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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:30740
Term: ethylene glycol bis(2-aminoethyl)tetraacetic acid
Definition: A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.
Chemical ID: MESH:D004533
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]PMID:21544200
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Egtazic Acid inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein]PMID:26998625 PMID:29111403
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; Egtazic Acid promotes the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]PMID:19837105 PMID:20020783 PMID:21544200
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