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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:36386
Term: dichloroacetic acid
Definition: An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis.
Chemical ID: MESH:D003999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDDichloroacetic Acid results in increased expression of CASP3 proteinPMID:22705712
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDDichloroacetic Acid affects the expression of and results in increased cleavage of CASP3 proteinPMID:25630799
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