GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | decreases expression | EXP | | 6480464 | CTD | arsenite results in decreased expression of CASP3 protein | PMID:18077580 | Casp3 | increases activity | EXP | | 6480464 | CTD | arsenite results in increased activity of CASP3 protein | PMID:18226606 | Casp3 | increases expression | EXP | | 6480464 | CTD | arsenite results in increased expression of CASP3 protein | PMID:29324385 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [arsenite results in decreased expression of CASP3 protein]; GDNF protein inhibits the reaction [arsenite results in increased activity of CASP3 protein]; Selenium inhibits the reaction [arsenite results in increased expression of CASP3 protein] | PMID:18077580 PMID:18226606 PMID:29324385 | Casp3 | increases activity | ISO | Casp3 (Mus musculus) | 6480464 | CTD | arsenite results in increased activity of CASP3 protein | PMID:17520061 PMID:18316066 PMID:35964836 | Casp3 | increases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | arsenite results in increased activity of CASP3 protein | PMID:22260869 PMID:35964836 | Casp3 | increases cleavage | ISO | Casp3 (Mus musculus) | 6480464 | CTD | arsenite results in increased cleavage of CASP3 protein | PMID:23396362 PMID:24457827 PMID:32443253 PMID:32980394 | Casp3 | increases cleavage | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | arsenite results in increased cleavage of CASP3 protein | PMID:17553788 PMID:24457827 | Casp3 | increases expression | ISO | Casp3 (Mus musculus) | 6480464 | CTD | arsenite results in increased expression of CASP3 mRNA | PMID:18929588 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [arsenite results in increased activity of CASP3 protein]; [sodium arsenite results in increased abundance of arsenite] which results in increased activity of CASP3 protein; acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [arsenite results in increased activity of CASP3 protein]; CALR protein affects the reaction [arsenite results in increased cleavage of CASP3 protein]; Cyclosporine inhibits the reaction [arsenite results in increased activity of CASP3 protein]; ERO1A protein affects the reaction [arsenite results in increased activity of CASP3 protein]; FBXW7 protein inhibits the reaction [arsenite results in increased cleavage of CASP3 protein]; FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite results in increased cleavage of CASP3 protein]]; MIR190A affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased cleavage of CASP3 protein]]; mitoquinone inhibits the reaction [NFE2L1 protein alternative form affects the reaction [arsenite results in increased cleavage of CASP3 protein]]; MYC protein inhibits the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite results in increased cleavage of CASP3 protein]]; MYC protein promotes the reaction [arsenite results in increased cleavage of CASP3 protein]; NFE2L1 alternative form affects the reaction [arsenite results in increased cleavage of CASP3 protein]; NFKB1 protein affects the reaction [arsenite results in increased cleavage of CASP3 protein]; PHLPP1 protein affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased cleavage of CASP3 protein]]; TRP53 protein inhibits the reaction [arsenite results in increased expression of CASP3 mRNA] | PMID:17520061 PMID:18929588 PMID:23396362 PMID:24457827 PMID:32443253 PMID:32980394 PMID:34453993 PMID:35964836 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [arsenite results in increased activity of CASP3 protein]; [arsenite results in decreased activity of PARP1 protein] which results in decreased cleavage of and results in decreased activity of CASP3 protein; [sodium arsenite results in increased abundance of arsenite] which results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [arsenite results in increased activity of CASP3 protein]; arsenite results in decreased cleavage of and results in decreased activity of CASP3 protein; arsenite results in increased cleavage of and results in increased activity of CASP3 protein; Cyclosporine inhibits the reaction [arsenite results in increased activity of CASP3 protein]; FBXW7 gene mutant form promotes the reaction [arsenite results in increased cleavage of CASP3 protein]; TP53 mutant form inhibits the reaction [arsenite results in increased activity of CASP3 protein] | PMID:20083129 PMID:22260869 PMID:22387748 PMID:24457827 PMID:34453993 PMID:35964836 | | ||||||||||||||||||||||
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