Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 mRNA]; [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased degradation of CASP3 protein; Wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP3 protein]
[2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CASP3 protein
2,4,5,2',4',5'-hexachlorobiphenyl affects the reaction [dibenzo(a,l)pyrene results in increased cleavage of CASP3 protein]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]; 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 mRNA]; 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 protein]; Okadaic Acid inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]]
