RGD Reference Report - Attenuation of renoinflammatory cascade in experimental model of diabetic nephropathy by sesamol. - Rat Genome Database

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Attenuation of renoinflammatory cascade in experimental model of diabetic nephropathy by sesamol.

Authors: Kuhad, A  Sachdeva, AK  Chopra, K 
Citation: Kuhad A, etal., J Agric Food Chem. 2009 Jul 22;57(14):6123-8.
RGD ID: 2311440
Pubmed: PMID:19601660   (View Abstract at PubMed)
DOI: DOI:10.1021/jf901388g   (Journal Full-text)

Diabetes has become the most common single cause of end-stage renal disease (ESRD) in the United States and Europe. Approximately 30-40% of patients with type I and 15% with type II diabetes mellitus develop end ESRD. The study was designed to evaluate the impact of sesamol on renal function and renoinflammatory cascade in streptozotocin (STZ)-induced diabetes. STZ-induced diabetic rats were treated with sesamol (2, 4, and 8 mg/kg/day; po) or with vehicle from the fifth to eighth weeks. After 8 weeks, urine albumin excretion, urine output, serum creatinine, blood urea nitrogen, creatinine, and urea clearance were measured. Cytoplasmic and nuclear fractions of kidney were prepared for the quantification of oxidative-nitrosative stress (lipid peroxidation, superoxide dismutase, catalase, nonprotein thiols, total nitric oxide), tumor necrosis factor-alpha (TNF-alpha), tissue growth factor-1 beta (TGF-beta1), p65 subunit of NFkappabeta, and caspase-3. After 8 weeks of STZ injection, the rats produced significant alteration in renal function, increased oxidative-nitrosative stress, TNF-alpha, TGF-beta1, caspase-3 activity in cytoplasmic lysate, and active p65 subunit of NFkappabeta in nuclear lysate of kidney of diabetic rats. Interestingly, co-administration of sesamol significantly and dose-dependently prevented biochemical and molecular changes associated with diabetes. Moreover, diabetic rats treated with insulin-sesamol combination produced more pronounced effect on molecular parameters as compared to their respective groups. The data reveal that sesamol modulates the release of profibrotic cytokines, oxidative stress, ongoing chronic inflammation, and apoptosis and thus exerts a marked renoprotective effect.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies  ISOCasp3 (Rattus norvegicus)2311440; 2311440associated with Diabetes Mellitus more ...RGD 
Diabetic Nephropathies  IEP 2311440associated with Diabetes Mellitus more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp3  (caspase 3)

Genes (Mus musculus)
Casp3  (caspase 3)

Genes (Homo sapiens)
CASP3  (caspase 3)


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