GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | decreases expression | EXP | | 6480464 | CTD | cobaltous chloride results in decreased expression of CASP3 protein | PMID:29155206 | Casp3 | increases activity | EXP | | 6480464 | CTD | cobaltous chloride results in increased activity of CASP3 protein | PMID:11078377 PMID:18442013 PMID:19156866 PMID:21804221 PMID:21998720 | Casp3 | increases expression | EXP | | 6480464 | CTD | cobaltous chloride results in increased expression of CASP3 protein; cobaltous chloride results in increased expression of CASP3 protein modified form | PMID:19520152 PMID:21925238 PMID:30551423 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | 4-phenylbutyric acid inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; [acetyl-aspartyl-glutamyl-valyl-aspartal results in decreased activity of CASP3 protein] which results in decreased susceptibility to cobaltous chloride; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased cleavage of and results in increased activity of CASP3 protein]; cobaltous chloride results in increased cleavage of and results in increased activity of CASP3 protein; DDAH2 protein promotes the reaction [Tretinoin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]]; Plant Extracts inhibits the reaction [cobaltous chloride results in increased expression of CASP3 protein]; Protein Kinase Inhibitors inhibits the reaction [cobaltous chloride results in increased expression of CASP3 protein modified form]; SB 203580 inhibits the reaction [cobaltous chloride results in increased cleavage of and results in increased activity of CASP3 protein]; scutellarin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; sodium bisulfide inhibits the reaction [cobaltous chloride results in increased cleavage of and results in increased activity of CASP3 protein]; Tretinoin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [cobaltous chloride results in increased cleavage of and results in increased activity of CASP3 protein] | PMID:11891799 PMID:18442013 PMID:19156866 PMID:21804221 PMID:21925238 PMID:21998720 PMID:30551423 | Casp3 | increases activity | ISO | Casp3 (Mus musculus) | 6480464 | CTD | cobaltous chloride results in increased activity of CASP3 protein | PMID:23251428 PMID:24412703 | Casp3 | increases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | cobaltous chloride results in increased activity of CASP3 protein | PMID:16374551 PMID:21687937 PMID:23326189 PMID:24386346 PMID:25125499 | Casp3 | increases cleavage | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | cobaltous chloride results in increased cleavage of CASP3 protein | PMID:22172632 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [POMC protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein]]; lysophosphatidic acid analog inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; lysophosphatidic acid inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; POMC protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein] | PMID:23251428 PMID:24412703 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | [3-methyladenine co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; [bafilomycin A1 co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; [cobaltous chloride affects the localization of CDKN1A protein] which results in increased expression of and results in increased stability of CASP3 protein; [cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; cobaltous chloride inhibits the reaction [Cyclosporine results in increased cleavage of and results in increased activity of CASP3 protein]; cobaltous chloride inhibits the reaction [Gentamicins results in increased cleavage of and results in increased activity of CASP3 protein]; cobaltous chloride promotes the reaction [nickel chloride results in increased cleavage of CASP3 protein]; cobaltous chloride results in increased expression of and results in increased activity of CASP3 protein; cobaltous chloride results in increased expression of and results in increased stability of CASP3 protein; ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; nickel chloride promotes the reaction [cobaltous chloride results in increased cleavage of CASP3 protein]; TP53 protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein] | PMID:14741615 PMID:20974702 PMID:21687937 PMID:22172632 PMID:22343435 PMID:23145036 PMID:23380477 PMID:24386346 PMID:25125499 | | ||||||||||||||||||||||
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