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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:15600
Term: (+)-catechin
Definition: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.
Chemical ID: MESH:D002392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDCatechin analog inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 mRNA]; Catechin analog inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 protein]PMID:34027802
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDCatechin analog results in increased activity of CASP3 protein; Catechin results in increased activity of CASP3 proteinPMID:16413414 PMID:20206613
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDCatechin results in increased expression of CASP3 mRNA; Catechin results in increased expression of CASP3 proteinPMID:23706674
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDCatechin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Catechin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]PMID:16753784 PMID:20883750
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDCatechin inhibits the reaction [catechol results in increased activity of CASP3 protein]PMID:20347921
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