GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | increases activity | EXP | | 6480464 | CTD | hydroquinone results in increased activity of CASP3 protein | PMID:26056850 | Casp3 | decreases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | hydroquinone results in decreased activity of CASP3 protein | PMID:22960397 | Casp3 | decreases expression | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | hydroquinone results in decreased expression of CASP3 mRNA; hydroquinone results in decreased expression of CASP3 protein | PMID:15452088 PMID:27515134 PMID:28983606 | Casp3 | increases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | hydroquinone results in increased activity of CASP3 protein | PMID:15816534 PMID:20946948 PMID:23776099 | Casp3 | increases cleavage | ISO | Casp3 (Mus musculus) | 6480464 | CTD | hydroquinone results in increased cleavage of CASP3 protein | PMID:27606422 | Casp3 | increases cleavage | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | hydroquinone results in increased cleavage of CASP3 protein | PMID:15777082 PMID:22302391 PMID:23288922 PMID:24053669 PMID:26335980 PMID:35123993 | Casp3 | increases degradation | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | hydroquinone results in increased degradation of CASP3 protein | PMID:35302183 | Casp3 | increases expression | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | hydroquinone results in increased expression of CASP3 protein modified form | PMID:28886972 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | [hydroquinone results in increased abundance of Reactive Oxygen Species] which results in decreased activity of CASP3 protein | PMID:15337166 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [hydroquinone results in increased cleavage of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [hydroquinone results in increased cleavage of CASP3 protein]; [PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of and affects the activity of CASP3 protein; Acetylcysteine inhibits the reaction [hydroquinone results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased cleavage of CASP3 protein]; FADD protein affects the reaction [hydroquinone results in increased cleavage of CASP3 protein]; hydroquinone results in decreased expression of and results in increased cleavage of CASP3 protein; IGF1 protein inhibits the reaction [hydroquinone results in increased expression of CASP3 protein modified form]; Lithium Chloride inhibits the reaction [hydroquinone results in increased expression of CASP3 protein modified form]; NOX4 protein promotes the reaction [hydroquinone results in increased degradation of CASP3 protein]; Okadaic Acid inhibits the reaction [hydroquinone results in increased cleavage of CASP3 protein]; PARP1 protein affects the reaction [hydroquinone results in increased cleavage of CASP3 protein] | PMID:15816534 PMID:23288922 PMID:26335980 PMID:28444915 PMID:28886972 PMID:35123993 PMID:35302183 PMID:37148176 | | ||||||||||||||||||||||
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