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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:27882
Term: (S)-colchicine
Definition: A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.
Chemical ID: MESH:D003078
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDColchicine results in increased activity of CASP3 proteinPMID:12941380 PMID:15005753 PMID:16478524 PMID:20300959
Casp3increases cleavageEXP 6480464CTDColchicine results in increased cleavage of CASP3 proteinPMID:20624997
Casp3increases expressionEXP 6480464CTDColchicine results in increased expression of CASP3 mRNAPMID:18255150 PMID:19815060
Casp3multiple interactionsEXP 6480464CTDalsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; alvocidib inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; Lithium inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; SB 216763 inhibits the reaction [Colchicine results in increased activity of CASP3 protein]PMID:12941380 PMID:15005753 PMID:20300959
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDColchicine results in increased activity of CASP3 proteinPMID:22342440 PMID:33617922
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDColchicine results in increased cleavage of CASP3 proteinPMID:33684465
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDColchicine results in increased expression of CASP3 proteinPMID:33617922
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDdihydroactinidiolide inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; dihydroactinidiolide inhibits the reaction [Colchicine results in increased expression of CASP3 protein]PMID:33617922
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