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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3affects expressionEXP 6480464CTDDichlorodiphenyl Dichloroethylene affects the expression of CASP3 proteinPMID:24576310
Casp3increases expressionEXP 6480464CTDDichlorodiphenyl Dichloroethylene results in increased expression of CASP3 mRNAPMID:19644561 PMID:20025943 PMID:21384494 PMID:24576310 PMID:25410718
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDDichlorodiphenyl Dichloroethylene results in increased activity of CASP3 proteinPMID:26563996 PMID:32721735
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene results in increased activity of CASP3 proteinPMID:19545618
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDATG7 protein affects the reaction [Dichlorodiphenyl Dichloroethylene results in increased activity of CASP3 protein]; BECN1 protein affects the reaction [Dichlorodiphenyl Dichloroethylene results in increased activity of CASP3 protein]; diazepinylbenzoic acid inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased activity of CASP3 protein]; ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased activity of CASP3 protein]; RXRA mRNA promotes the reaction [Dichlorodiphenyl Dichloroethylene results in increased activity of CASP3 protein]; RXRB mRNA promotes the reaction [Dichlorodiphenyl Dichloroethylene results in increased activity of CASP3 protein]PMID:26563996 PMID:32721735
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