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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:34247
Term: 2,6-di-tert-butyl-4-methylphenol
Definition: A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.
Chemical ID: MESH:D002084
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDButylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased cleavage of and results in increased activity of CASP3 protein]; Butylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]PMID:10783138 PMID:27588890
Casp3decreases activityISOCASP3 (Homo sapiens)6480464CTDButylated Hydroxytoluene results in decreased activity of CASP3 proteinPMID:14981915
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein; zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone inhibits the reaction [[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein]PMID:16272459
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased activity of CASP3 proteinPMID:14981915
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