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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:3215
Term: bupivacaine
Definition: A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Chemical ID: MESH:D002045
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDBupivacaine results in increased activity of CASP3 proteinPMID:16109997
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDBupivacaine results in decreased expression of CASP3 proteinPMID:20194319
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