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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:48517
Term: 7H-xanthine
Definition: An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
Chemical ID: MESH:D019820
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTD3,4-dihydroxyphenylethanol inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein]; [Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein; [Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]; Quercetin inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein]PMID:19135123 PMID:26374991
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[Xanthine co-treated with XDH protein] results in increased activity of CASP3 proteinPMID:19268487
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