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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3decreases expressionEXP 6480464CTDEndosulfan results in decreased expression of CASP3 mRNAPMID:29391264
Casp3multiple interactionsEXP 6480464CTDEndosulfan results in increased cleavage of and results in increased activity of CASP3 protein; PRKCD affects the reaction [Endosulfan results in increased cleavage of and results in increased activity of CASP3 protein]PMID:30796443
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDEndosulfan results in increased activity of CASP3 proteinPMID:17189834 PMID:20361990 PMID:26615145 PMID:26714676 PMID:28161397 PMID:29705383
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDEndosulfan results in increased expression of CASP3 proteinPMID:36513242
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Endosulfan results in increased activity of CASP3 protein]; MIR22 mRNA affects the reaction [Endosulfan results in increased activity of CASP3 protein]; MIR22 mRNA affects the reaction [Endosulfan results in increased expression of CASP3 mRNA]PMID:20361990 PMID:28161397
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