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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275 Species: Rattus norvegicus RGD Object: Gene Symbol: Casp3 Name: caspase 3

Acc ID: CHEBI:10110 Term: zidovudine Definition: A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase. CasRN: 30516-87-1 Chemical ID: MESH:D015215

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731002	6480464	CTD	Drugs, Chinese Herbal promotes the reaction [Zidovudine results in increased expression of CASP3 mRNA]	PMID:17696246
increases activity	ISO	RGD:731002	6480464	CTD	Zidovudine results in increased activity of CASP3 protein	PMID:16601281
increases expression	ISO	RGD:731002	6480464	CTD	Zidovudine results in increased expression of CASP3 mRNA	PMID:17696246
multiple interactions	ISO	RGD:10289	6480464	CTD	2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine inhibits the reaction [Zidovudine results in increased expression of CASP3 protein] tauropyrone inhibits the reaction [Zidovudine results in increased expression of CASP3 protein] glutapyrone inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]	PMID:18801031
increases activity	ISO	RGD:10289	6480464	CTD	Zidovudine results in increased activity of CASP3 protein	PMID:17943461
increases expression	ISO	RGD:10289	6480464	CTD	Zidovudine results in increased expression of CASP3 protein	PMID:18801031