View Ontology Report


Nanoparticles (NP) are increasingly being in used in a wide range of applications, including biomedical and environmental. The potential hazard they may present is the focus of current nanotoxicology research. Among the nanoparticles with a broad spectrum of applications and known cellular responses are the carbon nanotubes, nano-titanium dioxide (TiO2) and nano-cerium oxide. TiO2 is a widely used pigment found in many consumer products that include cosmetics and sunscreens

Pathway Diagram:

Ariadne Genomics Inc. titanium dioxide nanoparticle --+> p53 signaling pathway titanium dioxide nanoparticle --+> FasL mediated signaling pathway 3N(O) ---- anatase 2P ---- anatase titanium dioxide nanoparticle ---> neutrophilia titanium dioxide nanoparticle ---> Lung Injury 3N(O) neutrophilia cytotoxicity genotoxicity Lung Injury brookite anatase rutile photocatalysis, under UV pigment titanium dioxide nanoparticle ---> cosmetics titanium dioxide nanoparticle ---> sunscreen titanium dioxide nanoparticle ---> prosthetic implants titanium dioxide nanoparticle ---> pigment cosmetics sunscreen prosthetic implants Bax Casp3 titanium dioxide nanoparticle ---> cytotoxicity mitochondrial function 2P anatase ---> photocatalysis, under UV titanium dioxide nanoparticle titanium dioxide nanoparticle --+> intrinsic apoptotic pathway Casp8 Fas Tp53 p53 signaling pathway Tlr4 titanium dioxide nanoparticle --+> Toll-like receptor signaling pathway intrinsic apoptotic pathway FasL mediated signaling pathway titanium dioxide nanoparticle ---| mitochondrial function titanium dioxide nanoparticle ---> genotoxicity Toll-like receptor signaling pathway

Genes in Pathway:

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titanium dioxide nanoparticle response pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:7248687
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:7248687
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:7248688
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:7248688
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:7248686
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:7248687

Pathway Gene Annotations

Disease Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway
Disease TermsGene Symbols
Acanthamoeba KeratitisTlr4
Acne ConglobataTlr4
Acne VulgarisTlr4
Acute Coronary SyndromeTlr4
Acute Kidney InjuryBax , Fas , Tlr4 , Tp53
Acute Lung InjuryBax , Fas , Tlr4
Acute Tubulointerstitial NephritisTlr4
Acute-On-Chronic Liver FailureTlr4
AdenocarcinomaCasp8 , Tp53
Adenocarcinoma of EsophagusFas , Tlr4 , Tp53
Adenocarcinoma of LungTp53
Adenocarcinoma, Bronchiolo-AlveolarTp53
Adenocarcinoma, Clear CellTp53
Adenocarcinoma, ColorectalTp53
Adenocarcinoma, ProstaticTp53
adrenal carcinomaTp53
Adrenal Gland NeoplasmsTp53
Adrenal InsufficiencyBax
Adrenocortical CarcinomaTp53
Adrenocortical Carcinoma, HereditaryTp53
Adrenocortical Carcinoma, PediatricTp53
Aging, PrematureBax , Tp53
Alzheimer DiseaseBax , Casp3 , Fas , Tlr4 , Tp53
Amoebiasis due to Entamoeba HistolyticaTlr4
Amyotrophic Lateral SclerosisCasp3 , Tp53
Anemia, AplasticFas
Angina, StableTlr4
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas
Aortic Aneurysm, ThoracicFas
Arsenic PoisoningTp53
Arthritis, ExperimentalBax
Arthritis, RheumatoidFas
AsthmaFas , Tlr4
Autoimmune DiseasesCasp8 , Fas
Autoimmune Lymphoproliferative SyndromeCasp8 , Fas
Autoimmune Lymphoproliferative Syndrome, Type IAFas
Bacterial InfectionsCasp3 , Casp8
Bacterial KeratitisTlr4
Balkan NephropathyTp53
Barrett EsophagusFas
Behcet SyndromeFas , Tlr4
bladder urothelial carcinomaTp53
Bone Diseases, DevelopmentalTp53
Bone Marrow NeoplasmsTp53
Brain Diseases, MetabolicFas
Brain InjuriesBax , Casp3 , Casp8 , Fas , Tlr4
Brain IschemiaCasp3 , Fas , Tlr4 , Tp53
Brain NeoplasmsTp53
Breast AdenocarcinomaTp53
breast cancerTp53
Breast NeoplasmsBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Bronchial HyperreactivityTlr4
Bronchiolitis, ViralTlr4
BurnsBax , Casp3
CarcinomaTlr4 , Tp53
Carcinoma, Adenoid CysticTp53
Carcinoma, Basal CellTp53
Carcinoma, HepatocellularCasp8 , Tlr4 , Tp53
Carcinoma, Intraductal, NoninfiltratingTp53
Carcinoma, Non-Small-Cell LungCasp3 , Casp8 , Tp53
Carcinoma, Renal CellCasp3 , Fas , Tp53
Carcinoma, Small CellTp53
Carcinoma, Squamous CellFas , Tp53
Carcinoma, Squamous Cell of Head and NeckCasp8 , Tp53
Carcinoma, Transitional CellCasp3 , Fas , Tp53
CardiomyopathiesFas , Tp53
Cardiomyopathy, DilatedBax , Fas
Cardiomyopathy, HypertrophicCasp3 , Tp53
Carotid Artery DiseasesTlr4 , Tp53
Carotid StenosisTlr4
CataractFas , Tp53
Cecal NeoplasmsTp53
Cell Transformation, NeoplasticTp53
Central Nervous System NeoplasmsTp53
Cerebral HemorrhageBax , Casp3 , Casp8
cervical cancerTp53
Chemical and Drug Induced Liver InjuryBax , Casp8 , Fas
Chemotherapy-Induced Febrile NeutropeniaTp53
Chest TraumaFas
Cholesteatoma, Middle EarTlr4 , Tp53
Choroid Plexus CarcinomaTp53
Chromosome 17 DeletionTp53
Chronic Lymphoid LeukemiaTp53
Chronic PainTlr4
Chronic PeriodontitisTlr4
Chronic UveitisFas
Colitis, ExperimentalFas
Colitis, UlcerativeTp53
colon cancerBax , Tp53
Colonic NeoplasmsBax , Casp3 , Fas , Tp53
colorectal cancerBax , Tp53
Colorectal NeoplasmsBax , Casp8 , Tlr4 , Tp53
Conjunctivitis, AllergicTlr4
Conjunctivitis, ChronicFas
Copper-Overload CirrhosisCasp3
Corneal NeovascularizationFas
Coronary Artery DiseaseTlr4
Coronary RestenosisTp53
Craniofacial AbnormalitiesTp53
Crohn DiseaseTlr4
Cystadenocarcinoma, SerousTp53
Cystic FibrosisFas , Tlr4
Dementia, Multi-InfarctBax
Dementia, VascularTp53
Demyelinating DiseasesTp53
Depressive DisorderBax
Dermatitis, Allergic ContactCasp8 , Tlr4
Dermatitis, AtopicTlr4
Dermatitis, ContactCasp8 , Tlr4
DermatomyositisFas , Tlr4
Diabetes MellitusTlr4
Diabetes Mellitus, ExperimentalBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Diabetes Mellitus, Type 1Casp3 , Casp8 , Fas , Tlr4
Diabetes Mellitus, Type 2Bax , Casp3 , Casp8 , Fas , Tlr4
Diabetic AngiopathiesCasp3 , Fas
Diabetic FootTlr4
Diabetic NephropathiesCasp3 , Fas , Tlr4 , Tp53
Diabetic NeuropathiesCasp3 , Tlr4
Diabetic RetinopathyCasp3 , Tlr4
Disease Models, AnimalFas , Tp53
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
Dry Eye SyndromesTlr4
Dyskeratosis Congenita, Autosomal RecessiveTp53
EdemaCasp3 , Casp8
Encephalitis, Herpes SimplexTlr4
Encephalomyelitis, Autoimmune, ExperimentalCasp3 , Casp8 , Tlr4
Endometrial NeoplasmsTp53
EndotoxemiaBax , Casp3 , Fas , Tlr4
Endotoxin HyporesponsivenessTlr4
Enterocolitis, NecrotizingTlr4
Erectile DysfunctionBax , Casp3
esophageal cancerTp53
Esophageal NeoplasmsBax , Casp8 , Fas , Tp53
Esophageal Squamous Cell CarcinomaTp53
Exfoliation SyndromeTlr4
Eye DiseasesTlr4
Eye Infections, FungalTlr4
Familial Mediterranean FeverTlr4
Fatty LiverTlr4
Fetal Growth RetardationBax , Casp3 , Fas
Fungal KeratitisTlr4
Gallbladder NeoplasmsTp53
Gastrointestinal HemorrhageBax
Giant Cell ArteritisTlr4
GlaucomaBax , Fas
Glaucoma, Primary Open AngleTlr4 , Tp53
GliomaFas , Tp53
GlomerulonephritisBax , Fas , Tlr4
Glomerulonephritis, MembranoproliferativeTlr4
Graft vs Host DiseaseFas , Tp53
Graves DiseaseFas , Tp53
Hashimoto DiseaseFas
Head and Neck NeoplasmsTp53
Hearing LossTlr4
Heart DiseasesBax
Heart FailureBax , Fas , Tp53
Heart Valve DiseasesCasp3
Hematologic DiseasesFas
Hepatitis, ChronicCasp3
Hepatorenal SyndromeTlr4
Heroin DependenceFas
HIV InfectionsBax , Fas
Huntington DiseaseBax , Casp3 , Casp8 , Fas
HypertensionBax , Casp3 , Tlr4 , Tp53
Hypertension, PulmonaryTlr4 , Tp53
Hypoxia-Ischemia, BrainBax , Casp3 , Fas
Idiopathic Pulmonary FibrosisFas
Immunologic Deficiency SyndromesCasp8
Infarction, Middle Cerebral ArteryBax , Casp3
Infectious MononucleosisFas
Infertility, FemaleTp53
Infertility, MaleBax , Fas , Tp53
Inflammatory Bowel Disease 11Casp3
Insulin ResistanceTlr4
Intermittent ClaudicationBax , Casp3
Intestinal DiseasesBax , Casp3
Intestinal NeoplasmsBax
IschemiaBax , Tp53
Ischemic Attack, TransientBax , Casp3 , Fas
Kashin-Beck DiseaseBax , Fas
Keratitis, HerpeticTlr4
Kidney Failure, ChronicTlr4
Kidney Reperfusion InjuryBax , Casp3 , Tlr4
Leishmaniasis, CutaneousTlr4
Leukemia, Lymphocytic, Chronic, B-CellFas , Tp53
Leukemia, Megakaryoblastic, AcuteTp53
Leukemia, Megakaryoblastic, of Down SyndromeTp53
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveFas
Leukemia, Myeloid, AcuteFas , Tp53
Leukemia-Lymphoma, Adult T-CellFas , Tp53
Leukodystrophy, Hypomyelinating, with Hypodontia and Hypogonadotropic HypogonadismTp53
Leukoplakia, OralTp53
Li-Fraumeni SyndromeTp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
Lichen Planus, OralTlr4 , Tp53
Lip NeoplasmsTp53
Lipoyltransferase 1 DeficiencyTp53
liver cancerCasp8 , Tp53
Liver Cirrhosis, ExperimentalFas , Tlr4
Liver Diseases, ParasiticTp53
Liver Failure, AcuteFas , Tlr4
Liver NeoplasmsCasp8 , Tp53
Liver Neoplasms, ExperimentalTp53
Liver Reperfusion InjuryBax , Casp8 , Fas , Tlr4
Low Tension GlaucomaTlr4 , Tp53
Lung DiseasesTlr4
Lung InjuryTlr4
Lung NeoplasmsCasp8 , Fas , Tlr4 , Tp53
Lung Reperfusion InjuryBax , Casp3 , Tlr4
Lupus Erythematosus, SystemicFas , Tlr4
Lymphatic MetastasisFas , Tlr4 , Tp53
Lymphoma, B-Cell, Marginal ZoneTp53
Lymphoma, Extranodal NK-T-CellFas
Lymphoma, Large B-Cell, DiffuseFas
Lymphoma, Non-HodgkinTp53
Lymphoma, T-CellTp53
Lymphoma, T-Cell, CutaneousBax , Fas , Tp53
Lymphoproliferative DisordersFas
Macular DegenerationBax , Fas , Tlr4
Macular Degeneration, Age-Related, 10Tlr4
Malaria, FalciparumFas
Mammary Neoplasms, ExperimentalBax , Casp3 , Casp8 , Fas , Tp53
MelanomaCasp8 , Fas , Tlr4 , Tp53
Melanoma, Cutaneous Malignant, Susceptibility To, 1Tp53
Meningitis, Escherichia ColiTlr4
Meningitis, MeningococcalTlr4
Meningitis, PneumococcalTlr4
Meningitis, ViralTlr4
Mesothelioma, MalignantTp53
Microsatellite InstabilityBax
Mixed Connective Tissue DiseaseFas
Morphine DependenceBax
Mouth NeoplasmsTp53
Moyamoya DiseaseFas
Mucocutaneous Lymph Node SyndromeTlr4
Multiple MyelomaTp53
Multiple SclerosisFas , Tlr4
Multiple Sclerosis, Relapsing-RemittingFas
Multiple System AtrophyFas
Multisystemic Smooth Muscle Dysfunction SyndromeFas
Muscular Dystrophy, Limb-Girdle, Type 2ATp53
Myasthenia GravisFas
Mycoplasma InfectionsCasp3
Myelodysplastic SyndromesFas , Tp53
Myocardial InfarctionBax , Casp3 , Tlr4 , Tp53
Myocardial IschemiaBax
Myocardial Reperfusion InjuryBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Myositis, Inclusion BodyFas
Nasal PolypsFas , Tlr4
Nasopharyngeal CarcinomaTp53
Nasopharyngeal NeoplasmsTp53
Neoplasm InvasivenessTlr4
Neoplasm MetastasisBax , Casp3 , Fas , Tlr4 , Tp53
Neoplasms, ExperimentalTp53
Neoplastic Syndromes, HereditaryTp53
Nephritis, InterstitialBax
Nephrosis, Puromycin AminonucleosideFas
Nerve DegenerationBax , Casp3
Nerve Sheath NeoplasmsTp53
Nervous System DiseasesCasp3 , Tp53
Neuritis, Autoimmune, ExperimentalTlr4
Neuropathy, PainfulTlr4
Neurotoxicity SyndromesCasp3
Non-alcoholic Fatty Liver DiseaseFas , Tlr4
Nose NeoplasmsTp53
Ocular HypertensionFas
Odontogenic MyxomaTp53
Onchocerciasis, OcularTlr4
Optic Atrophy, Hereditary, LeberTp53
Optic Nerve InjuriesBax , Tlr4
Oral Submucous FibrosisTp53
Oropharyngeal NeoplasmsTp53
Osteoarthritis, KneeBax
Osteoarthritis, Temporomandibular JointFas
Otitis MediaTlr4
Otitis Media with EffusionTlr4
Otitis Media, SuppurativeTlr4
ovarian cancerTp53
Ovarian NeoplasmsFas , Tlr4 , Tp53
ovarian serous cystadenocarcinomaTp53
ovary epithelial cancer Tp53
Oxygen-Induced RetinopathyFas
Pancreatic AdenocarcinomaTp53
pancreatic carcinoma Tp53
Pancreatic NeoplasmsCasp8 , Tp53
PancreatitisCasp3 , Tlr4
Pancreatitis, Acute NecrotizingCasp3 , Tlr4
papillary renal cell carcinoma Tp53
Papillary Renal Cell Carcinoma, SporadicTp53
Papilloma, Choroid PlexusTp53
Papillomavirus InfectionsCasp8
Paranasal Sinus NeoplasmsTp53
Parkinson DiseaseFas
Penile NeoplasmsTp53
Peripheral Vascular DiseasesFas
Phyllodes TumorTp53
Plaque, AtheroscleroticTlr4
Pneumonia, BacterialTlr4
Polycystic Ovary SyndromeBax
Pre-EclampsiaFas , Tlr4
Precancerous ConditionsTp53
Precursor B-Cell Lymphoblastic Leukemia-LymphomaTp53
Precursor Cell Lymphoblastic Leukemia-LymphomaCasp8 , Fas , Tp53
Precursor T-Cell Lymphoblastic Leukemia-LymphomaBax
Pregnancy Complications, CardiovascularFas
Primary MyelofibrosisTp53
prostate cancerTp53
Prostatic NeoplasmsBax , Casp3 , Fas , Tlr4 , Tp53
Pseudomonas Aeruginosa KeratitisTlr4
PsoriasisTlr4 , Tp53
Pulmonary AspergillosisTlr4
Pulmonary Disease, Chronic ObstructiveTlr4 , Tp53
Pulmonary EdemaTlr4
Pulmonary EmphysemaTlr4
Pulmonary FibrosisTlr4
Purpura, Thrombocytopenic, IdiopathicFas
Radiation Injuries, ExperimentalFas
Renal FibrosisTlr4
Renal InsufficiencyTlr4
Reperfusion InjuryBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Respiratory HypersensitivityTlr4
Respiratory SoundsTlr4
Respiratory Syncytial Virus InfectionsTlr4
Retina Reperfusion InjuryBax , Tlr4
Retinal DegenerationBax
Retinal DetachmentCasp3 , Fas
Retinal DiseasesCasp3
Rhinitis, AllergicTlr4
Rhinitis, Allergic, SeasonalTlr4
Salivary Gland DiseasesCasp3
Sarcoma Family Syndrome of Li and FraumeniTp53
Sarcoma, KaposiTp53
Sciatic NeuropathyTlr4
Scleroderma, LimitedFas
SepsisCasp3 , Casp8 , Fas , Tlr4
Sezary SyndromeTp53
Sjogren's SyndromeFas
Skin NeoplasmsCasp8 , Tp53
Small Cell Lung CarcinomaTp53
Spinal Cord CompressionFas
Spinal Cord InjuriesCasp3 , Fas , Tp53
Spinal Cord Reperfusion InjuryTlr4
Spondylitis, AnkylosingTlr4
Squamous Cell Carcinoma of the LungTp53
Squamous Cell Carcinoma of the TongueTp53
Status EpilepticusBax , Casp3 , Casp8
Stomach NeoplasmsCasp8 , Tp53
Stress Disorders, Post-TraumaticBax
StrokeCasp3 , Tlr4
Subarachnoid HemorrhageCasp3 , Tlr4
Taste DisordersFas
Testicular InjuryFas
Thymus NeoplasmsTp53
Thyroid Carcinoma, AnaplasticTp53
Thyroid NeoplasmsTp53
Tongue NeoplasmsTp53
Transplant RejectionTlr4
Trigeminal Nerve InjuriesTp53
Tuberculosis, PleuralTlr4
Tuberculosis, PulmonaryTlr4
Tumor Predisposition SyndromeTp53
Urinary Bladder NeoplasmsBax , Casp3 , Fas , Tlr4 , Tp53
Urinary Tract InfectionsTlr4
Urogenital NeoplasmsTp53
Urologic NeoplasmsTp53
uterine carcinosarcomaTp53
Uterine Cervical NeoplasmsBax , Casp3 , Casp8 , Tp53
Uterine NeoplasmsTp53
Uveitis, AnteriorTlr4
Uveitis, Autoimmune, ExperimentalFas , Tlr4
Ventricular Dysfunction, LeftFas , Tlr4
Vulvar Lichen SclerosusTp53
Vulvar NeoplasmsTp53
Wallerian DegenerationTlr4
Wilms TumorTp53
Xeroderma PigmentosumTp53
Pathway Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway
Pathway TermsGene Symbols
allograft rejection pathwayFas
altered p53 signaling pathwayTp53
Alzheimer disease pathwayCasp3 , Casp8 , Fas
amyotrophic lateral sclerosis disease pathwayBax , Casp3 , Tp53
apoptotic cell death pathwayBax , Casp3 , Casp8 , Fas , Tp53
autoimmune thyroid disease pathwayFas
basal cell carcinoma pathwayTp53
bladder cancer pathwayTp53
cell cycle pathway, mitoticTp53
ceramide signaling pathwayBax , Casp8 , Tp53
chronic myeloid leukemia pathwayTp53
colorectal cancer pathwayBax , Casp3 , Tp53
cytokine mediated signaling pathwayFas
endometrial cancer pathwayTp53
Endoplasmic Reticulum-associated degradation pathwayBax
Entamoeba histolyca infection pathwayCasp3 , Tlr4
extrinsic apoptotic pathwayCasp3 , Casp8 , Fas
FasL mediated signaling pathwayCasp3 , Casp8 , Fas
glioma pathwayTp53
graft-versus-host disease pathwayFas
hepatitis C virus infection pathwayTp53
Huntington disease pathwayBax , Casp3 , Casp8 , Tp53
influenza A virus infection pathwayFas , Tlr4
intrinsic apoptotic pathwayBax , Casp3 , Fas
Leishmania infection pathwayTlr4
measles infection pathwayFas , Tlr4 , Tp53
melanoma pathwayTp53
mitogen activated protein kinase signaling pathwayCasp3 , Fas , Tp53
Mycobacterium tuberculosis infection pathwayBax , Casp3 , Casp8 , Tlr4
myocarditis pathwayCasp3 , Casp8
neurotrophic factor signaling pathwayBax , Tp53
NOD-like receptor signaling pathwayCasp8
non-small cell lung cancer pathwayTp53
p53 signaling pathwayBax , Casp3 , Casp8 , Fas , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayTp53
Parkinson disease pathwayCasp3
phagocytosis pathwayTlr4
Plasmodium infection pathwayTlr4
prion diseases pathwayBax
prostate cancer pathwayTp53
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8
rheumatoid arthritis disease pathwayTlr4
small cell lung cancer pathwayTp53
syndecan signaling pathwayBax , Casp3
thyroid cancer pathwayTp53
titanium dioxide nanoparticle response pathwayBax , Casp3 , Casp8 , Fas , Tlr4 , Tp53
Toll-like receptor signaling pathwayCasp8 , Tlr4
Toxoplasma gondii infection pathwayCasp3 , Casp8 , Tlr4
Trail mediated signaling pathwayCasp3 , Casp8
Trypanosoma brucei infection pathwayFas
Trypanosoma cruzi infection pathwayCasp8 , Fas , Tlr4
tumor necrosis factor mediated signaling pathwayCasp8
type 1 diabetes mellitus pathwayFas
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayTp53
Phenotype Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway

References Associated with the titanium dioxide nanoparticle response pathway:

Ontology Path Diagram:

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