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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3affects expressionEXP 6480464CTDAtrazine affects the expression of CASP3PMID:21726175
Casp3increases activityEXP 6480464CTDAtrazine results in increased activity of CASP3 proteinPMID:21726175
Casp3increases expressionEXP 6480464CTDAtrazine results in increased expression of CASP3 mRNA; Atrazine results in increased expression of CASP3 proteinPMID:24863870 PMID:27102619 PMID:34090108 PMID:34663174 PMID:34994930 PMID:36282381
Casp3multiple interactionsEXP 6480464CTDCarnitine inhibits the reaction [Atrazine results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; kolaviron inhibits the reaction [Atrazine affects the expression of CASP3]; kolaviron inhibits the reaction [Atrazine results in increased activity of CASP3 protein]; Lycopene inhibits the reaction [Atrazine results in increased expression of CASP3 mRNA]PMID:21726175 PMID:24863870 PMID:27102619 PMID:36282381
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDAtrazine results in decreased expression of CASP3 mRNAPMID:22378314
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDAtrazine results in increased cleavage of CASP3 proteinPMID:25259610 PMID:33766575
Casp3increases expressionISOCasp3 (Mus musculus)6480464CTDAtrazine results in increased expression of CASP3 mRNA; Atrazine results in increased expression of CASP3 proteinPMID:33485040
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDAtrazine results in increased expression of CASP3 mRNAPMID:21333729
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTDMelatonin inhibits the reaction [Atrazine results in increased cleavage of CASP3 protein]PMID:25259610
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDkolaviron inhibits the reaction [Atrazine results in increased expression of CASP3 mRNA]PMID:21333729
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