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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases degradationEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased degradation of CASP3 proteinPMID:19576244
Casp3increases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 protein modified formPMID:19576244 PMID:30029115
Casp3multiple interactionsEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased activity of and results in increased expression of CASP3 protein; 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 mRNA]; [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased degradation of CASP3 protein; MIR128-1 promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased activity of and results in increased expression of CASP3 protein]; ZLN005 inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased activity of and results in increased expression of CASP3 protein]PMID:19576244 PMID:36269211
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CASP3 proteinPMID:27060917
Casp3increases activityISOCasp3 (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased activity of CASP3 proteinPMID:23564643
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased cleavage of CASP3 proteinPMID:25462306 PMID:25797475
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 mRNAPMID:25462306
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 proteinPMID:19022289
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased cleavage of and results in increased activity of CASP3 protein; epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased cleavage of and results in increased activity of CASP3 protein]]; GCLM protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased cleavage of CASP3 protein]; troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased cleavage of and results in increased activity of CASP3 protein]PMID:25639565 PMID:25797475
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 mRNA]; 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CASP3 protein]PMID:19022289
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