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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:7575
Term: nimodipine
Definition: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Chemical ID: MESH:D009553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDNimodipine inhibits the reaction [Sevoflurane results in increased expression of CASP3 protein modified form]PMID:33171207
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDNimodipine results in increased activity of CASP3 proteinPMID:22700542
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]PMID:30776390 PMID:33336902
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDPalmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP3 protein]PMID:22700542
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