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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of CASP3 mRNAPMID:27288928 PMID:33354967
Casp3multiple interactionsEXP 6480464CTD[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]PMID:27288928
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of CASP3 proteinPMID:22743290
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDAflatoxin B1 results in increased activity of CASP3 proteinPMID:35304092
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDAflatoxin B1 results in increased cleavage of CASP3 proteinPMID:33421461 PMID:34396909
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDAflatoxin B1 results in increased cleavage of CASP3 proteinPMID:22743290
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDAflatoxin B1 results in increased expression of CASP3 mRNA; Aflatoxin B1 results in increased expression of CASP3 proteinPMID:19770486 PMID:25445755 PMID:28789997 PMID:30126036
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of CASP3 mRNAPMID:27017951 PMID:30668976
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDdeoxynivalenol promotes the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; PRKN protein affects the reaction [Aflatoxin B1 results in increased activity of CASP3 protein]PMID:25445755 PMID:35304092
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Zearalenone co-treated with Aflatoxin B1] promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]; Aflatoxin B1 promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]; CYP2A13 protein promotes the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; gluconic acid promotes the reaction [Zinc Sulfate inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]]; Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Zinc Sulfate inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]PMID:22743290 PMID:27017951 PMID:30668976
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