GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | multiple interactions | EXP | | 6480464 | CTD | andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]] | PMID:20946909 | Casp3 | increases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | andrographolide results in increased activity of CASP3 protein | PMID:19097688 | Casp3 | increases cleavage | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | andrographolide results in increased cleavage of CASP3 protein | PMID:35917943 | Casp3 | increases expression | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | andrographolide results in increased expression of CASP3 mRNA | PMID:24563380 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein] | PMID:31706003 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | [andrographolide co-treated with Cisplatin] results in increased expression of CASP3 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein] | PMID:19097688 PMID:24563380 | | ||||||||||||||||||||||
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