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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:39501
Term: 2,2,2-tetramine
Definition: A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.
Chemical ID: MESH:D014266
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTDTrientine results in increased activity of CASP3 proteinPMID:22362149
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDTrientine results in increased activity of CASP3 proteinPMID:11369509 PMID:14513838
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDParaquat promotes the reaction [Trientine results in increased activity of CASP3 protein]; Trientine inhibits the reaction [APP protein results in increased activity of CASP3 protein]PMID:11369509 PMID:12963085
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