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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:28262
Term: dimethyl sulfoxide
Definition: A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Chemical ID: MESH:D004121
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3decreases expressionEXP 6480464CTDDimethyl Sulfoxide results in decreased expression of CASP3 proteinPMID:36305173
Casp3multiple interactionsEXP 6480464CTD[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide co-treated with 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine] results in increased expression of CASP3 protein; [lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of CASP3 protein; Dimethyl Sulfoxide results in decreased cleavage of and results in decreased activity of CASP3 proteinPMID:12370186 PMID:37365769
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDDimethyl Sulfoxide results in increased cleavage of CASP3 proteinPMID:22535522
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