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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3affects expressionEXP 6480464CTDbisphenol A affects the expression of CASP3 mRNAPMID:25181051
Casp3decreases cleavageEXP 6480464CTDbisphenol A results in decreased cleavage of CASP3 proteinPMID:24884420 PMID:27296223
Casp3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CASP3 mRNA; bisphenol A results in decreased expression of CASP3 proteinPMID:24464975 PMID:38006930
Casp3increases activityEXP 6480464CTDbisphenol A results in increased activity of CASP3 proteinPMID:23788033 PMID:25454643 PMID:25461564 PMID:26877094 PMID:32153214
Casp3increases cleavageEXP 6480464CTDbisphenol A results in increased cleavage of CASP3 proteinPMID:23328667 PMID:25461909 PMID:25963729 PMID:30641872 PMID:33582411 PMID:35887390
Casp3increases expressionEXP 6480464CTDbisphenol A results in increased expression of CASP3; bisphenol A results in increased expression of CASP3 mRNA; bisphenol A results in increased expression of CASP3 protein; bisphenol A results in increased expression of CASP3 protein modified formPMID:16909604 PMID:17322771 PMID:23554804 PMID:24768697 PMID:25461564 PMID:25461909 PMID:27296223 PMID:27539358 PMID:27925325 PMID:35465754 PMID:35648353 PMID:35699857 PMID:35890622 PMID:38027817
Casp3multiple interactionsEXP 6480464CTD18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of CASP3]; [bisphenol A co-treated with 4-nonylphenol] results in increased expression of CASP3 mRNA; [Genistein co-treated with bisphenol A] results in decreased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; bisphenol A inhibits the reaction [4-nonylphenol results in increased expression of CASP3 protein modified form]; bisphenol A inhibits the reaction [Genistein results in increased cleavage of CASP3 protein]; bisphenol A results in increased expression of and results in increased cleavage of CASP3 protein; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Fluvastatin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]; Fulvestrant inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; Genistein inhibits the reaction [bisphenol A results in decreased cleavage of CASP3 protein]; Lycopene inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; NR4A1 protein inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]PMID:23788033 PMID:24884420 PMID:25454643 PMID:25461564 PMID:25963729 PMID:30228064 PMID:30641872 PMID:32153214 PMID:33582411 PMID:35465754 PMID:35567931 PMID:35699857
Casp3decreases activityISOCASP3 (Homo sapiens)6480464CTDbisphenol A results in decreased activity of CASP3 proteinPMID:21277958 PMID:23850738
Casp3decreases expressionISOCasp3 (Mus musculus)6480464CTDbisphenol A results in decreased expression of CASP3; bisphenol A results in decreased expression of CASP3 proteinPMID:24909818 PMID:25205691
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CASP3 mRNA; bisphenol A results in decreased expression of CASP3 proteinPMID:21277958 PMID:23850738 PMID:29275510 PMID:37567409 PMID:38006930
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDbisphenol A results in increased activity of CASP3 proteinPMID:16684133 PMID:18521933 PMID:29161229 PMID:31387175 PMID:33485121
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDbisphenol A results in increased activity of CASP3 proteinPMID:30036487 PMID:30841469 PMID:31278978 PMID:33039870 PMID:34664771
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDbisphenol A results in increased cleavage of CASP3 proteinPMID:24905940 PMID:32407858 PMID:33771661 PMID:35219798 PMID:36451259 PMID:36858637
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDbisphenol A results in increased cleavage of CASP3 proteinPMID:20214975 PMID:30953815
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDbisphenol A results in increased expression of CASP3 mRNA; bisphenol A results in increased expression of CASP3 proteinPMID:19193734 PMID:21932408 PMID:23900028 PMID:31387175 PMID:33485121 PMID:34186417 PMID:38021376
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDbisphenol A results in increased expression of CASP3 mRNA; bisphenol A results in increased expression of CASP3 proteinPMID:28951153 PMID:30036487 PMID:30841469 PMID:31400064 PMID:35439536
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [bisphenol A results in increased expression of and results in increased cleavage of CASP3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; [bisphenol A co-treated with Dietary Fats co-treated with Cholesterol co-treated with Cholic Acid] results in increased cleavage of CASP3 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CASP3 protein; [Palmitates co-treated with bisphenol A] results in increased cleavage of CASP3 protein; [Streptozocin co-treated with bisphenol A] results in increased expression of CASP3 mRNA; Acetylcysteine inhibits the reaction [[bisphenol A co-treated with Dietary Fats co-treated with Cholesterol co-treated with Cholic Acid] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; bisphenol A results in decreased expression of and results in decreased cleavage of CASP3 protein; bisphenol A results in increased expression of and results in decreased cleavage of CASP3 protein; bisphenol A results in increased expression of and results in increased cleavage of CASP3 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CASP3 mRNA]; Imatinib Mesylate inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; KN 62 inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; KN 93 inhibits the reaction [bisphenol A results in increased expression of and results in increased cleavage of CASP3 protein]; Oleic Acid inhibits the reaction [[Palmitates co-treated with bisphenol A] results in increased cleavage of CASP3 protein]; VDAC1 promotes the reaction [bisphenol A results in increased cleavage of CASP3 protein]; W 7 inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; W 7 inhibits the reaction [bisphenol A results in increased expression of and results in increased cleavage of CASP3 protein]PMID:24905940 PMID:26096086 PMID:26146954 PMID:29935216 PMID:32976987 PMID:33485121 PMID:34186417 PMID:35219798 PMID:35622622 PMID:35739755 PMID:36858637 PMID:38021376
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[bisphenol A co-treated with LEP protein] results in decreased activity of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased expression of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [bisphenol A results in decreased activity of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [bisphenol A results in decreased expression of CASP3 protein]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased activity of CASP3 protein]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [[LEP protein co-treated with bisphenol A] results in decreased expression of CASP3 protein]; [bisphenol A co-treated with LEP protein] results in decreased expression of CASP3 mRNA; [bisphenol A co-treated with LEP protein] results in decreased expression of CASP3 protein; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CASP3 mRNA; benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; bisphenol A promotes the reaction [LEP protein results in decreased activity of CASP3 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; LEP protein promotes the reaction [bisphenol A results in decreased activity of CASP3 protein]PMID:23850738 PMID:28628672 PMID:33039870 PMID:35439536
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