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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:16990
Term: bilirubin IXalpha
Definition: A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
Chemical ID: MESH:D001663
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDBilirubin results in increased activity of CASP3 proteinPMID:28805483
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDBilirubin results in increased cleavage of CASP3 proteinPMID:23628428
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDBilirubin results in increased cleavage of CASP3 proteinPMID:27578021
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]; Bilirubin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; CYP2A5 protein inhibits the reaction [Bilirubin results in increased cleavage of CASP3 protein]PMID:20709802 PMID:23628428 PMID:27578021
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