Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDChlorpyrifos results in increased activity of CASP3 proteinPMID:22714038 PMID:27941166 PMID:28373059 PMID:29859868 PMID:31823260
Casp3increases cleavageEXP 6480464CTDChlorpyrifos results in increased cleavage of CASP3 proteinPMID:29859868
Casp3increases expressionEXP 6480464CTDChlorpyrifos results in increased expression of CASP3 mRNA; Chlorpyrifos results in increased expression of CASP3 proteinPMID:31823260 PMID:32096903 PMID:33586219 PMID:33908150 PMID:34060014 PMID:35439518
Casp3multiple interactionsEXP 6480464CTD[Hesperidin co-treated with Chlorpyrifos] results in increased expression of CASP3 mRNA; acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 mRNA]; Chlorpyrifos promotes the reaction [iprodione results in increased expression of CASP3 protein]; Eugenol inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein]; gingerol inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]; iprodione promotes the reaction [Chlorpyrifos results in increased expression of CASP3 protein]; Plant Extracts inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 mRNA]; STAT1 protein affects the reaction [Chlorpyrifos results in increased activity of CASP3 protein]PMID:22714038 PMID:28373059 PMID:29859868 PMID:31823260 PMID:32096903 PMID:33586219 PMID:33908150 PMID:34060014 PMID:35439518
Casp3affects cleavageISOCASP3 (Homo sapiens)6480464CTDChlorpyrifos affects the cleavage of CASP3 proteinPMID:26070385
Casp3affects expressionISOCasp3 (Mus musculus)6480464CTDChlorpyrifos affects the expression of CASP3 proteinPMID:33349080
Casp3decreases expressionISOCasp3 (Mus musculus)6480464CTDChlorpyrifos results in decreased expression of CASP3 mRNAPMID:29156651 PMID:30378422
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDChlorpyrifos results in increased activity of CASP3 proteinPMID:26210949
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDChlorpyrifos results in increased activity of CASP3 proteinPMID:18996166 PMID:26198043 PMID:29859868
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDChlorpyrifos results in increased cleavage of CASP3 proteinPMID:30378422 PMID:34289071 PMID:36811218
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDChlorpyrifos results in increased cleavage of CASP3 proteinPMID:24793810 PMID:28549829 PMID:36058312
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDChlorpyrifos results in increased expression of CASP3 mRNA; Chlorpyrifos results in increased expression of CASP3 proteinPMID:29407956 PMID:30378422 PMID:32149475
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of CASP3 protein; Chlorpyrifos results in increased expression of CASP3 protein modified formPMID:23416140 PMID:26070385 PMID:26435000 PMID:31136966
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chlorpyrifos results in increased activity of and results in increased cleavage of CASP3 protein]; [cypermethrin co-treated with Chlorpyrifos co-treated with profenofos] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased activity of and results in increased cleavage of CASP3 protein]; BBC3 gene mutant form inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Chlorpyrifos results in increased activity of and results in increased cleavage of CASP3 protein]; Chlorpyrifos results in increased activity of and results in increased cleavage of CASP3 protein; Chlorpyrifos results in increased expression of and results in increased cleavage of CASP3 protein; DDIT3 protein affects the reaction [Chlorpyrifos results in increased activity of and results in increased cleavage of CASP3 protein]; ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]PMID:21987380 PMID:32798940 PMID:34289071 PMID:36252918 PMID:36811218
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of CASP3 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of CASP3 protein; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of CASP3 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of CASP3 protein; [Chlorpyrifos affects the localization of CYCS protein] which results in increased activity of CASP3 protein; MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein]; PRKN protein inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]; PRKN protein inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein modified form]; Rosiglitazone promotes the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein modified form]PMID:23416140 PMID:24793810 PMID:26070385 PMID:26435000 PMID:32800223
Go Back to source page   Continue to Ontology report