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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:2781
Term: apocynin
Definition: An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Chemical ID: MESH:C056165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDacetovanillone analog inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of CASP3 protein]PMID:22497828 PMID:24291008 PMID:26522475 PMID:29859868
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDacetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]PMID:22147442 PMID:30366073
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [perfluorooctane sulfonic acid results in increased cleavage of CASP3 mRNA]PMID:20153346 PMID:36988283
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