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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:30314
Term: (R)-lipoic acid
Definition: The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.
Chemical ID: MESH:D008063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDThioctic Acid results in increased activity of CASP3 proteinPMID:15909127
Casp3increases expressionEXP 6480464CTDThioctic Acid results in increased expression of CASP3 protein modified formPMID:30605698
Casp3multiple interactionsEXP 6480464CTD[Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]PMID:17079870 PMID:19951573 PMID:21062633 PMID:29214690 PMID:30605698 PMID:32061141 PMID:34133789
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDThioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]PMID:21763304 PMID:23892647
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDThioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]PMID:27544635
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