943   PMID:15487762   PMID:15489334   PMID:15563579   PMID:15565177   PMID:15578657   PMID:15623433   PMID:15663790   PMID:15755684   PMID:15843901   PMID:15906374  
PMID:16004991   PMID:16112714   PMID:16123172   PMID:16183742   PMID:16221205   PMID:16226814   PMID:16328956   PMID:16351572   PMID:16356733   PMID:16361258   PMID:16427076   PMID:16469926  
PMID:16499868   PMID:16679645   PMID:16714296   PMID:16800886   PMID:16920334   PMID:16937528   PMID:16985504   PMID:17080656   PMID:17101276   PMID:17124493   PMID:17167422   PMID:17179255  
PMID:17324936   PMID:17357523   PMID:17363452   PMID:17367932   PMID:17431085   PMID:17441317   PMID:17475835   PMID:17487878   PMID:17542038   PMID:17544522   PMID:17559062   PMID:17564836  
PMID:17698050   PMID:17712625   PMID:17823127   PMID:17899337   PMID:17901126   PMID:17996851   PMID:18030677   PMID:18041091   PMID:18056966   PMID:18057239   PMID:18070754   PMID:18156166  
PMID:18157632   PMID:18225740   PMID:18250162   PMID:18337831   PMID:18338260   PMID:18396777   PMID:18420950   PMID:18704645   PMID:18931307   PMID:18989778   PMID:18991865   PMID:19035263  
PMID:19099715   PMID:19148780   PMID:19162106   PMID:19193634   PMID:19234092   PMID:19240112   PMID:19379782   PMID:19411116   PMID:19415683   PMID:19467786   PMID:19548559   PMID:19596402  
PMID:19621461   PMID:19629696   PMID:19696229   PMID:19696693   PMID:19713428   PMID:19740745   PMID:19759058   PMID:19815060   PMID:19837873   PMID:19837952   PMID:19844237   PMID:19861275  
PMID:19909801   PMID:19936637   PMID:19969310   PMID:20137712   PMID:20155328   PMID:20203072   PMID:20369315   PMID:20448356   PMID:20529819   PMID:20564462   PMID:20575418   PMID:20681308  
PMID:20840861   PMID:21038679   PMID:21097400   PMID:21126425   PMID:21144461   PMID:21166152   PMID:21216952   PMID:21245950   PMID:21251262   PMID:21477647   PMID:21515572   PMID:21570442  
PMID:21656845   PMID:21660956   PMID:21674244   PMID:21681347   PMID:21716255   PMID:21726810   PMID:21730107   PMID:21756776   PMID:21827835   PMID:21856377   PMID:21858143   PMID:21914039  
PMID:21980415   PMID:21996423   PMID:22119805   PMID:22127415   PMID:22194118   PMID:22253444   PMID:22282255   PMID:22305649   PMID:22316545   PMID:22358842   PMID:22446191   PMID:22446192  
PMID:22526145   PMID:22544840   PMID:22559303   PMID:22613773   PMID:22641427   PMID:22717287   PMID:22819929   PMID:22870319   PMID:22883038   PMID:22942730   PMID:22959929   PMID:22963862  
PMID:22975163   PMID:22978712   PMID:23054679   PMID:23089979   PMID:23099040   PMID:23119112   PMID:23151725   PMID:23220262   PMID:23313858   PMID:23471945   PMID:23523151   PMID:23727203  
PMID:23729654   PMID:23792135   PMID:23861879   PMID:23940672   PMID:23949220   PMID:23954828   PMID:24023391   PMID:24091940   PMID:24101493   PMID:24372803   PMID:24378336   PMID:24518793  
PMID:24633814   PMID:24688304   PMID:24787014   PMID:24803807   PMID:24863870   PMID:24917042   PMID:25113058   PMID:25139234   PMID:25270371   PMID:25439027   PMID:25519685   PMID:26012958  
PMID:26047381   PMID:26125843   PMID:26271974   PMID:26456506   PMID:26806574   PMID:26818429   PMID:26983277   PMID:27220977   PMID:27239756   PMID:27310873   PMID:27320597   PMID:27412936  
PMID:27472881   PMID:27622324   PMID:27645924   PMID:27769787   PMID:27802439   PMID:27830683   PMID:27919736   PMID:27998213   PMID:28002813   PMID:28040459   PMID:28266775   PMID:28383560  
PMID:28447745   PMID:28555276   PMID:28601953   PMID:28637381   PMID:28951616   PMID:29398472   PMID:29568969   PMID:29901224   PMID:30322151   PMID:30488170   PMID:30703413   PMID:30769782  
PMID:30920066   PMID:30949500   PMID:31288583   PMID:31392537   PMID:31401888   PMID:31583941   PMID:31707369   PMID:32385548   PMID:32633389   PMID:32964031   PMID:33224431   PMID:33668863  
PMID:33710703   PMID:33744763   PMID:33856081   PMID:34552687   PMID:34729793   PMID:34890049   PMID:34979196   PMID:37531918   PMID:37729139   PMID:37938347   PMID:37955688   PMID:38254051  
PMID:38375595   PMID:38396011  


Genomics

Comparative Map Data
Casp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,395,539 - 52,413,794 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1652,395,540 - 52,413,732 (-)EnsemblGRCr8
mRatBN7.21645,662,910 - 45,681,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1645,662,910 - 45,684,648 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1651,061,544 - 51,079,742 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01654,429,112 - 54,447,305 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01649,700,916 - 49,719,114 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01648,845,011 - 48,863,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,845,012 - 48,863,204 (-)Ensemblrn6Rnor6.0
Rnor_5.01648,560,090 - 48,578,325 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41648,944,226 - 48,962,420 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1643,665,975 - 43,684,168 (-)NCBICelera
RGSC_v3.11648,944,301 - 48,962,495 (-)NCBI
Cytogenetic Map16q11NCBI
CASP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384184,627,696 - 184,649,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4184,627,695 - 184,650,418 (-)Ensemblhg38GRCh38
GRCh374185,548,850 - 185,570,601 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364185,785,844 - 185,807,623 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344185,923,999 - 185,945,750NCBI
Celera4182,877,510 - 182,899,293 (-)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4181,303,305 - 181,324,956 (-)NCBIHuRef
CHM1_14185,525,377 - 185,547,156 (-)NCBICHM1_1
T2T-CHM13v2.04187,971,378 - 187,993,131 (-)NCBIT2T-CHM13v2.0
Casp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39847,070,326 - 47,092,733 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl847,070,326 - 47,092,724 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38846,617,291 - 46,639,698 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl846,617,291 - 46,639,689 (+)Ensemblmm10GRCm38
MGSCv37847,702,803 - 47,724,071 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36848,116,266 - 48,137,534 (+)NCBIMGSCv36mm8
Celera849,300,031 - 49,321,270 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.39NCBI
Casp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540324,315,727 - 24,324,732 (+)Ensembl
ChiLan1.0NW_00495540324,315,712 - 24,326,271 (+)NCBIChiLan1.0ChiLan1.0
CASP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23182,351,669 - 182,373,528 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14182,713,461 - 182,735,319 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04176,793,190 - 176,815,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14189,018,422 - 189,040,217 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4189,018,422 - 189,040,185 (-)EnsemblpanPan2panpan1.1
CASP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11645,920,074 - 45,940,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1645,920,071 - 45,940,505 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1646,413,238 - 46,434,538 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01648,136,012 - 48,157,278 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1648,135,662 - 48,157,268 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11646,101,180 - 46,122,422 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01646,715,535 - 46,736,806 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01646,848,704 - 46,870,015 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Casp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494333,516,817 - 33,538,924 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365544,571,109 - 4,593,740 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365544,571,072 - 4,593,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1545,742,751 - 45,764,213 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11545,744,320 - 45,753,252 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21552,291,074 - 52,299,625 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17130,589,592 - 130,610,845 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7130,591,166 - 130,610,899 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037110,841,187 - 110,862,527 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11341,290,923 - 41,309,762 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Casp3
87 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:139
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000014095
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164975766656898388Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat

Markers in Region
RH133488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21645,663,076 - 45,663,267 (+)MAPPERmRatBN7.2
Rnor_6.01648,845,178 - 48,845,368NCBIRnor6.0
Rnor_5.01648,560,257 - 48,560,447UniSTSRnor5.0
RGSC_v3.41648,944,393 - 48,944,583UniSTSRGSC3.4
Celera1643,666,142 - 43,666,332UniSTS
Cytogenetic Map16q11UniSTS
PMC148819P9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21645,664,509 - 45,664,701 (+)MAPPERmRatBN7.2
Rnor_6.01648,846,611 - 48,846,802NCBIRnor6.0
Rnor_5.01648,561,690 - 48,561,881UniSTSRnor5.0
RGSC_v3.41648,945,826 - 48,946,017UniSTSRGSC3.4
Celera1643,667,575 - 43,667,766UniSTS
Cytogenetic Map16q11UniSTS
Casp3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1643,669,226 - 43,670,099UniSTS
Celera533,605,508 - 33,605,721UniSTS
Cytogenetic Map1q12UniSTS
Cytogenetic Map16q11UniSTS


Related Rat Strains
The following Strains have been annotated to Casp3
F344-Tg(NC1-269B17)1Nkg     F344-Tg(NC1-269B17)2Nkg     F344-Tg(NC1-269B17)3Nkg     F344-Tg(NC1-269B17)4Nkg    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014095   ⟹   ENSRNOP00000014096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1652,395,540 - 52,413,732 (-)Ensembl
mRatBN7.2 Ensembl1645,662,910 - 45,684,648 (-)Ensembl
Rnor_6.0 Ensembl1648,845,012 - 48,863,204 (-)Ensembl
RefSeq Acc Id: NM_012922   ⟹   NP_037054
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,395,539 - 52,413,732 (-)NCBI
mRatBN7.21645,662,910 - 45,681,103 (-)NCBI
Rnor_6.01648,845,011 - 48,863,204 (-)NCBI
Rnor_5.01648,560,090 - 48,578,325 (-)NCBI
RGSC_v3.41648,944,226 - 48,962,420 (-)RGD
Celera1643,665,975 - 43,684,168 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253130   ⟹   XP_006253192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,395,539 - 52,413,794 (-)NCBI
mRatBN7.21645,662,910 - 45,681,171 (-)NCBI
Rnor_6.01648,845,011 - 48,863,249 (-)NCBI
Rnor_5.01648,560,090 - 48,578,325 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094205   ⟹   XP_038950133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,397,355 - 52,413,794 (-)NCBI
mRatBN7.21645,664,730 - 45,681,165 (-)NCBI
RefSeq Acc Id: NP_037054   ⟸   NM_012922
- UniProtKB: P97699 (UniProtKB/Swiss-Prot),   P70543 (UniProtKB/Swiss-Prot),   Q62993 (UniProtKB/Swiss-Prot),   P55213 (UniProtKB/Swiss-Prot),   A6JPM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253192   ⟸   XM_006253130
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000014096   ⟸   ENSRNOT00000014095
RefSeq Acc Id: XP_038950133   ⟸   XM_039094205
- Peptide Label: isoform X2
Protein Domains
Caspase family p10   Caspase family p20

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55213-F1-model_v2 AlphaFold P55213 1-277 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700095
Promoter ID:EPDNEW_R10619
Type:initiation region
Name:Casp3_1
Description:caspase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01648,863,191 - 48,863,251EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2275 AgrOrtholog
BioCyc Gene G2FUF-11360 BioCyc
Ensembl Genes ENSRNOG00000010475 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014095 ENTREZGENE
  ENSRNOT00000014095.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1460 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7104685 IMAGE-MGC_LOAD
InterPro Caspase-like_dom_sf UniProtKB/Swiss-Prot
  Caspase_cys_AS UniProtKB/Swiss-Prot
  Caspase_his_AS UniProtKB/Swiss-Prot
  Pept_C14 UniProtKB/Swiss-Prot
  Pept_C14_caspase UniProtKB/Swiss-Prot
  Pept_C14_p10 UniProtKB/Swiss-Prot
  Pept_C14_p20 UniProtKB/Swiss-Prot
  Pept_C14A UniProtKB/Swiss-Prot
KEGG Report rno:25402 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93645 IMAGE-MGC_LOAD
NCBI Gene 25402 ENTREZGENE
PANTHER CASPASE-3 UniProtKB/Swiss-Prot
  PTHR10454 UniProtKB/Swiss-Prot
Pfam Peptidase_C14 UniProtKB/Swiss-Prot
PharmGKB CASP3 RGD
PhenoGen Casp3 PhenoGen
PRINTS IL1BCENZYME UniProtKB/Swiss-Prot
PROSITE CASPASE_CYS UniProtKB/Swiss-Prot
  CASPASE_HIS UniProtKB/Swiss-Prot
  CASPASE_P10 UniProtKB/Swiss-Prot
  CASPASE_P20 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010475 RatGTEx
SMART CASc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52129 UniProtKB/Swiss-Prot
UniProt A6JPM8_RAT UniProtKB/TrEMBL
  A6JPM9 ENTREZGENE, UniProtKB/TrEMBL
  A6JPN0_RAT UniProtKB/TrEMBL
  CASP3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70543 ENTREZGENE
  P97699 ENTREZGENE
  Q62993 ENTREZGENE
UniProt Secondary P70543 UniProtKB/Swiss-Prot
  P97699 UniProtKB/Swiss-Prot
  Q62993 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-05 Casp3  caspase 3  Casp3  caspase 3, apoptosis related cysteine protease  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Casp3  caspase 3, apoptosis related cysteine protease      Name updated 1299863 APPROVED
2002-11-06 Casp3  caspase 3    Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease)  Name updated 625702 APPROVED
2002-06-10 Casp3  Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease plays a major role in brain injury leading to hypoxia-ischemia in developing brain 625571
gene_drugs after neonatal hypoxia-ischemia activity is reversibly inhibited by M826, resulting in neuroprotection 625571
gene_drugs activity blocked by z-DEVD-fmk 628545
gene_drugs M826 (ICV injection of 30nmol) is a selective reversible inhibitor of the caspase activity after neonatal hypoxia-ischemia, it cleaves all the substrates resulting in neuroprotection 628545
gene_function cysteine-aspartic acid protease (caspase) 628545
gene_process responsible for delayed-neuronal cell death 625571
gene_process brings about calpain activation involved in excitotoxic/necrotic cell death 625571
gene_process brings about calpain activation involved in excitotoxic/necrotic cell death 628545
gene_process active in later stages of apoptosis; cleaves and activates caspases 6,7 and 9 628545
gene_process plays a role in neural protection 634699
gene_process plays a role in carbon monoxide inhibition of apoptosis 634700
gene_product member of the caspase family 625571
gene_regulation activated by cholecystokinin (CCK) in pancreatic acinar cells 625521
gene_regulation activated during Tnf alpha mediated cell death in vascular smooth muscle cells 628545
gene_regulation protein kinase C phosphorylation decreases ability to bind to epsilon protein kinase C 69798