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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:47781
Term: desipramine
Definition: A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Chemical ID: MESH:D003891
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDDesipramine results in increased activity of CASP3 proteinPMID:20549303
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDDesipramine results in increased activity of CASP3 proteinPMID:18986328
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [Desipramine results in increased cleavage of and results in increased activity of CASP3 protein]; Desipramine results in increased cleavage of and results in increased activity of CASP3 proteinPMID:18606486
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