RGD Reference Report - Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NF¿B, oxidative stress, and apoptosis. - Rat Genome Database

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Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NF¿B, oxidative stress, and apoptosis.

Authors: Elsherbiny, Nehal M  Zaitone, Sawsan A  Mohammad, Hala M F  El-Sherbiny, Mohamed 
Citation: Elsherbiny NM, etal., Toxicol Mech Methods. 2018 Jul;28(6):467-473. doi: 10.1080/15376516.2018.1459995. Epub 2018 Apr 16.
RGD ID: 13792586
Pubmed: PMID:29606028   (View Abstract at PubMed)
DOI: DOI:10.1080/15376516.2018.1459995   (Journal Full-text)

The prevalence of diabetes mellitus (DM) is drastically increased worldwide. Diabetic nephropathy (DN) is a microvascular complication of DM and a common cause of end stage renal disease (ESRD). DN has been recently reported as the most common cause among ESRD patients. Shortage of a definitive cure for DN and the social and economic burden of this disease provide considerable impetus for development of new therapies. In the present study, we evaluated the effect of nifuroxazide, a potent inhibitor of Janus kinase/signal transducers and activators of transcription (JAK2/STAT3), on nuclear factor kappa B (NFκB), oxidative stress, and apoptosis in diabetic kidney. Following induction of diabetes by single dose of streptozotocin (50¿mg/kg), nifuroxazide was administrated to diabetic rats (25¿mg/kg/day, orally) for 8 weeks. Our results showed that nifuroxazide treatment, attenuated diabetes-induced damage in renal structure, ameliorated oxidative stress, triggered antioxidant defense, reduced NFκB nuclear translocation and cleaved caspase-3 expression and down regulated the activity of apoptotic enzymes (caspase-3/caspase-8/caspase-9) in diabetic kidney. In conclusion, nifuroxazide exhibited renoprotective effect in diabetic kidney via dampening NFκB activation, oxidative stress, and apoptosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies treatmentISOCasp3 (Rattus norvegicus)13792586; 13792586associated with Diabetes Mellitus and Experimental RGD 
Diabetic Nephropathies treatmentISOCasp8 (Rattus norvegicus)13792586; 13792586associated with Diabetes Mellitus and Experimental RGD 
Diabetic Nephropathies treatmentISOCasp9 (Rattus norvegicus)13792586; 13792586associated with Diabetes Mellitus and Experimental RGD 
Diabetic Nephropathies treatmentIEP 13792586; 13792586; 13792586associated with Diabetes Mellitus and Experimental RGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp3  (caspase 3)
Casp8  (caspase 8)
Casp9  (caspase 9)

Genes (Mus musculus)
Casp3  (caspase 3)
Casp8  (caspase 8)
Casp9  (caspase 9)

Genes (Homo sapiens)
CASP3  (caspase 3)
CASP8  (caspase 8)
CASP9  (caspase 9)


Additional Information