Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:34690
Term: dichlorvos
Definition: An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.
Chemical ID: MESH:D004006
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3decreases expressionEXP 6480464CTDDichlorvos results in decreased expression of CASP3 mRNAPMID:19815060
Casp3increases activityEXP 6480464CTDDichlorvos results in increased activity of CASP3 proteinPMID:16973328 PMID:21784090 PMID:22817663
Casp3increases cleavageEXP 6480464CTDDichlorvos results in increased cleavage of CASP3 proteinPMID:24369695
Casp3increases expressionEXP 6480464CTDDichlorvos results in increased expression of CASP3 mRNAPMID:19815060
Casp3multiple interactionsEXP 6480464CTD[Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]; Dichlorvos results in increased cleavage of and results in increased activity of CASP3 protein; mitoquinone inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased cleavage of CASP3 protein]PMID:16973328 PMID:17850875 PMID:21784090 PMID:24369695
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDDichlorvos results in increased activity of CASP3 proteinPMID:17681413
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDbenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]PMID:17681413
Go Back to source page   Continue to Ontology report