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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:5062
Term: finasteride
Definition: An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia.
Chemical ID: MESH:D018120
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTDFinasteride results in increased expression of CASP3 mRNAPMID:24136188
Casp3multiple interactionsEXP 6480464CTDFinasteride inhibits the reaction [Testosterone results in decreased expression of CASP3 protein modified form]; Finasteride inhibits the reaction [Testosterone results in increased expression of CASP3 protein]PMID:25714330 PMID:27687055
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