Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTDcypermethrin results in increased expression of CASP3 mRNA; cypermethrin results in increased expression of CASP3 proteinPMID:25370934 PMID:35876585
Casp3multiple interactionsEXP 6480464CTD[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] affects the expression of CASP3 mRNA; cypermethrin results in increased cleavage of and results in increased activity of CASP3 protein; Quercetin inhibits the reaction [cypermethrin results in increased expression of CASP3 mRNA]; Quercetin inhibits the reaction [cypermethrin results in increased expression of CASP3 protein]PMID:22048644 PMID:34896426 PMID:35876585
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDcypermethrin results in increased activity of CASP3 proteinPMID:29945211
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDcypermethrin results in increased expression of CASP3 mRNAPMID:34714723
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDcypermethrin results in increased expression of CASP3 mRNAPMID:27704156 PMID:29945211 PMID:32028016
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[cypermethrin co-treated with Chlorpyrifos co-treated with profenofos] results in increased cleavage of CASP3 proteinPMID:21987380
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [cypermethrin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of CASP3 mRNA]; cypermethrin inhibits the reaction [Docosahexaenoic Acids results in increased cleavage of and results in increased activity of CASP3 protein]PMID:11341974 PMID:29945211
Go Back to source page   Continue to Ontology report