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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:34211
Term: 2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
Definition: A diarylmethane that has formula C14H8Cl4.
Chemical ID: MESH:C054919
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISOCasp3 (Mus musculus)6480464CTD2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 proteinPMID:26563996 PMID:32721735
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDATG7 protein affects the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]; BECN1 protein affects the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]; diazepinylbenzoic acid inhibits the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]; ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate inhibits the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]; RXRA mRNA promotes the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]; RXRB mRNA promotes the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]PMID:26563996 PMID:32721735
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