GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | affects expression | EXP | | 6480464 | CTD | Cocaine affects the expression of CASP3 protein | PMID:16179556 | Casp3 | increases activity | EXP | | 6480464 | CTD | Cocaine results in increased activity of CASP3 protein | PMID:10604926 PMID:11392460 PMID:12639677 PMID:15365088 PMID:16638611 PMID:17084983 PMID:17635674 PMID:18974856 PMID:20600547 | Casp3 | increases cleavage | EXP | | 6480464 | CTD | Cocaine results in increased cleavage of CASP3 protein | PMID:14741756 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | [Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Cocaine results in increased cleavage of and results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Cocaine results in increased activity of CASP3 protein] | PMID:15365088 PMID:19183502 PMID:20600547 | Casp3 | affects expression | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Cocaine affects the expression of CASP3 mRNA | PMID:15681117 | Casp3 | increases cleavage | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Cocaine results in increased cleavage of CASP3 protein | PMID:29673861 PMID:30027653 PMID:30393195 | Casp3 | increases expression | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Cocaine results in increased expression of CASP3 protein | PMID:16686379 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | ADCYAP1 protein modified form affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; GPX1 affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; PRKCD protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [Cocaine results in increased cleavage of CASP3 protein]; TNF protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]] | PMID:29673861 PMID:30027653 PMID:30393195 | | ||||||||||||||||||||||
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