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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:4775
Term: ellagic acid
Definition: An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.
Chemical ID: MESH:D004610
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDEllagic Acid inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of CASP3 protein]; Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased activity of CASP3 protein]PMID:28815802 PMID:29854611 PMID:34944019 PMID:35236242
Casp3decreases activityISOCASP3 (Homo sapiens)6480464CTDEllagic Acid results in decreased activity of CASP3 proteinPMID:22386815
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDEllagic Acid results in decreased expression of CASP3 mRNAPMID:12002526
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDEllagic Acid results in increased activity of CASP3 proteinPMID:23811531
Casp3increases expressionISOCASP3 (Homo sapiens)6480464CTDEllagic Acid results in increased expression of CASP3 mRNAPMID:12002526
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDEllagic Acid results in increased expression of and results in increased activity of CASP3 proteinPMID:23554011
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