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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:2666
Term: amitriptyline
Definition: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Chemical ID: MESH:D000639
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDAmitriptyline results in increased activity of CASP3 proteinPMID:16717317
Casp3increases expressionEXP 6480464CTDAmitriptyline results in increased expression of CASP3 mRNAPMID:19815060
Casp3multiple interactionsEXP 6480464CTDAmitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]PMID:19135049
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