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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:17846
Term: (S)-naringenin
Definition: The (S)-enantiomer of naringenin.
Chemical ID: MESH:C005273
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTDnaringenin results in increased expression of CASP3 mRNAPMID:34655599
Casp3multiple interactionsEXP 6480464CTDnaringenin inhibits the reaction [Glucose results in increased activity of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP3 mRNA]; naringenin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]PMID:23192364 PMID:34655599
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDnaringenin results in increased activity of CASP3 proteinPMID:19124070 PMID:22692793
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDnaringenin results in increased expression of CASP3 protein modified formPMID:27838343
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDnaringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]PMID:31254498
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