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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3decreases expressionEXP 6480464CTDCaffeine results in decreased expression of CASP3 protein modified formPMID:18283038
Casp3increases activityEXP 6480464CTDCaffeine results in increased activity of CASP3 proteinPMID:12395097
Casp3increases cleavageEXP 6480464CTDCaffeine results in increased cleavage of CASP3 proteinPMID:21081844
Casp3increases expressionEXP 6480464CTDCaffeine results in increased expression of CASP3 mRNAPMID:19815060 PMID:31874197 PMID:35917217
Casp3multiple interactionsEXP 6480464CTD[Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 proteinPMID:15537744
Casp3affects cleavageISOCASP3 (Homo sapiens)6480464CTDCaffeine affects the cleavage of CASP3 proteinPMID:19242509
Casp3decreases phosphorylationISOCASP3 (Homo sapiens)6480464CTDCaffeine results in decreased phosphorylation of CASP3 proteinPMID:35688186
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDCaffeine results in increased activity of CASP3 proteinPMID:12378022 PMID:21229324
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDCaffeine results in increased cleavage of CASP3 proteinPMID:12907610
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein; Caffeine inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; Caffeine inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Caffeine promotes the reaction [[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP3 protein; NOTCH1 protein mutant form inhibits the reaction [Caffeine promotes the reaction [[Doxorubicin co-treated with Nocodazole co-treated with Hydroxyurea] results in increased cleavage of CASP3 protein]]PMID:16522534 PMID:16777994 PMID:18201823 PMID:19490937 PMID:31597699
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